Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/70

Click to flip

70 Cards in this Set

  • Front
  • Back
Heparin mechanism
activate antothrombin3
effective in vitro and vivo
Heparin administration
NOT ORAL- only IV or subq
emergencies
Heparin SE
transient thrombocytopenia
Heparin OD
give basic protamine to counteract acidic heparin
Warfarin mechanism
impair synth. of Vit. K dependent factors (2,7,9,10)...in vivo only
Warfarin admin.
ORAL- delayed onset

bound to plasma proteins (drug interxns)
Streptokinase mech.
convert -ogen--> plasmin

t1/2- 23min
NOT clot selective
antigenic
Atelapase mech.
-ogen--> plasmin

t1/2- 5min
clot selective
NOT antigenic
Asprin mech.
IRREV. acetylation COX1
Clopidogrel mech.
IRREV. inhibit ADP pathway on platelets
Ticlopidine mech.
IRREV. inhibit ADP pathway on platelets
Nitroglycerin mech., use
dilate venodilation

stable/ variant angina
Isosorbide dinitrate
dilate venodilation

stable/ variant angina
Propranlol mech., use
non-selective

dec. HR/ contractility
rebound tachy
stable angina, postMI
Metoprolol mech., use
selective

dec. HR/ contractility
rebound tachy
stable angina, postMI
Verapamil mech, use
Ca2+ blocker
vasodilation

variant angina
Diltiazem mech, use
Ca2+ blocker
vasodilation

variant angina
Nifedipine mech, use
Ca2+ blocker
vasodilation
REFLEX TACHY

variant angina
Qinidine mech
MODERATE Na blocker- dec. rate of rise phase 0, dec. conduction velocity

K block- inc. duration AP

selectivley suppress abnl automaticity
Quinidine therapy
both atria and ventricle
Quinidine Effects and SE
inc. HR
dec. BP

tinitus
blurred vision
EAD/ Toursade de Pt.
Lidocaine mech, admin
MINIMAL Na block- dec. rate of rise phase 0

selectivley suppress abnl automaticity

NO K BLOCK!

-IV only
Lidocaine therapeutics
ONLY ventricular

after acute MI
*treat digitalis induced ventric. arrythmia
Flecainide mech
POTENT Na block- dec. rate of rise phase 0, dec. conduction vel., dec. automaticity
Flecainide therapeutics
supress ventricle and atrial arryth.
Propranolol mech
block catech. (that cause arrythm.)

dec. automaticity (dec. HR)
dec. conduction thru AV node
Propranolol therapeutics
slow ventricular rate w/ atrial tachy (protect ventricle)

postMI
Metoprolol therapeutics
slow ventricular rate w/ atrial tachy (protect ventricle)

postMI
Amidarone mech.
Na block- slow conduction
K block- prolong reploz.
Amidarone therapeutics
atrial and ventricular arryth.
Amidarone SE
rare to get Toursade de Pt.

pulm. fibrosis
bradycardia
Sotalol mech.
K blocker- prolong vent. AP (interrupt rentry)

beta-blocker- dec. sympth.
Sotalol therapeutics
atrial and ventricle
Sotalol SE
Torsades de Pt. (like quinidine)
bradycardia
Verapamil mech. @ heart
dec. conduction at AV/ SA node (Ca dependent)

dec. HR (SA node)
dec. AV conduction

dec. contractility, BP
Verapamil therapeutics
atrial

NOT EFFECTIVE W/ VENTRICULAR TACHY
Digoxin mech in arryth
AV slowing by inc. vagal tone
Adenosine mech in arryth
activate adenosine-R at SA/ AV node

--> dec AV conduction, inc AV refractory period

for PARAOXYSMAL SUPRAVENT. TACHY
Albuterol mech.
inhaled B2 agonist

short acting bronchodilator (exercise induced)

no anti-inflamm
Salmeterol mech
inhaled B2 agonist

LONG acting bronchodilator (exercise induced)

slow onset- for prevention

no anti-inflamm
Ipratroprium mech
muscarinic-R antagonist (like atropine)

weak bronchodil.

long duration--> treat COPD

no antinflamm
Theophylline mech
adenosine- R block
inhibit phosphdiesterase

- inc. sensitivity of respir. center to CO2
- relax bronchiloe smooth m.
Theophylline admin.
ORAl- narrow saftey index

dose dependent toxicity
Fluticasone mech, use
synth. lipocortin- inhibt phospholipase A2

dec. inflamm and edema in respir. tract
--> for chronic asthma
Fluticasone SE
dysphonia
esophageal candidiasis
Cromolyn mech, uses
dec. Histamine release from mast cells (stablize mast cells)

prophylaxis (esp. kids b/c no toxicity)
Zafirlukast mech, use
block leukotriene recpetor

prophylaxis and chronic mild asthma ONLY

not acute

used in kids
Zileuton mech., use
inhibit lipoxygenase--> less leukotrienes

for asprin allergy and mild asthma
Zileuton SE
liver toxicity
Omeprazole mech
PPI--> irrev. bond w/ H/K ATPase

best for healing NSAID peptic ulcers

lipophilic prodrug
Omeprazole duration
can dec. acid sec. for 24hr

take 1 hr. b4 eating (dec. bioavail. w/ food)
Cimetidine mech
H2-R blocker

take b4 bed - inhibit both fasting and foos tsim. acid
Cimetidine SE
inhibit cycP450- interfere w/ metabolism of other drugs
Rantidine mech
H2-R blocker

take b4 bed - inhibit both fasting and foos tsim. acid
Antacids and use
Al(OH)3
Mg(OH)2
CaCO3

RAPID releif of heartburn, acid ingestion
Misoprostol mech
cytoprotective

inc. secretion of mucus
inhibit acid secretion
Misoprostol contraindic.
Do not use w/ pregnancy
Sucralfate mech
coat gastric mucosa
cytoprotective (PGE production)

reduce absorp. other drugs
Bismuth mech
selectively bind ulcer and coat
inc. secretion of mucus
Metoclopramide mech
MOTILITY

release Ach at myenteric plexus --> stimulate motility w/o inc acid

anti-emetic
Metoclopramide contrindic.
people w/ seizure or GI obstruction
Erythromycin mech.
MOTILITY

stimulate motilin- R (smooth m. contrxn)
Ondansteron mech.
block 5HT-R in stomach, CTZ, STN --> prevent n/v
Prochlorperazine mech
D2 blocker at CTZ

--> prevent n/v
Diphenhydramine mech
antihistamine
--> dec. n/v w/ motion sickness
Bisacodyl mech
LAXATIVE- stimulate colon
Docusate mech
LAXATIVE- stool softener (wetting/ dispersing)
Psyllium mech
LAXATIVE for chronic constipation

inc. intraluminal P
stimulate reflex peristalsis
MgOH mech
LAXATIVE- not absorbed, retain water in colon
PEG mech
LAXATIVE- inert, non-absorbale sugar

for complete colon cleaning