Pharm 3

Front 1

Bethanechol

Back 1

Class: choline esters, direct agonist
Use: atonic intestine, urinary retention, reflux esophagitis
Target: m3AChR
most frequently used
Action: muscarinic at therapeutic doses

Front 2

Methacholine

Back 2

Class: choline esters, direct agonist
Use: atonic intestine, urinary retention, reflux esophagitis
Target: m3AChRAction: muscarinic at therapeutic doses

Front 3

Carbechol

Back 3

Class: choline esters, direct agonist
Use: atonic intestine, urinary retention, reflux esophagitis
Target: m3AChR
Action: muscarinic at therapeutic doses

Front 4

Pilocarpine

Back 4

Class: cholinergic alkaloids
Use: glaucoma
Action: contract ciliary muscle
SE: pupil constriction, increased GI motility, diarrhea

Front 5

Muscarine

Back 5

Class: cholinergic alkaloids

Front 6

Arecoline

Back 6

Class: cholinergic alkaloids
Use: glaucoma
SE: betl nut poison

Front 7

Neostigmine

Back 7

Class: reversible carbamates, indirect agonists
Use: atonic bladder, glaucoma, competitive NM blocker, adjunt in anesthesia, LT Tx of MG
Longer Duration
Action: indirect agnoist with nicotinic nad muscarinic effects
SE: tremors, restlessness, anxiety, coma

Front 8

Physostigmine

Back 8

Class: reversible carbamates, indirect agonists
Use: atonic bladder, glaucoma, competitive NM blocker, adjunt in anesthesia, LT Tx of MG
Target: treat atropine poisoning, tricyclic antidepressants, heriditary ataxias
Action: indirect agnoist with nicotinic nad muscarinic effects
SE: tremors, restlessness, anxiety, coma

Front 9

Edrophonium

Back 9

Dx of MG

Front 10

Pyrodostigmine

Back 10

used with atrophine

Front 11

Diisoprophylphoorofluoridate

Back 11

Class: irreversible (organophosphorus), cross BBB
Use: glaucoma
SE: death due to paralysis of diaphragm

Front 12

Parathion, malathion

Back 12

Class: irreversible (organophosphorus), cross BBB
Use: insecticides
SE: death due to paralysis of diaphragm

Front 13

Sorman/Sarin

Back 13

Class: irreversible (organophosphorus), cross BBB
Use: nerve gas
SE: death due to paralysis of diaphragm

Front 14

Trating OP poisoning

Back 14

pralidaxoine: reversible AChE inhibitors
Atropine: combats Sx

Front 15

Effects of cholinergic agonists

Back 15

decrease HR, lower BP, miosis, diaphoretic, increase HCl seretion in stomach, increase GI motility, sphincter relaxation, induce micturation, CNS arousal

Front 16

Atropine

Back 16

Class: muscarinic blockers, anti-muscarinics, Belladonna alkaloids
Indication: pupil dilator exam, tx for nerve gas/insectiside, acute bradycardia (IV)
Action: counteracts organophosphate poisoning

Front 17

Scopolamine

Back 17

Class: muscarinic blockers, anti-muscarinics, Belladonna alkaloids
Tx: motion sickness
SE: crosses BBB

Front 18

Atropine + Scopolamine

Back 18

Class: muscarinic blockers, anti-muscarinics, Belladonna alkaloids
Use: pre-anesthesia to reduce salivation

Front 19

Methscopolamine

Back 19

Class: Cholinergic antagonist, synthetic analogs
Use: acute brady arrythmia, acute MI, bronchodilator, pupil dilator, prevent motion sickness, Tx of paraplegics with incontinence, parkinson tremor

Front 20

Dicyclomine, glycopyrrolate, methantheline, propantheline

Back 20

Class: Cholinergic antagonist, synthetic analogs
Use: GI ulcers and colitis, Glyco only treats ulcers

Front 21

Ipratropium

Back 21

Use: same as pamine
Action: bronchodilator antagonizing parasympathetic mediated bronchoconstriction

Front 22

General effects of muscarinic antagonists

Back 22

mydriasis, reduces sweat, reduce GI motility, increase HR, bronchodilation and reduce secretions, drowsiness and hallucination

