Pharm 3

Front 1

alpha 2 agonist

Back 1

decrease SANS outflow , AE- edema and CNS dep , DI- TCA decrease antiHTN effects

Front 2

clonidine

Back 2

alpha 2 agonist, opiate withdrawal

Front 3

methyldopa

Back 3

alpha 2 agonist, HTN in preg women , AE- + coombs

Front 4

reserpine

Back 4

intereferes with storage vesicles, SEVERE DEPRESSION, increased GI secretions , depletes NE, 5HT, DA

Front 5

guanethidine

Back 5

inhibits NE release, AE- TCA block reuptake

Front 6

alpha 1 blocker

Back 6

decrease arteriloar ad venous resiscntace, reflexc tachycarida, -zosin, USE- HTN and BPH, AE- orthostatic hypotention and urinary incon, good lipid profile

Front 7

B blockers

Back 7

CI- diabetics, vasopsoams, asthma

Front 8

hydralazine

Back 8

decrease TPR via arteriolrar dilation,SLE like syn, use for pregnancy , act via NO2

Front 9

nitroprusside

Back 9

AE- CN toxicity, use- HTN emergecy , act via NO2

Front 10

minoxidil

Back 10

arteriolar vasoldation, open K channles , USE- male baldness(rogaine) AE- diabetogenic(decreases insulin)

Front 11

CCBs

Back 11

antiartyhmic, HTN, angina, AE- ginigival hyperplasia(dipines), verampil

Front 12

verampil

Back 12

CCB that works on hrt , AE- constipation

Front 13

DIPINE

Back 13

CCB that works on blood vessel

Front 14

dialtezam

Back 14

CCB that can work on hert and blood vessel

Front 15

captopril

Back 15

ACEI, blocks form of Ang II, AE- dry cough, hyperkalemia, ARF, angioedema , USE- mild to mod HTN, CHF

Front 16

losaratan

Back 16

block AT1 receptor, no dry cough , USE- mild to mod HTN, CHF

Front 17

aliskerin

Back 17

renin inhibitors, no dry cought, USE- mild to mod HTN

Front 18

ANTI HTN in angina

Back 18

B blockers, CCBs

Front 19

ANTI HTN in diabetes

Back 19

ACEI, ARBs

Front 20

ANTI HTN in HF

Back 20

ACEI, ARBs, Beta blockers

Front 21

ANTI HTN in post MI

Back 21

B blockers

Front 22

ANTI HTN in BPH

Back 22

alpha blockers

Front 23

ANTI HTN in dyslpipidemia

Back 23

alpha blockers, CCBs, ACEI/ ARB

Front 24

Bosetan

Back 24

vasoconstrictior, CI- pregnancy ,USE- pu; HTN

Front 25

epoprosteronol

Back 25

infusion pump for pul HTN

Front 26

sildenafil

Back 26

PDE inh, increased cGMP, USE- pul HTN

Front 27

methoxamine

Back 27

paraxysmal atrial tachycarida through vagal refelx

Front 28

isoproteronol

Back 28

B1 and B3 agonist, USE- bronchospasm and AV block, AE0 flushing

Front 29

Dobutamine

Back 29

B1 agonsit, USE- CHF

Front 30

selevctive B2

Back 30

salemterol, albuterol, terbutaline used in asthma

Front 31

methy phenidate

Back 31

use in narcolepsy and ADHD, displaces NE from mobile pool

Front 32

reuptake inhibitor

Back 32

cocaine and TCA

Front 33

mirtazapine

Back 33

selective alpha 2 blocker, used as antidepressent, increases appetite- USE- anorexia

Front 34

timolol

Back 34

glaucoma , blocks action of NE, decrease aqueosu humor formation, for open glucoma

Front 35

propranol

Back 35

thyrotoxicosis, performance anxiety, essential tremor , essential trempor, agoraphobia, social phobia

Front 36

sotalol

Back 36

K channel blocking and B blocking , slows phase III, B 1 blockage, USE- life threatening ventricular arrthmias

Front 37

pilocarpine

Back 37

increases aqueous humor outflow, for glaucoma , M3- ocntraction of cilirary muscle

Front 38

Quinidine

Back 38

cinchonism(GI, ocular dysfunction, CNS exlciation), torsades, DI- hyperkalemia, toxic with digoxin, Class IA

Front 39

procainamide

Back 39

IA antiarrthmic, AE- SLE like syn, torsades , hematoxcity, thrombocytopenia

Front 40

IA antiarrthmic

Back 40

block open or activated state Na channels

Front 41

IB antiarrthmic

Back 41

preference for damaged tissue, prefers partially depoalzied tissue, lidocaine, mexiletene

