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151 Cards in this Set
- Front
- Back
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Etodolac
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COXII inhibitor; used after bypass sx
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Diclofenac
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COXI/II inihibitor; high concentration in synovial fluid --> good for RA
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Meclofenamate
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inhibits PG synthesis. short t1/2; enhances effect of oral anti coags, don’t use during pregnancy
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Piroxicam
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anti inflammatory; inihibition of neutrophil migration
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Indomethacin
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COX1/2 -I. analgesic, antipyretic, anti inflamm; good for Hodkins dz, treats PDA and acute gouty arthritis; SE = GI irritation/ulceration, renal tox
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Allopurinol
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competive inhibitor of xanthine oxidase's conversion of hypoxanthine --> uric acid
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Febuxostat
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direct inhibitor of xanthine oxidase
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Probenecid
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blocks urate absorption from URAT9 and secretion from OAT, but it blocks absorption more. So more uric acid stays in urine.
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Mecasermin
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IGF1 with BP33. Treats IGF1 def Laron dwarfism
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Pegvisomant
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GH antagonist
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Octreotide
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somatostatin (inhibits GH release). Treats acromegaly, carcinoid, WDHA syndrome.
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Conivaptan
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V1/V2 antagonist. Anti -vasopressin….
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hMG
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FSH activity; tx infertility
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Urofollitropin
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FSH activity. Either this or hMG is given to tx female hypogonadotrophism. It is then followed by hCG.
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hCG
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LH activity. Given to treat hypogonadotrophic men (and is then followed by hMG or urofollitropin). Can also treat crypotochidism.
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Gonadorelin
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GnRH. Treats infertility due to hypothalamic dysfunction in females. Pulsatile dosing.
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Leuprolide
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GnRH superagonist analog. Initially stimulates LH and FSH but induces desensitization and down reg of GnRH-R --> chem castration. Treats prostate CA, endometriosis, precocious pub, uterine fibroids. AE = osteoporosis, prostate CA flareup
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Nafarelin
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GnRH superagonist analog. Initially stimulates LH and FSH but induces desensitization and down reg of GnRH-R --> chem castration. Treats prostate CA, endometriosis, precocious pub, uterine fibroids. AE = osteoporosis, prostate CA flareup
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Ganirelix
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GnRH antagonist analog. No initial increase in LH, faster induction of chem castration.
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Cabergoline
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D2 agonist. Treats prolactinomas, infertility/galactorrhea assoc with hyperprolactinemia, acromegaly
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Levothyroxine
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thyroxine T4
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Liothyronine
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triiodothyronine T3
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Liotrix
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4:1 mix of T4:T3
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Propylthiouracil
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inhibits thyroid peroxidase. Inhibits organification and also inhibits peripheral deiodination of T4 (5deiodinase). SE = agranulocytosis, rash
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Methimazole
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inhibits thyroid peroxidase. Inhibits organification. 10X more potent. SE = agranulocytosis, rash
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Iodide
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high doses reduce hormone release. Inihibit coupling of MIT+DIT = Wolf-Chiakoff effect. Given p radiation exposure. SE = brassy taste and salivary gland swelling.
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131 I-Na
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take up an dincorporated in thryoid where Beta irradiation then destroys the local tissue. 80% become hypothyroid.
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KI
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treats thyroid storm where there is an acute exacerbation of thyrotoxicosis and you get inc Beta receptors.
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Insulin Lispro
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rapid acting
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Insulin Aspart
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rapid acting
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Regular Insulin
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short acting. Used to treat DKA
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Insulin Lente
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intermediate acting
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NPH
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Neutral protamine hagedorn. Protamine and insulin equal. Intermediate acting
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Insuline Glargine
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long acting. Sub q injection, maintains over 24 hours = depot
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Detemir
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long acting insulin. Background insulin. Give 1-2 per day
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Tolbutamide
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1st gen SU. 2.5 increased risk of cardio death. Contra I for all SU = DM I, pregnancy, stress, sx, infection, renal/hepatic impair
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Chlorpropamide
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1st gen SU. Contra I for all SU = DM I, pregnancy, stress, sx, infection, renal/hepatic impair
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Tolazamide
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1st gen SU. Most slowly absorbed
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Glyburide
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2nd gen SU. 100X more potent than 1st gen.
