Pharm 3 Abx Etc

Front 1

protein synth inhibs
bacterialcidal

Back 1

aminogylcoside
linezolid

Front 2

bad incorpration of a.a.
bacteriostatic

Back 2

tetracyclines
dalforpristin
quinupristin
no insettion of tRNA into A site

Front 3

interfere w/ peptide bond
bacteriostatic

Back 3

cam
inhib peptidyltransferase

Front 4

interference w. translocation
bacteriostatic

Back 4

macrolide
clindomycin
peptydil tRNA cant go to donor site

Front 5

inhib of folic acid synth

Back 5

sulfonamide
trimethoprim and pyrimethamine

Front 6

inhib of nucleic acid

Back 6

fluroquinolones
inhib gyrase topo2
rifampin
inhib DNA dep RNA pol

Front 7

Resistence MOA

Back 7

-blatam ring cleavage(pcn,cephalosporin)
-conj enzymes that inc drug clearence (aminoglycs)
-acetylating enzymes (cam)
-methylation of RNA ( macrolides)
-active transport that pushes drug out of cell (tetracyclines)
-inc resistance to dihydropterate (sultonamide)
-inc transport systems to push out and inhib topo2 (fluroquin)

Front 8

pcn+aminoglycosides

Back 8

synergistic effect
1+1=3

Front 9

pcn+tetracycline

Back 9

antagonistic effect
1+1=0
for pneumococcal meningitis

Front 10

staph and strep tx

Back 10

pcn k=po
pcn g=iv/im

Front 11

s. auerus resistant to pcn

Back 11

tx w. oxcacillin(IV)
cloxacillin
dicloxacillin
nafcillian(IV)

Front 12

MRSA

Back 12

resistant to ox,clox,diclox,naf
tx w/ vanc

Front 13

tx for strep and gm neg

Back 13

amoxacillin and amp

Front 14

strep, pseudomonas and gm neg

Back 14

pipercillian,ticarcillin,carbenicillin

Front 15

everything + s. aureus

Back 15

beta lactamase inhibs:
clavuanate and sulbuctam

Front 16

gm pos and gm neg not MRSA

Back 16

amoxacillin/clauvlanate
amp/sulbactam
piperacillin/tazobactam
ticarcillin/clauvulnate

Front 17

cefazolin

Back 17

surgical prophylaxis
1st gen cephalosporin
gm pos

Front 18

cephalothin

Back 18

renal tube nec
no cns entry
1st gen ceph
gm pos

Front 19

cefotetan

Back 19

tx gm neg
tx for bacteroid fragilis
disulfram action
2nd gen ceph
no cns entry

Front 20

cefaclor

Back 20

gm neg
serum sickness
2nd gen ceph
no cns entry

Front 21

cefoperazone

Back 21

gm neg and pseudomonas
no cns entry
3rd gen :
cause pseudomemb colitis
ceftriaxone IV x 1= gonorrhea
billiary sludge

