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27 Cards in this Set

  • Front
  • Back
TCA's?
imipramine, amitriptyline, desipramine, nortriptyline
drugs that inhibit reuptake transporters of NE and 5HT?
TCAs, amoxapine, maprotiline, trazodone, duloxetine, venlafaxine
this drug inhibits the reuptake of 5HT more than NE
trazodone
MOA of mirtazapine?
increases amine release from presynaptic neuron by antagonizing presynaptic alpha2 receptros involved in feedback inhibition
class of antidepressants that increase vesicular stores of NE and 5HT by inhibiting their metabolism in the nerve endings?
MAO-Is
long term use can decrease BP
MAOIs
common CNS effect of TCAs and some heterocyclics, esp mirtazapine and trazodone?
sedation
drugs more likely to cause CNS stimulation than sedation?
SSRIs, MAOIs, bupropion
TCAs with greatest antimuscarinic receptor blockade?
amitriptyline, doxepin
drugs used for pts with significant anxiety, phobias, hypochondriasis?
MAOIs
drugs that lower seizure threshold?
TCAs and MAOIs
antidepressant class that is most tolerable and has greatest safety in overdose?
SSRIs
most effective antidepressant class?
TCAs
antidepressants also used to treat bipolar disorder, panic attacks, phobias, enuresis, ADHD, and chronic pain?
TCAs
drugs used for pain syndromes?
TCAs, venlafaxine, duloxetine
drugs used in OCD, generalized anxiety disorders, panic attacks, social phobias, bulimia, premenstrual dysphoric disorder and alcohol dependence?
SSRIs
drug used to manage pts attempting to withdraw from nicotine?
bupropion
TCA side effects
1. excessive sedation, fatigue
2. sympathomimetic effects - tachycardia, agitation, sweating, insomnia
3. atropine-like effects
4. orthostatic hypotension, EKG abnormalities, cardiomyopathies
5. tremor, paresthesias
6. weight gain
Heterocyclic antidepressant that is a dopamine recepor blocker and may cause akathisia, parkinsonism, amenorrhea-galactorrhea syndrome?
Amoxapine
heterocyclic that causes anxiety, agitation, dizziness, dry mouth, aggravation of psychosis, and, at high doses, seizures?
bupropion
third gen heterocyclics that are inhibitors of P450 enzymes?
venlafaxine and nefazodone
class of drugs that cause nausea, headache, anxiety, agitation, insomnia, and sexual dysfxn?
SSRIs (fluoxetine)
class of drug that inhibits P450 enzymes?
SSRIs
major toxic effect of citalopram overdose?
QT prolongation
toxic effect of interaction between fluoxetine and MAOIs?
serotonin syndrome
(rigidity, myoclonus, hyperthermia, CV instability, CNS stimulation, seizures)
drugs used to treat serotonin syndrome seen in MAOI/SSRI interaction?
antiseizure drugs, muscle relaxants, 5HT blockers (cyproheptadine)
toxic effect seen in pts on MAOIs who consume tyramine-containing foods?
hypertensive crisis