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Repaglinide
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Meglitinide. Insulin secretagogue. Rapid onset, short duration, given before meals, Does not effect the ATP senstive K channels in cardiac and skeletal muscle. Metab via liver and kidney.
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Nateglinide
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Meglitinide. Insulin secretagogue. Rapid onset, short duration, given before meals, Does not effect the ATP senstive K channels in cardiac and skeletal muscle. Metab via liver and kidney. Doesn’t affect those who are normo-glycemic.
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Metformin
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Biguanide. Targets insulin resistance not secretion. Activates AMPK. Dec hepatic glucose output, increases insulin sensitivity, decreases TGs and choles, incr HDL, dec weight. SE = anorexia, nausea, vomiting. No hypoglycemia. NOT metabolized. Contra I in renal/hep impairment, alc abuse, heat/resp insufficiency, or any hypoxic condition b/c of lactic acidosis risk.
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Thiazolidinediones
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EX| rosiglitazone (any azone). Insulin sensitizer via PPARgamma activation. Act by inc receptor kinase activity, inc receptor phosphorylation, dec hepatic gluconeogenesis, inc glucose uptake. AE = slow, weight gain, fluid retention, heart failure
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Acarbose
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alpha glucosidase inhibitor
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Miglitol
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alpha glucosidase inhibitor
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Pramlintide
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analogue of amylin. Amylin is secreted at same time as insulin and it slows gastric emptying, promotes satiety, inhibits glucagon
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Exenatide
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GLP-1 analogue. Incretin that increases insulin release and inhibits glucagon release. Causes weight loss. Incretinsa are inactivated by DPP-4
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Sitagliptin
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incretin. Inhibitor of DPP-4.
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Estrone Sulfate
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conjugated estrogen, po, absorbed in lower GI (after they've been hydrolyxed by the flora), predominant drug used for post meno pausal HRT
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Equline Sulfate
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conjugated estrogen, po, absorbed in lower GI (after they've been hydrolyxed by the flora), predominant drug used for post meno pausal HRT
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Estradiol Valerate
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esterified estrogen, parenteral in oil, slow release/prolonged delivery. Used to induce pubertal changes in hypogonadal girls
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Estradiol Cypionate
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esterified estrogen, parenteral in oil, slow release/prolonged delivery. Used to induce pubertal changes in hypogonadal girls
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Ethinyl Estradiol
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synthetic steroidal estrogen, po, decreases 1st pass, long t1/2, used in combo OCP.
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Mestranol
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synthetic steroidal estrogen, po, decreases 1st pass, long t1/2, used in combo OCP.
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Diethylstilbesterol (DES)
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synthetic non steroidal, prolonged effects, palliative tx for advanced prostate or breast cancer after therapies have failed. Causes uterine CA if given to fetus
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Medroxyprogesterone Acetate
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21 carbon analog similar to progesterone. Supports pregnancy, anti-aldosterone effects, inhibits LH and FSH. Given PO for post meno HRT
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Megestrol Acetate
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21 carbon analog; stimulate appetite and weight gain in pts with AIDS
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19-nortestosternone derivatives
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EX| norethindrone, levonorgestrel, norethynodrel, desogestrel, norgestimate, dienogest. Good PO bioavailability, cause decidual change in endometrium, do not support pregnancy, inhibitors of LH/FSH release, used in combo oral contraceptive pills, progestin alone mini pills, contraceptive patches, emer post coital. Androgenic SE's (acne, facial hair...)