Front 42

lidocaine

Back 42

IB, post MI, AE- sexiures, less cardiotxoicity

Front 43

mexiletine

Back 43

IB antiarrthmic

Front 44

flecainadie

Back 44

IC, increased sudden death,

Front 45

esmolol

Back 45

IV, acute SVTs, beta blocker

Front 46

B blocker as antiarthmcis

Back 46

prophylasix post MI, SVTs , decrease slope of phase 4 of AP in SA node

Front 47

Ventricular arrthmias

Back 47

IA, III

Front 48

SVTs

Back 48

II, IV

Front 49

III antiarthmics

Back 49

decreas IK(delayed rectified) sloe down phase 3, amiodarone, sotalol

Front 50

amiodarone

Back 50

I, II, III, IV, long half life, AE- pul fibrosis, hepatoxicity, thyroid dysnfcion, blue skin( high Vd)

Front 51

adenosine

Back 51

DOC for paroxysmal supraventricualr tachycardias and AV nodal arrythmias, short half life

Front 52

Magnesium

Back 52

USE- torsades

Front 53

digoxin

Back 53

inh of cardiac Na K ATPase, increased intracellular CA, increased contractile force , inhibition of neuronal NaK ATPase-->increased diastolic filing, INCREASED CONTRACTILITY , long half life, large tissue protein bomding, USE- CHF, SVT, AE- anorexia, CNS, arrthmias, MANGEMENT- Fab antibodies

Front 54

inamironone and milrinoine

Back 54

increase cAMP in hrt, increased ionotropy, increased cAMP in smooth muscle--> decreased TPR

Front 55

Nesiritide

Back 55

recomb BNP, increased cGMP , use for acute decompensated CHF

Front 56

nitroglycerin

Back 56

AE- orthostatic hypertension, tachyphylaxis, cadiotox with digoxin, USE- angina

Front 57

nefidipine

Back 57

CCB used for vaspospastic angina

Front 58

carvedilol

Back 58

angina of effort

Front 59

ranolazine

Back 59

blocks late inward Na current in cardiac myocytes decreasing Ca acculumation( Ca accumulates in ischemic tissue to due increased Na)

Front 60

theophylline

Back 60

PDE inhibitors, tx for status epilepticius, AE- carditoxicity

Front 61

Acetazolamide

Back 61

CA inh in PT, decreased H in PCT, increased Na and HCO3 in lumen,USE- galucoma, acute mountain sickes, metabolic alkalisis, AE- ACIDOSIS, RENAL STONES, SULFONAMIDE HYPERSENSITIVTY , dx- INCREASED HCO3 in urine

Front 62

Mannitol

Back 62

inhbits water reabsortions through out the tubule, increased urine volumne

Front 63

Ethacrinic acid

Back 63

loop diurecti, no allergies to sulfanamide, INCREASED Ca in urine

Front 64

Furosemide

Back 64

loop diurecti, allergies to sulfanamide, INCREASED Ca in urine , USE- acute pul edema

Front 65

Thiazides

Back 65

Na Cl transport inhibitor in EARLY DISTAL, USE- calcium stones, AE- HYPERCALCEMIA, nephrogenic DI , CI in diabetics but can be given as antihypertinces(works well with AA men) , drugs- indapamide, metolazone, hydrocholrothiazide

Front 66

Spironolactone

Back 66

early collecting duct , aldosterone antagonist, uSE- antiandrogenic, CHF, AE- hyperkalemia+acidosis

Front 67

Amiloride and triamterone

Back 67

Na channel blockers, USE-LI induced nephrogenic diabetes(amiloride), AE- hyperkalemia+acidosis

Front 68

Loops

Back 68

Na/K/Cl transport inhibitor in ASCENDING LIMB, INCREASED Ca in urine , ethacrinic acid, furosemide , USE- acute pul edema, ARF , AE- otoxicity, DI- aminoglycosides(increased otoxictiy), lithium, digoxin

Front 69

lovastatin

Back 69

HMG CoA reductase, MOA- decreased VLDL synthesis and decreased LDL, AE- rhabdomyolysis, hepatoxicity, DI with gemfibrozil(increased rhabdomyolsis), increased toxcitiy with CYP 450 inh

Front 70

cholestryamine and colestipol

Back 70

bile acid sequenstrant, increaed LDL expression, AE- increased VLDL and TAGs, MALABSORPTION OF FAT SOLUBLE VITAMINS , CI- hypertriglycerderimia

Front 71

niacin

Back 71

inhibition of VLDL syntehsis, decreased VLDL, AE- intesse PRURITIS made better with aspirin

