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46 Cards in this Set

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NO MOA
Ø NMDA
NO
+
low lambda
NO
-
no surg anesthesia, only adjuvant
HALOthane MOA
↑ GABA binding
↑ Cl influx
HALOthane +
non-irritating
mm relax
HALOthane -
high lambda
Ø analgesia
ASE-hypotn, tachyARR,
HEPATOX, malig hypRtherm
ENflurane MOA
↑GABA ↑Cl
ENflurane +
mod. analg
mm relax
ENflurane -
↓CO
↑seizures, C/I for pt with siezure d/o
ISOflurane MOA
↑GABA,
↑ Cl
ISOflurane +
mod sk mm relax
no effect on CO,↑ coronary BF, ↓ myocardial O2 demand
Prefered for neurosx
ISOflurane -
bad smell
bronchoirritates- coughing, spasms
DESflurane MOA
↑ GABA, ↑Cl
DESflurane +
lowest lambda--OP sx
DESflurane -
bronchospasm, have to use IV anesthetic for induction then use DESflurane for mantainence
SEVOflurane MOA
↑GABA ↑Cl
SEVOflurane +
low lamda
mm relax
Bronchodilator
pleasant odor
SEVOflurane -
possible kidney tox via Compound A
possibly ↑ siezures
ultra short BARB MOA
↑GABA, ↑Cl
prolong Cl
channel openign
ultra short BARB +
lipid sol
fast induct
ultra short BARB -
hyperalgesia-if alone-tachyC, diaphoresis
THIOPENTAL
methohexital, shorter t1/2
prolong Cl channel
opening
THIOPENTAL
methohexital, shorter t1/2
+
10-30s induct
↓ ICP,
used for induction and mantainence for short proced
Ketamine
anesth- ØNMDA
analg- opiod
Ketamine +
bronchodilator
No need for intubation as
respiration is spontaneous
Ketamine -
dysphoria(PCP related)
dilates cerebral vasc. ↑ICP
↑CO and BP, caution in cardiac pt, but useful for shock pt
-recovery- PCP dysphoric halluc, etc
admin BZ prior to ketamine can prevent these
Etomidate MOA
ultra short acting
NON barb hypnotique
Etomidate +
INDUCTION
miminal CV/ Resp, ideal for CV dz pt
Etomidate -
post-op N/V
not rec. for maintenance or in critcally ill pt
PROPOFOL MOA
Unknown
PROPOFOL +
rapid recovery
antiemetic-no postop N/V
PROPOFOL -
mild hypotn, mild neg INOtropic
ADJUNCTS TO GENERAL ANESTHESIA
--
BZs MOA
↑GABA, ↑Cl channel frequency
(end in lam or pam)
MIDazolam
short acting
DIAzepam
long acting
LORazepam
intermed acting
pre op anxiolytic
TRIazolam
PO only
pre op anxiolytic
amnesia
FLUMAZENIL
BZ blocker to reverse post-op sedation
OPIOIDS MOA, ending, SE
usu MU receptor
(usually end in TANIL, except morphine & demerol)
SE: resp. depr, ↑ ICP
SUFENtanil
MOST POTENT
used for pre, during, post-op analgesia
AFENtanil
shorter 1/2 life
used for pre, during, post-op analgesia
REMIFENtanil
t ½ = 10-15 min
analgesia during anesthesia
FENTanyl
80-100 x potent than morphine
NO HISTAMINE release
quick onset, short duration
MEPERidine
(Demerol)
shorter act than morphine
vagolytic- ↓ secretions
C/I w2 week/in 2wk s of MAOI-- serotonin syndrome
Morphine
histamine release
supresses cough reflex
↓cough-choke on ↑secretions
vasodilation – reflex TachC