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125 Cards in this Set

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  • Back
protein synth inhibs
bacterialcidal
aminogylcoside
linezolid
bad incorpration of a.a.
bacteriostatic
tetracyclines
dalforpristin
quinupristin
no insettion of tRNA into A site
interfere w/ peptide bond
bacteriostatic
cam
inhib peptidyltransferase
interference w. translocation
bacteriostatic
macrolide
clindomycin
peptydil tRNA cant go to donor site
inhib of folic acid synth
sulfonamide
trimethoprim and pyrimethamine
inhib of nucleic acid
fluroquinolones
inhib gyrase topo2
rifampin
inhib DNA dep RNA pol
Resistence MOA
-blatam ring cleavage(pcn,cephalosporin)
-conj enzymes that inc drug clearence (aminoglycs)
-acetylating enzymes (cam)
-methylation of RNA ( macrolides)
-active transport that pushes drug out of cell (tetracyclines)
-inc resistance to dihydropterate (sultonamide)
-inc transport systems to push out and inhib topo2 (fluroquin)
pcn+aminoglycosides
synergistic effect
1+1=3
pcn+tetracycline
antagonistic effect
1+1=0
for pneumococcal meningitis
staph and strep tx
pcn k=po
pcn g=iv/im
s. auerus resistant to pcn
tx w. oxcacillin(IV)
cloxacillin
dicloxacillin
nafcillian(IV)
MRSA
resistant to ox,clox,diclox,naf
tx w/ vanc
tx for strep and gm neg
amoxacillin and amp
strep, pseudomonas and gm neg
pipercillian,ticarcillin,carbenicillin
everything + s. aureus
beta lactamase inhibs:
clavuanate and sulbuctam
gm pos and gm neg not MRSA
amoxacillin/clauvlanate
amp/sulbactam
piperacillin/tazobactam
ticarcillin/clauvulnate
cefazolin
surgical prophylaxis
1st gen cephalosporin
gm pos
cephalothin
renal tube nec
no cns entry
1st gen ceph
gm pos
cefotetan
tx gm neg
tx for bacteroid fragilis
disulfram action
2nd gen ceph
no cns entry
cefaclor
gm neg
serum sickness
2nd gen ceph
no cns entry
cefoperazone
gm neg and pseudomonas
no cns entry
3rd gen :
cause pseudomemb colitis
ceftriaxone IV x 1= gonorrhea
billiary sludge
cefepime IV
for gm pos
4th gen
cephlasporins and renal failure
dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more
if pt allergic to pcn and is gm pos
macrolides
if pt allergic to pcn and is gm neg
aztreonam
Aztreonam
for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn
carbapenems
imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure
Vanc
for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid
side affecs of vanc
redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity
ERM
macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int
azith
does what erm does
used for chlamydial urethritis
clarithro
does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450
telithromycin
related to macrolides
like azyth
inc QT int
inhib cyto p 450
tetracyclines
tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use
demeclocycline
inhib ADH so tx for SIADH
can cause DI
doxycycline
goes thru the prostate for prostitis
fluroquinolones
floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes
cephlasporins and renal failure
dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more
if pt allergic to pcn and is gm pos
macrolides
if pt allergic to pcn and is gm neg
aztreonam
Aztreonam
for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn
carbapenems
imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure
Vanc
for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid
side affecs of vanc
redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity
ERM
macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int
azith
does what erm does
used for chlamydial urethritis
clarithro
does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450
telithromycin
related to macrolides
like azyth
inc QT int
inhib cyto p 450
tetracyclines
tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use
demeclocycline
inhib ADH so tx for SIADH
can cause DI
doxycycline
goes thru the prostate for prostitis
fluroquinolones
floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes
cephlasporins and renal failure
dose adjustment
xept ceftriaxone and cefoperazone
liver metabs more
if pt allergic to pcn and is gm pos
macrolides
if pt allergic to pcn and is gm neg
aztreonam
Aztreonam
for gm neg
monobactam
for pseudomonas aregousa
inhibs transpeptidation
give iv
can use if allergic to pcn
carbapenems
imipenem/cilastatin
imp is rapidly metab by renal dipeptidase
cil inhibs renal dipeptidase=inc action of imipen
==> meropenem
tx serious infection
for gm neg,pos, anerobes
side effects:
renal dysfxn and seizure
Vanc
for gm pos only
inib of bact cell wall
bactericidal
iv kills mrsa
will kill c diff but dont choose it.