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Drospirenone
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spironolactone-rltd progestin. Anti-mineralcorticoid activity similar to progesterone. No androgenic activity. Doesn’t cause as much water retention as other pills
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Ulipristal Acetate
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selective progesterone receptor modulator (SPRM). Agonist/antagonist effets. Used for emer contraception
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Testosterone ethanate
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esterified testosterone. Used to induce pubertal change/maturation in hypogonadal boys. Converted to T p release from oil vehicle. No hepatotoxicity, abuse potential. Injected IM q 2-4wks
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Testosterone Cypionate
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esterified testosterone. Used to induce pubertal change/maturation in hypogonadal boys. Converted to T p release from oil vehicle. No hepatotoxicity, abuse potential. Injected IM q 2-4wks
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Orally Active Androgens
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EX| methyl testosterone, fluoxymesterone, oxandrolone. Aka Anabolic Steroids. All have 17-alkyl subsitution. Dose rltd hepatoxicity. Cause inc muscle mass and inc male sex organ growth
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Danazol
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synthetic steroid derivative with 17ethinyl group. PO use. Treats endometriosis. Inhibits ovarian fxn by decreaseing LH/FSH. Prevent episodes of hereditary angioneurotic edema in pts with complement C1 inhibitor deficiency.
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Levonorgestrel
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Plan B - post coital OCP. 80% effective when w/I 72 hrs. Can cause nausea.
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Ulpristal Acetate
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Ella - post coital OCP. 5 day course, 60% effective when w/I 120 hrs. Prevents ovulation and impairs implantation. Causes HA, nausea, dysmennorhea.
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Flutamide
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androgen receptor antagonist. Used to treat prostate CA w/o testicle removal. Used in combo w GnRH super agonist.
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Bicalutamide
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androgen receptor antagonist. More potent and longer acting, less hepatoxic. Both agents cause inc plasma testosterone due to impaired feedback inhibition. Can cause gynecomastia.
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Spironolactone
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weaker androgen receptor antagonist. Can tx hirsutism and acne. Reduces levels of steroid 17alpha hydroxylase in females
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Ketoconazole
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systemic antifungal. Inhibit multiple steroidigenic enzymes to dec androgen and corticosteroids. Can be used for CA tx. Inhibits 17A-hydroxylase, C17,20 lyase, SCC, 3B-hydrogenase, 11B-hydroxylase. Used to tx Cushings
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Finasteride
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5alpha reductase inhibitor. Prevents dihydrotestosterone synthesis. Tx BPH, male baldness. Can cause sexual dysfxn. Produces gynecomastia. (all anti-androgens produce gynecomastia).
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Dihydrotestosterone (DHT)
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potent androgen derived from testosterone. Can cause male baldness.
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Tamoxifen
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nonsteroidal, estrogen-R antagonist. Marked breast CA survival/prevention, treats osteoporosis, infertility. 1st line against ER+ brease CA. Estrogen agonist on bone, partial agonist on uterus. SE = inc DVT risk, inc uterine cancer risk.
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Raloxifene
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estrogen-R antagnoist on breast, agonist on bone. Used to tx post meno osteoporosis. Reduces risk of fractures. Has less risk of uterine CA and does NOT increase risk of breast CA. But does have risk of thromboembolism.
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Clomiphene
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estrogen-R antagonist. Used only for infertility. Estrogen receptor block leads to loss of estrogen feedback inhibition in women with good production of LH/FSH but can't release them take it so the negative feedback causes increased release of LH/FSH. Taken for 12 days
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Anastrozole
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Inhibits aromatase (CYP19) --> the p450 that is involved in converting androgens to estrogen. No estrogen agonist effects. Used to tx breast CA resistant to tamoxifen therapy. 1st line for ER+ breast CA. MORE effective than tomoxifen. SE = osteoporosis.
