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9 Cards in this Set
- Front
- Back
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Which kind of patients are pre-disposed to serious fungal infections?
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- Immunocompromised (chemotherapy, immunomodulation, organ transplantation, AIDS)
- Broad-spectrum antibacterial use - Indwelling catheters |
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What causes challenges for treating fungal infections?
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- Eukaryotes - antifungals are relatively toxic
- Number of agents available is small - Many fungal infections occur in poorly vascularized areas (skin, nails, hair) - hampers adequate penetration and retention of therapeutic agents |
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How can mycoses be classified?
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- Systemic
- Superficial (mucous membranes) |
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What are the potential antifungal targets?
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- Membranes (ergosterol)
- Nucleic acids (limited) - Cell wall (1 drug class) |
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Which antifungals target systemic infections?
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- Amphotericin B
- Flucytosine - Fluconazole - Itraconazole - Voriconazole - Caspofungin |
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What locations are there infections of the mucous membranes by superficial mycoses?
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- Oropharyngeal
- Bladder - Vagina |
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Which antifungals target superficial infections?
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- Nystatin
- Fluconazole - Miconazole - Clotrimazole - Itraconazole - Natamycin |
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Which antifungal drug is administered to the eyes for eye infections (conjunctivitis)?
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Natamycin
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Which antifungals are used for dermatophytic infections (ringworm, athlete's foot, etc.)?
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TOPICAL:
- Miconazole - Clotrimazole - Tolnaftate - Terbinafine - Ciclopirox ORAL: - Terbinafine - Griseofulvin - Itraconazole |
