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20 Cards in this Set

  • Front
  • Back
Toxins
- substances produced by BIOLOGICAL systems such as plants and animals
Toxicants
- toxic substances produced by human activities
Toxidrome
- toxicologic syndromes
- signs and symptoms consistently associated with specific toxic agents
Risk
- expected frequency of the occurrence of an undesidrable effect arisign from exposure
Hazard
- ability of a chemcial agent to cause injury in a given situation or setting
Potentiation
- special form of synergism
- when a chemical that itself produces no effect increases the toxicity of another
ABCD's of poison TX
- A= airway
- B= breathing must be assessed
- C= circulation
- D= Dextrose - given to pts with altered mental status
Decontamination
- skin
- GI:
emesis
gastric lavage
catharsis
activated charcoal
Enhanced elimination of toxicants
- changing urinary pH
- dialysis
- hemoperfusion
- hemodialysis
Antidote:
Bind to the toxicant and inactivate it
- chelators for metals posoning
- antibody fragments for digoxin overdose
Antidote:
Block critical receptor
- naloxone for opioid agents
- atropine for anticholinesterases
Antidote:
change toxicant metabolism
- N-acetylcysteine increases deactivation of acetamonphen toxic metabolite
- ethanol competititvely inhibits conversion of methanol to more toxic formaldehyde and formic acid
- how are these good???
Antidote:
Reversal of the viochemical damage produced by the toxicant
- pralidoxime reverses phosphorylation produced by anticholinesterase insecticide poisoning and reactivates enzyme
Antivenin
- snake or spider bite
Atropine
- cholinesteerase inhibitors and lots of stuff
deferoximine mesylate
- iron poisoning
dimercaprol (BAL)
- arsenic, mercury, gold, lead
EDTA
- lead
naloxone (narcan)
- opioids
d-penicillamine
- copper