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Fluvestrant
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COMPLETE estrogen receptor block (antagonist). May reduce estrogen receptor level. Parenteral for breast CA. SE = osteoporosis
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Mifepristone
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aka RU486. Progesterone receptor antagonist used to induce 1st tri abortion. Also blocks glucocorticoid receptors. Single dose of it is given 2 days later with misprostol (PGE1 analog) --> stimulates uterine contraction to expulse embryo (PGE only given if needed). AE = nausea, vomit, diarrhea, vaginal bleeding.
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Aspirin
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COX1/2 Irreversible block. Analgesic, antipyretic, antiinflammatory. Block platelet aggre, reduces risk of colon CA. SE = GI irritation/ulcer, hemorrhage, renal tox, tinnitus, disturb acid-base balance. Note that blocked PGE synthesis causes enhanced histamine release --> HCl secretion.
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Propionic Acids
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EX| ibuprofen (all "fen's"), naproxen. Block COX1/2 reversibly. Analgesic, anti pyretic, anti-inflammatory. Contraindicated with nasal polyps.
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Chondroitin sulfate
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used to treat osteoarthritis. Can also use glucosamine, NSAIDS, glucocorticoid inj.
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Methotrexate
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cytotoxic, inhibits prolif of T and B cells. Treat RA and CA (at low doses). Reduces pain, swelling, dec incidence of new bone erosion. AE = nasal, GI ulcers, dose rltd hepatoxicity --> cirrhosis; blood dyscrasias
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Leflunomide
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similar to methotrexate. Converted to active metabolite in HI. Inhibits enzyme in pyrimidine synthesis (dihydroorotate dehydrogenase). Selective for T cells. Used for RA. SE = diarrhea, hepatotoxicity, alopecia and rarely leukopenia, thrombocytopenia.
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Adalimumab
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IgG anti-TNF monoclonal Ab. Blocks TNF ability to bind its R. Downreg macrphage and T cell fxn. Decreases rate of new RA erosions, reduced pain, swelling, used in combo with methotrexate. SE = infection, rare leukopenia.
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Infliximab
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IgG anti-TNF monoclonal Ab. Used in combo w methotrexate. Tx RA, Crohns. SE = infection, rare leukopenia. Contra-I in MS due to rare demyelinating syndrome with it.
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Etanercept
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fusion protein of two TNF-R subunits linked to Fc portion of IgG. Inhibits TNF and lymphotoxin-alpha. Used with methotrexate. Tx's RA, psoriasis, chronic juvenile arthritis.
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Anakinra
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IL-1 R antagonist. Used to tx juvenile RA
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Abatacept
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inhibits T cell activation by blocking APCs. Prevents APC CD80 interaction with T cell CD28. Tx's RA.
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Rituximab
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Ab that targets CD 20 on Bcells. Inhibits cell mediated and completment activation of B cells. Used to treat unresponse RA in combo with methotrexate
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Cyclosporin
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immunosuppressant used to treat RA.
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Aurothiomalate
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gold salt. Reduces pain and swelling, reduces RA progression. Highly toxic and rarely used. Other last resorts for RA are chloroquine and hydroxychloroquines (antimalarials)
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Calcitonin
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binds receptors on osteoclasts to inhibit bone resorption. Via intranasal spray or parenterally. Less effective than other therapies but it is very safe. Has analgesic effect on bone pain
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Etidronate
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1st gen bisphosphonate that inhibits mineralization and high doses can produce osteomalacia. PO. Treats hypercalcemia from a variety of causes like malignancy, Paget's dz. Palmidronate is the parenteral version.
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Alendronate
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and ibandronate, risedronate, tiludronate, zolendronate. New bisphosphonates used to tx osteoporosis. SE = gastric, esoph, upper GI irritation. Osteonecrosis of jaw = SE. Rapid IV injecton can produce acute kidney failure. Bisphosphonates are poorly absorbed with food and should be taken at least 30 min before meals.
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Denosumab
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monoclonal Ab to RANK-L. Blocks osteoclast activation by osteoblasts. Tx osteoporosis. Parenteral.