Front 22

cefepime IV

Back 22

for gm pos
4th gen

Front 23

cephlasporins and renal failure

Back 23

dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more

Front 24

if pt allergic to pcn and is gm pos

Back 24

macrolides

Front 25

if pt allergic to pcn and is gm neg

Back 25

aztreonam

Front 26

Aztreonam

Back 26

for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn

Front 27

carbapenems

Back 27

imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure

Front 28

Vanc

Back 28

for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid

Front 29

side affecs of vanc

Back 29

redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity

Front 30

ERM

Back 30

macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int

Front 31

azith

Back 31

does what erm does
used for chlamydial urethritis

Front 32

clarithro

Back 32

does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450

Front 33

telithromycin

Back 33

related to macrolides
like azyth
inc QT int
inhib cyto p 450

Front 34

tetracyclines

Back 34

tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use

Front 35

demeclocycline

Back 35

inhib ADH so tx for SIADH
can cause DI

Front 36

doxycycline

Back 36

goes thru the prostate for prostitis

Front 37

fluroquinolones

Back 37

floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes

Front 38

cephlasporins and renal failure

Back 38

dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more

Front 39

if pt allergic to pcn and is gm pos

Back 39

macrolides

Front 40

if pt allergic to pcn and is gm neg

Back 40

aztreonam

Front 41

Aztreonam

Back 41

for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn

Front 42

carbapenems

Back 42

imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure

Front 43

Vanc

Back 43

for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid

Front 44

side affecs of vanc

Back 44

redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity

Front 45

ERM

Back 45

macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int

Front 46

azith

Back 46

does what erm does
used for chlamydial urethritis

Front 47

clarithro

Back 47

does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450

Front 48

telithromycin

Back 48

related to macrolides
like azyth
inc QT int
inhib cyto p 450

Front 49

tetracyclines

Back 49

tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use

Front 50

demeclocycline

Back 50

inhib ADH so tx for SIADH
can cause DI

Front 51

doxycycline

Back 51

goes thru the prostate for prostitis

Front 52

fluroquinolones

Back 52

floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes

Front 53

cephlasporins and renal failure

Back 53

dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more

Front 54

if pt allergic to pcn and is gm pos

Back 54

macrolides

Front 55

if pt allergic to pcn and is gm neg

Back 55

aztreonam

Front 56

Aztreonam

Back 56

for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn

Front 57

carbapenems

Back 57

imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure

Front 58

Vanc

Back 58

for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid

Front 59

side affecs of vanc

Back 59

redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity

Front 60

ERM

Back 60

macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int

Front 61

azith

Back 61

does what erm does
used for chlamydial urethritis

Front 62

clarithro

Back 62

does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450

Front 63

telithromycin

Back 63

related to macrolides
like azyth
inc QT int
inhib cyto p 450

Front 64

tetracyclines

Back 64

tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use

Front 65

demeclocycline

Back 65

inhib ADH so tx for SIADH
can cause DI

Front 66

doxycycline

Back 66

goes thru the prostate for prostitis

Front 67

fluroquinolones

Back 67

floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes

Front 68

aminoglycosides

Back 68

gent,tobra,neo,strepto
tx gm neg

Front 69

endometiritis

Back 69

gent+amp+metronidizole

Front 70

enterococcus

Back 70

aminoglyc synergistic w/ amp

Front 71

pseudomonal inf

Back 71

amino synergistic w/ ext spectrum pcn

Front 72

side effects of aminogylcs

Back 72

ototoxicity
nephrotox->vanc,cyclosporinamphotercin B
neruomusc blockade
need to dose adjust w/ renal failure->loops make it worse

Front 73

sulfisoxazole

Back 73

tx uti
nocardial inf

Front 74

sulfasalazine

Back 74

tx uc

Front 75

sulfacetamide

Back 75

tx trachoma
topical

Front 76

silver sulfadiazine

Back 76

burns

Front 77

sulfadiazine+pyrimethamine

Back 77

to toxoplasmosis

Front 78

trimethoprin/sulfamethoxazole

Back 78

tx PCP

Front 79

sulfa side effects

Back 79

hypersensitivities-steve johnson
g6pd def
crystalluria
dont use 3rd trimester of preg=cross BBB=kernicterus
inc warfarin and phenytoin

Front 80

trimethorprin/sulfamethoxazole tmz-smx

Back 80

doc prophylaxis and tx for pcp
effects:
thrombocyto,leukopenia,gi probs,hemolysis

Front 81

methenamine mandelate and nitrofurantoin

Back 81

urinary tract antiseptics

Front 82

phenazopyridine

Back 82

urinary tract anelgesics

Front 83

amphotericin B

Back 83

-polyene antifungal
-iv for serious inf
-tx aspergilus,candida,cryptocooc,histoplas
-binds to ergosterol
-nephrotoxic,hypokalemia
normo anemia
-flu symps
-dec ergosterol lvls
-goes to csf
-synergistic w/ fluocytosine

Front 84

Azoles

Back 84

-block synth of ergosterol by inhib 14 a;pha demethylase
-dec intracell lvl of drugs
-tx po candida,coccid,paracoccid,blastomyc,histo

Front 85

clotrimazole/miconazole

Back 85

-topically
-candidna,derm inf

Front 86

ketoconazole

Back 86

-gynocomastia
-dec libido,menst irreg

Front 87

itraconazole

Back 87

no csf
abs inc by food

Front 88

griseofulvin

Back 88

-intferes w/ mitotic spindle by mts
-tx tinea curis
-dont use w/ intermittint pyphoria