Front 23

Trimethaphan
Mecamylamine
Hexamethonium

Back 23

Class: ganglionic blockers
Use: acute HTN, pul edema, sub-arrachnoid hemorrhage, venodialatory effects IV

Front 24

Adrenergic Agonists

Back 24

Use: acute HF, type I hypersensitivity (shock), hemostatic with local anesthetics

Front 25

EPI, Isoproterenol

Back 25

Class: beta agonist
Indication: cardiac stimulant, bronchodilator
S/I: contraindicated in diabetics

Front 26

Dobutamine

Back 26

Class: beta agonist
Use: cardio emergency
Target: beta-1

Front 27

Metaproterenol
terbutaline
albuterol
isoetharine
fenoterol
ritodrine
salmeterol

Back 27

Class: beta agonist
Use: bronchodilator in asthmatics, may inhibit inflammatory mediator release
Target: beta-2

Front 28

Epinephrine
Ephedrine
Metaraminol
Methoxamine

Back 28

Class: alpha agonist
Use: increase BP

Front 29

Mephenteramine

Back 29

Class: alpha agonist
Use: increase BP and decongestant

Front 30

NE
Phenylephrine
Pseudoephedrine

Back 30

alpha-agonist
decongestant

Front 31

Tetrhydrozoline

Back 31

Class: alpha agnoist
Use: ophthalamic decongestant

Front 32

Clonidine

Back 32

Class: alpha-2 specific
Use: treat HTN
Target: presynaptic alpha-2 receptor agonist
Action: antagonist to symphathetic Fxn by decreaseing NE release
SE: fluid absorption, decrease NaCl

Front 33

d-amphetamine
metamphetamine

Back 33

Class: indirect agonist, alphaR
indication: shock, hypotension during anesthesia
target: depletors of NE from CNS, stimulate resp center
action: alertness, wakefullness, decrease fatigue, elation
SE: restlessness, dizziness, termors, irritaion, insomnia
Chronic SE: dependence and tolerance

Front 34

Beta blockers

Back 34

indication: vasodilation
Target: blockade of SNS flow from CNS, suppression of NE release, blockade of post-synaptic receptors

Front 35

Prazosin
Terazosin

Back 35

Class: alpha1 blocker, adrenergic antagonist
Use: HTN
Target: alpha-1

Front 36

Doxazosin

Back 36

Class: alpha1 blocker, adrenergic antagonist
Use: HTN, benign prostate hyperplasia
Target: slpha1

Front 37

Phentolamine

Back 37

Class: alpha1 blocker, adrenergic antagonist
Use: dx pheocromocytoma
Target: alpha1

Front 38

Yohimbine

Back 38

Class: alpha1 blocker, adrenergic antagonist
Use: male impotence
Target: alpha2

Front 39

Clonidine

Back 39

Sympathetic blocker
Use: vasodilator (CNS)
Target: presynaptic alpha2
Action: antagnoist to sympathetic Fxn by decreasing NE/Epi release

Front 40

Propranolol

Back 40

Class: general beta blocker
Use: HTN, ventricular arrhythmias, migraine
Target: beta1, beta2
Contra: diabetes

Front 41

Labetalol

Back 41

beta blocker
use: HTN
Target: beta1, beta2

Front 42

Nadolol

Back 42

Class: beta blockers
Use: HTN, angina
Target: beta1, beta2

Front 43

Pindolol

Back 43

Class: beta blocker
Use: HTN
Target: beta1, beta2

Front 44

Timolol

Back 44

Class: beta blockers
Target: beta1, beta2
Use: HTN, post MI

Front 45

Atenolol

Back 45

Class: beta1 blockers
Use: HTN, angina

Front 46

Acebutolol

Back 46

Class: beta1 blockers
Use: HTN

Front 47

Bisoprolol

Back 47

Class: beta1 blockers
Use: ventric arrhythmias

Front 48

Esmolol

Back 48

Class: beta1 blockers
Use: HTN, supraventricular tachycardia

Front 49

Metoprolol

Back 49

Class: beta1 blockers
Use: tachycardia, HTN, angina