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Teriparatide
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synthetic PTH. High doses promote bone resorption but low doses stimulate bone formation and produce large increases in bone mass. Decrease risk of fracture. Daily SubQ injections. Increases freq of bone remodeling cycle
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Calcitriol
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Vit D derivatives. used for DO of hypocalcemia, 2ndary hyper parathyroidism, malabsorption.
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Cinacalcet
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calcimimetic that activates the Ca sensing G protein receptor that inhibits PTH release. Used in 2ndary hyperPTH to block PTH release.
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Fludrocortisone
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treatment for chronic adrenal insufficiency (Addison's disease). Preferential effect on MCR @ low doses
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Dexamethasone
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give high dose for 2 days. If 50% dec in cortisol, then it’s an Ant Pit defect (cushing dz). If not change in cortisol, then measure ACTH. Low = adrenal cortex lesion, High = ectopic source of ACTH
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Mitotane
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cytotoxic to adrenal cortical cells. Used to tx inoperable carcinoma of the cortex.
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Aminoglutethimide
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inhibits P450 side chain cleavase and 11B-hydroxylase. Used to treat overproduction in Cushings.
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Metyrapone
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inhibits 11B-hydroxylase. Blocks glucorticoid and MCR pathways. But since it acts so distally you get a build up of proximal molecules
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Cyclosporin A (CsA)
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immunophilin = cyclophilin; target = calcineurin; effect = inhibit CN --> inhibits dephosphorylation of NFAT --> blocks IL2 syn
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FK506 (Tacrolimus)
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immunophilin = FKAB; target = calcineurin; effect = inhibit CN --> inhibits dephosphorylation of NFAT --> blocks IL2 syn
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Rapamycin
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immunophilin = FKAB; target = mTOR; effect = inhibits p70S6 kinase --> dec cyclins/CDK --> stops cells from entering the S phase (from G1) --> decr in clel prolif
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Mycophenolate mofetil
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inhibits denovo synthesis of purines via inhib of inosine monophophate dehydrogenase.
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Azathioprine
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anti-metabolite. Looks like a purine and thus blocks purine syn. Toxic to BM. Low therapeutic window
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Rhogam
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IgG anti-Rh D: passive immunization against Rh Ag. Given to mother within 72 hrs p birth.
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Ipratropium Bromide
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non selective anti cholinergic. Slow onset. Reverses bronchoconstriction. More useful to tx COPD
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Tiotropium Bromide
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M1 and M3 selective anti cholinergic. 30 min onset. Efficacy gradually increases and peaks p 1 wk
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Inhaled Corticosteroids
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beclomethasone, diflusinide, budesonide, ceclesonide, triamcinolone, fluticasone, mometason furoate. Anti inflammatory, topically active but poorly absorbed. SE = oral thrush, dysphonia. Systemic SE = worsened asthma, osteoporosis, growth retardation, adrenal insufficiency. They can increase expression of beta-receptors.
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Safirlukast
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leukotriene antagonist
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Montelukast
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leukotriene antagonist
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Zileutin
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5-lipoxygenase inhibit. Requires liver fxn testing.
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Cromolyn
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Cromolyn and Nedocromil| prophylactic. Inhibit Ag and exercise induced bronchospasm. Stabilize mast cell degranulations. Most effective in extrinsic asthma. AE = hoarseness and sore throat
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Omalizumab
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aka Xolair; monoclonal anti IgE Ab. Binds Fc region. Not anaphylactogenic. Reduces free IgE but NOT total IgE. Reduces eosinophils
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Mepolizumab
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anti IL5 monoclonal Ab for persistent eosinophilic asthma. Month infusions. Reduces exacerbations.
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Cyclophosphamide
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aka Ifosfamide. Broad spectrum alkylating agent. Activated by P450 to 4hydroxy cyclophosphamide to aldophosphamide which is taken up by cells and then to phosphoramide + acrolein mustard. Cytotoxic effects by alkylating guanine residues of DNA. AE = CNS stim, BM suppress, GI tox, alopecia, hemorragic cystitis, bladder CA.
