Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
TCA's?
|
imipramine, amitriptyline, desipramine, nortriptyline
|
|
drugs that inhibit reuptake transporters of NE and 5HT?
|
TCAs, amoxapine, maprotiline, trazodone, duloxetine, venlafaxine
|
|
this drug inhibits the reuptake of 5HT more than NE
|
trazodone
|
|
MOA of mirtazapine?
|
increases amine release from presynaptic neuron by antagonizing presynaptic alpha2 receptros involved in feedback inhibition
|
|
class of antidepressants that increase vesicular stores of NE and 5HT by inhibiting their metabolism in the nerve endings?
|
MAO-Is
|
|
long term use can decrease BP
|
MAOIs
|
|
common CNS effect of TCAs and some heterocyclics, esp mirtazapine and trazodone?
|
sedation
|
|
drugs more likely to cause CNS stimulation than sedation?
|
SSRIs, MAOIs, bupropion
|
|
TCAs with greatest antimuscarinic receptor blockade?
|
amitriptyline, doxepin
|
|
drugs used for pts with significant anxiety, phobias, hypochondriasis?
|
MAOIs
|
|
drugs that lower seizure threshold?
|
TCAs and MAOIs
|
|
antidepressant class that is most tolerable and has greatest safety in overdose?
|
SSRIs
|
|
most effective antidepressant class?
|
TCAs
|
|
antidepressants also used to treat bipolar disorder, panic attacks, phobias, enuresis, ADHD, and chronic pain?
|
TCAs
|
|
drugs used for pain syndromes?
|
TCAs, venlafaxine, duloxetine
|
|
drugs used in OCD, generalized anxiety disorders, panic attacks, social phobias, bulimia, premenstrual dysphoric disorder and alcohol dependence?
|
SSRIs
|
|
drug used to manage pts attempting to withdraw from nicotine?
|
bupropion
|
|
TCA side effects
|
1. excessive sedation, fatigue
2. sympathomimetic effects - tachycardia, agitation, sweating, insomnia 3. atropine-like effects 4. orthostatic hypotension, EKG abnormalities, cardiomyopathies 5. tremor, paresthesias 6. weight gain |
|
Heterocyclic antidepressant that is a dopamine recepor blocker and may cause akathisia, parkinsonism, amenorrhea-galactorrhea syndrome?
|
Amoxapine
|
|
heterocyclic that causes anxiety, agitation, dizziness, dry mouth, aggravation of psychosis, and, at high doses, seizures?
|
bupropion
|
|
third gen heterocyclics that are inhibitors of P450 enzymes?
|
venlafaxine and nefazodone
|
|
class of drugs that cause nausea, headache, anxiety, agitation, insomnia, and sexual dysfxn?
|
SSRIs (fluoxetine)
|
|
class of drug that inhibits P450 enzymes?
|
SSRIs
|
|
major toxic effect of citalopram overdose?
|
QT prolongation
|
|
toxic effect of interaction between fluoxetine and MAOIs?
|
serotonin syndrome
(rigidity, myoclonus, hyperthermia, CV instability, CNS stimulation, seizures) |
|
drugs used to treat serotonin syndrome seen in MAOI/SSRI interaction?
|
antiseizure drugs, muscle relaxants, 5HT blockers (cyproheptadine)
|
|
toxic effect seen in pts on MAOIs who consume tyramine-containing foods?
|
hypertensive crisis
|