resistant form is VRE use linezolid
side affecs of vanc
redman syndrome
ototoxicity
hypersensitivity
nephrotoxicity
ERM
macrolide
tx legionella,mycoplasma
effects:
diarrhea n/v
inc QT int
azith
does what erm does
used for chlamydial urethritis
clarithro
does what erm does
for h.influ and h.pylori
best for mycobact avium complex
inhib of cyto p450
telithromycin
related to macrolides
like azyth
inc QT int
inhib cyto p 450
tetracyclines
tx chlamydia,ricketsia,mycoplasma,brucella, yersinia,vibro
for allergic to pcn
no dariy xept dox or minocyc
ototoxicity
fanconi syndrome
if kid <8 dont use
demeclocycline
inhib ADH so tx for SIADH
can cause DI
doxycycline
goes thru the prostate for prostitis
fluroquinolones
floxins and enoxacin
like nalidixic acid
doc for anthrax
tx gm neg sepsis
dont use w/ <18 =inhib of chondrocytes
aminoglycosides
gent,tobra,neo,strepto
tx gm neg
endometiritis
gent+amp+metronidizole
enterococcus
aminoglyc synergistic w/ amp
pseudomonal inf
amino synergistic w/ ext spectrum pcn
side effects of aminogylcs
ototoxicity
nephrotox->vanc,cyclosporinamphotercin B
neruomusc blockade
need to dose adjust w/ renal failure->loops make it worse
sulfisoxazole
tx uti
nocardial inf
sulfasalazine
tx uc
sulfacetamide
tx trachoma
topical
silver sulfadiazine
burns
sulfadiazine+pyrimethamine
to toxoplasmosis
trimethoprin/sulfamethoxazole
tx PCP
sulfa side effects
hypersensitivities-steve johnson
g6pd def
crystalluria
dont use 3rd trimester of preg=cross BBB=kernicterus
inc warfarin and phenytoin
trimethorprin/sulfamethoxazole tmz-smx
doc prophylaxis and tx for pcp
effects:
thrombocyto,leukopenia,gi probs,hemolysis
methenamine mandelate and nitrofurantoin
urinary tract antiseptics
phenazopyridine
urinary tract anelgesics
amphotericin B
-polyene antifungal
-iv for serious inf
-tx aspergilus,candida,cryptocooc,histoplas
-binds to ergosterol
-nephrotoxic,hypokalemia
normo anemia
-flu symps
-dec ergosterol lvls
-goes to csf
-synergistic w/ fluocytosine
Azoles
-block synth of ergosterol by inhib 14 a;pha demethylase
-dec intracell lvl of drugs
-tx po candida,coccid,paracoccid,blastomyc,histo
clotrimazole/miconazole
-topically
-candidna,derm inf
ketoconazole
-gynocomastia
-dec libido,menst irreg
itraconazole
no csf
abs inc by food
griseofulvin
-intferes w/ mitotic spindle by mts
-tx tinea curis
-dont use w/ intermittint pyphoria
terbinafine
-inhib squalene epxadase
-tx onchomycosis
-inc lft
flucytosine
inhib thymidydlate synthase=dec thymine
amantadine
-interfere w/ attachment,penetration,and uncoating
-tx flu A and parkinsons
-causes livedo reticularis
and anticholinergic
ribavirin
-inhobs viral rna pol
-inhibs end capping of viral mrna
-tx rsv
-teratogenic
acyclovir
-inhib viral dna pol
-dec activity to viral thymidilate kinase
-tx herpes,shingles,
nephropathy,neurotoxicity,crystalluria
famciclovir/valacylovir
tx herpes
ganciclovir
-tx cmv
-viral thymidylate kinase in herpes
-phosphotransferase in cmv
-leukopenia,thrombocytopenia
-seizure if overdose
foscarnet
-inhib dna pol
-tx cmv retinitis in aids,
-nephrotoxicity
-w/pentamindine will cause severe hypercalcemia
zanamivir/oseltamivir
-inhib neuraminidase of influ A&B
-prophylaxis to dec flu symps
nucleoside rev transcriptase inhib
-phosphorylated to triphosphate that inhib rt
-specific pt mutation in rt gene
zidovodine AZT
bm surprression
peripheral neuropathy
lactic acidosis
diadanosine DDI
pancreatitis
hyperurecemia
stavudine D4T
peripheral neuropathy
zalcitabine DDC
periph neuropathy
lamivudine 3TC
-gi distress
-1st choice for hep b sAG from bld
nonnucleoside rev trans inhib
delavirdine
nevirapine
efavirenz
-no bm supression
protease inhibs
inhib aspartate protease by binding to dipeptide
abn lipid CHO metab=insulin resistance
indinavir
PI
nephrolithisis
hyperbillirubinemia
inhib of p450
ritonavir
PI
inhib p450
gi probs
inc effect of dronabinol and rifampin
nelfinavir
PI
gi probs
saquinavir
PI
gi probs
when to start tx for AIDS
cd4<500
viral load >10,000
so give 2 nuc inhibs and 1 prot inhib
prophylaxsis
cd4>500 and ppd pos
prophylaxis for pcp
trimethoprim
dapsone
pentamidine
give azithroycin/clarithro
CD <75
prevent MAC
gancyclovir
<50
cmv prevention
ndl stick /one time sex w/ HIV pt.
2+1x4wks
female w/ cd4 of >500
load of <400
nothing
female preg >500 <200
AZT
preg female cd4 1 load>700,000
2+1
PCP,MAC,CMV
isoniazid
-inhib of mycolic acid synth
-resistance by acyl carrier prot
-or del of kat g
-anti tb drug
-cause hepatitis,g6pd def,neuritis so give b6
rifampin
-inhibs dna dep rna pol
-mutation in pol enzyme=resistance
-induce p450
-thrombocytopenia
anti tb drug
ethambutol
-inhibs synth of arabinogalactam
-causes retrobulbar neuritis
pyrazinomide
artrhralgia
hepatotx
inc porphyrin synth
aminoglycosides
inhib prot synth
capreomycin
2nd choice of tx for resistant tb
azyth+rifabutin+ethambutol
tx for aids and tb or mac