Front 89

terbinafine

Back 89

-inhib squalene epxadase
-tx onchomycosis
-inc lft

Front 90

flucytosine

Back 90

inhib thymidydlate synthase=dec thymine

Front 91

amantadine

Back 91

-interfere w/ attachment,penetration,and uncoating
-tx flu A and parkinsons
-causes livedo reticularis
and anticholinergic

Front 92

ribavirin

Back 92

-inhobs viral rna pol
-inhibs end capping of viral mrna
-tx rsv
-teratogenic

Front 93

acyclovir

Back 93

-inhib viral dna pol
-dec activity to viral thymidilate kinase
-tx herpes,shingles,
nephropathy,neurotoxicity,crystalluria

Front 94

famciclovir/valacylovir

Back 94

tx herpes

Front 95

ganciclovir

Back 95

-tx cmv
-viral thymidylate kinase in herpes
-phosphotransferase in cmv
-leukopenia,thrombocytopenia
-seizure if overdose

Front 96

foscarnet

Back 96

-inhib dna pol
-tx cmv retinitis in aids,
-nephrotoxicity
-w/pentamindine will cause severe hypercalcemia

Front 97

zanamivir/oseltamivir

Back 97

-inhib neuraminidase of influ A&B
-prophylaxis to dec flu symps

Front 98

nucleoside rev transcriptase inhib

Back 98

-phosphorylated to triphosphate that inhib rt
-specific pt mutation in rt gene

Front 99

zidovodine AZT

Back 99

bm surprression
peripheral neuropathy
lactic acidosis

Front 100

diadanosine DDI

Back 100

pancreatitis
hyperurecemia

Front 101

stavudine D4T

Back 101

peripheral neuropathy

Front 102

zalcitabine DDC

Back 102

periph neuropathy

Front 103

lamivudine 3TC

Back 103

-gi distress
-1st choice for hep b sAG from bld

Front 104

nonnucleoside rev trans inhib

Back 104

delavirdine
nevirapine
efavirenz
-no bm supression

Front 105

protease inhibs

Back 105

inhib aspartate protease by binding to dipeptide
abn lipid CHO metab=insulin resistance

Front 106

indinavir

Back 106

PI
nephrolithisis
hyperbillirubinemia
inhib of p450

Front 107

ritonavir

Back 107

PI
inhib p450
gi probs
inc effect of dronabinol and rifampin

Front 108

nelfinavir

Back 108

PI
gi probs

Front 109

saquinavir

Back 109

PI
gi probs

Front 110

when to start tx for AIDS

Back 110

cd4<500
viral load >10,000
so give 2 nuc inhibs and 1 prot inhib

Front 111

prophylaxsis

Back 111

cd4>500 and ppd pos

Front 112

prophylaxis for pcp

Back 112

trimethoprim
dapsone
pentamidine

Front 113

give azithroycin/clarithro

Back 113

CD <75
prevent MAC

Front 114

gancyclovir

Back 114

<50
cmv prevention

Front 115

ndl stick /one time sex w/ HIV pt.

Back 115

2+1x4wks

Front 116

female w/ cd4 of >500
load of <400

Back 116

nothing

Front 117

female preg >500 <200

Back 117

AZT

Front 118

preg female cd4 1 load>700,000

Back 118

2+1
PCP,MAC,CMV

Front 119

isoniazid

Back 119

-inhib of mycolic acid synth
-resistance by acyl carrier prot
-or del of kat g
-anti tb drug
-cause hepatitis,g6pd def,neuritis so give b6

Front 120

rifampin

Back 120

-inhibs dna dep rna pol
-mutation in pol enzyme=resistance
-induce p450
-thrombocytopenia
anti tb drug

Front 121

ethambutol

Back 121

-inhibs synth of arabinogalactam
-causes retrobulbar neuritis

Front 122

pyrazinomide

Back 122

artrhralgia
hepatotx
inc porphyrin synth

Front 123

aminoglycosides

Back 123

inhib prot synth

Front 124

capreomycin

Back 124

2nd choice of tx for resistant tb

Front 125

azyth+rifabutin+ethambutol

Back 125

tx for aids and tb or mac