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30 Cards in this Set

  • Front
  • Back
3 zones of adrenal cortex and their products
Glomerulosa (mineralocorticoids), fasciculata (glucocorticoid=GC), and reticularis (adrenal androgens)
Pneumonic for 3 zones of adrenal cortex
GFR
Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)
Glucocorticoids
Short acting glucocorticoids
Cortisone and hydrocortisone (equivalent to cortisol)
Intermediate acting glucocorticoids
Prednisone, methylprednisolone, prednisolone, and triamcinolone
Long acting glucocorticoids
Betamethasone and dexamethasone
Mineralocorticoids
Fludrocortisone and deoxycorticosterone
Some side effects of corticosteroids
Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis, stria, thinning of skin
Period of time of therapy after which GC therapy will need to be tapered
5-7 days, or several months after protracted use
Used for Cushing's syndrome ddx
Dexamethasone suppression test
Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Aminoglutethimide
Antifungal agent used for inhibition of all gonadal and adrenal steroids
Ketoconazole
Diuretics used to antagonize aldosterone receptors
Spironolactone, eplerenone
Common SE of spironolactone
Gynecomastia and hyperkalemia
glucocorticoid with greatest topical activity
dexamethasone
glucocorticoid with the greatest anti-inflamitory potency
dexamethasone
glucocorticoids used in asthma for their very sort half lives and ability to penetrate the mucosa
beclomethasone and budesonide
glucocorticoid and mineral corticoid insufficiency
Addison's disease
excess cortisol production
cushing disease or syndrome
what time of day is cortisol production higest and lowest?
highest- morning, lowest-midnight
glucocorticoid used in premature labor to hasten maturation of fetal lungs
betamethasone
glucocorticoids with mineral corticoid activity
cortisol, prednisone
MOA of aldosterone
inserts Na+ and K+ channels into luminal side of renal collecting tubules; increases water resorption with Na+ while K+ is excreated
action of ACTH
increases cortisol, aldosterone, and androgen production by: stimulating lipoprotein uptake into cortical cells (this increases the bio-availability of cholesterol in the cells of the adrenal cortex) increasing the transport of cholesterol into the mitochondria and activating its hydrolysis, stimulating the cholesterol side-chain cleavage enzyme CYP 450scc/cholesterol desmolase/20,22-desmolase (which is the rate-limiting step in the production of pregnenolone).
mineralcorticoid with anti-inflamitory activity
fludrocortisone
mineralcorticoid with long duration of action
fludrocortisone
drug used as an abortifant also used for cushing syndrome
Mifepristone
MOA of mifepristone
inhibitor of glucocorticoid and progesterone receptors
MOA of ketoconazole
inhibits CYP450 enzymes
drug which inhibits cortisol production, but not production of cortisol precursors (used to diagnose adrenal function)
metyrapone