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Melphalan
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alkylating; not vesicant, reversible suppression of granulocyte/platelet fxn, broad spec, no alopecia,
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Chlorambucil
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alkylating; not vesicant, reaches distant sites, gradual cytotoxic effects, least BM suppression, tx choice for CLL. Increases incidence of 2ndary CA.
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Thiotepa
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aka Hexamethylmelamine (HMM). Alkylating agent, requires acid to be catalyzed and is more active.
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Bisulfan
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alkylating agent, selective, almost no other action aside from myelosuppression. Good for CML. Results in large cell kill. SE = hyperuricemia but can be prevented if you give allopurinol. Pts have sense of well being and incr appetite.
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Procarbazine
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alkylating agent; microsomal oxidation yields azoprocarbazine and H2O2. Given PO or IV. Can cross BBB. BM depression, nausea, vomiting, weak MAO-I (so be careful with CNS depressants, EtOh, etc..). Induces 2ndary CA. Used to tx Hodgkins, myeloma, and oat cell carcinoma.
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Dacarbazine
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alkylating agent, activated by P450 and dizaomethane is formed spontaneous in target cells. Inhibits RNA/protein syn. Crosses BBB. SE = n/v, flu like sydnrome during treatment, alopecia. Tx malig melanoma, hodgkins.
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Nitrosoureas
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ex| carmustine, lomustine, semustine. Activated in vitro to form alkylating agent which inhibits DNA syn. Forms isocyantes which Inhibit DNA repair. Delayed BM suppressant, crosses BBB, SE = n/v, vesicant. Treats meningeal leukemia.
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Streptozocin
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and chlorozotocin. Nitrosoureas with less n/v. Does NOT form isocynates. Affinty for B cell of Langerhans. Tx pancreatic tumor and malig carcinoid. SE = n/v, BM supress, anemia, renal/hepatic toxicity
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Cisplatin
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aka carboplatin. Alykating agent that has Cl/ammonia attached to platinum in cis config. Binds DNA strands and primary site is guanine. Non cell cycle specific. Given IV, diffuses into cells, 90% binding, poor CNS penetration. Good for epi cell type tumors. AE = n/v, distal tub necrosis, tinnitus, hearing loss (high f), periph neurop, anaphylactis, myelosuppression.
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Methotrexate
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acts by inhibiting dihydrofolate reductase. Prevent formation of THF. Produces remission in leukemia/choriocarcinoma. Also used for breast CA. AE = BM, GI mucosa, alopecia, fetus/reproductive organs, nephro hepatotoxicity, interstitial pneumonitis. Leucovorin rescues MTX.
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Fluorouracil
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aka 5-FU, Floxuridine. Halogenated analog of uracil. Converted to Fd-UMP --> then inhibits thymidylate synthase and forms a complex with methylene THF. Floxuridine is directly converted to Fd-UMP by thymidine kinase. AE = myelosupression, delayed GI tox, alopecia, Hand and Food Syndrome (reddening), acute cerebellar ataxia.
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Cytarabine
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arabinose analog of cytidine and deoxycytidine. Competes for incorp into DNA. S phase specific. Involves deoxycytidine kinase. AE = myelosuppression, nausea, more toxic to granulocytes than lymphocytes, mucositis, alopecia. Tx for AML.
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Purine Analogs
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ex| mercaptopurine and thioguanine. Sulfur analogs of hypoxanthine and guanine. Substrates for HPGRT but not guanylate kinase. TG can be given with allopurinal since its not dept on xanthine oxidase directly. AE = BM suppression, anorexia, n/v, hyperuricemia. Tx acute leukemia.
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Pentostatin
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inhibits adenosine deaminase. Cladribine and Fludarabine phophorylate are resistant to adenosine deaminase. All interfere with DNA syn by inhibiting DNA poly or ribonucleotide reductase. AE = BM suppression, Pento and CdA reduce CD4 --> used to treat hairy cell leukemia. Fludarabine usedful for CLL and non hodgkins.
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Hydroxyurea
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analog of urea. Inhibits ribonucleotide diphosphate reductase. This catalyzes ribonucleotides --> deoxyribonucleotides -- a crucial rate limiting step in DNA syn. Act in S phase. AE = BM suppression, megaloblastic anemia, GI disturbances, rarely alopecia, derm rxn, inflamm and pigmentation with irradiation. Used for CML
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Vinca Alkaloids
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EX| vinblastine and vincristine; M phase specific. Bind to tubulin and terminate assembly of mitotic spindles by blocking ability of tubulin to polymerize into microtubules. Metab by liver and excreted in bile. AE= neurop and BM suppression
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Vincristine
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neurotox, CNS, dec DTR, foot drop, ANS (constipation, orthostatic, hypotension, urine retention), alopecia
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Vinblastine
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BM suppression, n/v, mucositis, siADH --> hyponatremia
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Paclitaxel (Taxol)
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binds to tubulin at Beta site and promotes assembly of micro tubules. Stabilizes polymerization in absence of GTP. Acts in M phase. BM suppression and sensory neurop, treat malig melanoma, carcinoma of ovary,
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Epipodophylotoxins
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EX| Etoposide and Teniposide. Bind to tubulin but the cell is arrested in G2. Probably due to dec activity of topoisomerase II which cleaves the DNA in S phase. Resistance due to p-glycoprotein.
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Bleomycin
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intercalate with DNA bases, inhibit RNA poly, decrease topoisomerase II, and free radical production --> DNA scission. G2 specific. Binds DNA guanine bases and cause strand scission. Acts in skin and lung b/c degraded by hydrolase elsewhere. AE = blistering palms, alopecia, pulm fibrosis. Tx sq cell carcinoma, head, neck, skin, GU testicular tumoe and lymphomas
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Anthracyclines
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tetracycline with daunosamine attached by glycosidic linkage. Danorubicin useful for acute leukemias only. Doxorubicin useful for solid tumors, carcinomas, sarcomas, lymphoma, and acute leukemia. Binds to DNA via intercalation, DNA strand scission, semiquinone free rad generation, inhibitor of topoisomerase II, bind membrane -->alter fluidity/ion transport.
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Dimercaprol
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a dithiol, lipophilic in oil vehicle, injected IM, used in combo with CaNa-EDTA for acute lead toxicity (mobilizes and lowers lead in CNS). Can be used as a single agent treatment for arsenic poisoning or acute mercury poisoning.
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Succimer
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a dithiol, water soluble analog of dimercaprol. Given PO, much less toxic, single agent oral tx for mild lead toxicity in adults, asymptomatic childhood Pb poisoning, single agent for mild arsenic or mercury poisoning.
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CaNa2-EDTA
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NH2 and COOH groups bind metal. H2O soluble, given IV, excreted unchanged by the kidney, given as calcium-disodium salt to avoid chelation of plasma Ca2+, used in combo with dimercaprol for acute Pb toxicity.
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Penicillamine
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used to treat or prevent copper poisoning in Wilson's dz
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Deferoxamine
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treats acute iron poisoning. Binds iron w/o displacing iron in heme-containing proteins.
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Deferasirox
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orally active Fe chelating agent used to treat chronic iron tox (hemochromatosis) that isn't responsive to phlebotomy therapy.
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Prussian Blue
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insoluble chelating agent with high affinity for Cesium and Thallium. Prevent their absorption. Stockpiled in case of terrorism.
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Hydroxocobalamin
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used to treat cyanide poisoning
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Isotretinoin
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synthetic retinoid used to treat acne. Contra I in pregnancy!
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Aciretin
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synthetic retinoid used to treat psoriasis. Contra I in pregnancy!
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