Front 72

gemfibrozil, fenofibrate

Back 72

fibrates, bind to PPAR alpha and increase expression of lipoprotein lipases, increases HDL in most pts, USE- hypertriglycedemia, AE- gall stones, myositis

Front 73

ezetimibe

Back 73

prevents intestinal reabsorption of cholestrol

Front 74

drug for increased cholestrol

Back 74

cholestryamine, colestipol, ezetimibe

Front 75

drug for increased TAG

Back 75

gemfibrozil

Front 76

drug for increased cholestrol and triglycerides

Back 76

statins, niacin, ezetimibe

Front 77

alprozolam

Back 77

anxiety, panic phobias

Front 78

diazepam

Back 78

anxiety, muscle relaxant

Front 79

lorazepam

Back 79

anxiety, status epilepticus , not metabolized by liver

Front 80

midazolam

Back 80

preop sedation, anesthesia , anterograde amnesia(BZ2)

Front 81

teazepam and oxazepam

Back 81

sleep disorder benzo , not metabolized by liver

Front 82

phenobarbitol

Back 82

barbituate, DOC for epilepsy during pregnancy

Front 83

thiopental

Back 83

short acting, anesthesia, barbituate , works on GABA A(Cl), complex I inhibitor

Front 84

zolpidem and zaleplon

Back 84

BZ1 receptor agonist, sleep disorders(less effect on cognition)

Front 85

barbituates

Back 85

CYP inducer, CI in porphyria

Front 86

busipirone

Back 86

5HTA partial agonist, used for GAD

Front 88

methanol

Back 88

results in formaldehyde- irreversible tisue damage, ocular damage, resp failure

Front 89

ethylene glycol

Back 89

reumts in production of oxalic acid, nephrotoic acid, CNS depression

Front 90

ethanol

Back 90

results in acetic acid, acetaldehyde combines with folate to inactivate it, combies with thiamine to decrease availability

Front 91

disulfiram

Back 91

inhibits acetaldehyde dehydrogenase, similar rxn with- metronidazole, griseofulvin, cefoperazone, cefotetan, chlorpropramide

Front 92

chronic alcoholism

Back 92

msucle wasting, gout, fatty liver, hypoglycemia

Front 93

Phenytoin

Back 93

blocks Na channel in their inactivated state, USE- seziures except absence, PK- zero order kinetics, AE- gingival hyperlasia, hirsuitism, osteomalacia, megaloblastic anemia, TERATOGENIC( cleft lip and palate)

Front 94

Carbamazepine

Back 94

blocks Na chaniinel in activated state, DOC- trigem neuralgia, used for manic bipolar disorder, PK- CYP 450 inducer, AE- INCREASED ADH, steven johnson syndrome, TERATOGENIC( spina bifida and cleft lip and palate)

Front 95

valproic acid

Back 95

GABA transaminas inibitor, blcokage of T type Ca channels, USE- migraine prophylaxis, mania of bipolar disorders, AE- pancreatitis, alopecia, TERATOGEIC( spina bifida)

Front 96

Ethosuximide

Back 96

blockage of T type Ca, USE- absence seizure, AE- decreased efficacy of oral contraceptives via CYP induction

Front 97

felbamate and lamitrigine

Back 97

block Na channels and glutamate receptors , AE- hepattoxcitiy and aplastic anemia(felbamate), steven johnson( lamotrigine)

Front 98

gabapentin

Back 98

increased GABA effects, USE- neuropathic pain

Front 99

NO2

Back 99

diffusion hypoxia, spon abortion, low blood gas, rapid onset and recovery, high MAC

Front 100

halothate

Back 100

low MAC, higher blood gas ratio, malignant hyperthermia, cardiac arrythmias

Front 101

profol

Back 101

antiemetic, anesthesia- initation and maitaines

Front 102

fentanyl

Back 102

opiate, anesteha

Front 103

ketamine

Back 103

dissociative anethesia, NMDA receptor antagonist, hallucination, increased ICP, vivid nightmares

Front 104

felbamate

Back 104

anesthetic blocking NMDA receptor

Front 105

tetrodotoxin

Back 105

puffer fish. Block inactivated Na channels, decreased Na influex

Front 106

ciguatoxin

Back 106

bind to activated Na channle, cause inactvation, prolong Na influx, desesensitixe and inactivate

Front 107

esters

Back 107

procaine, cocaine, cause allergeis due to PABA(paraaminobenzoic acid)

Front 108

amides

Back 108

lidocaine, bupivacaine

Front 109

local analgesics

Back 109

nonionized form crosses axoimanl membrane, from within ionized form blocks the inacticated Na channel, slows recovery and prevents propogation of action potentials, esters and amides, AE- cadiotxoic,, neruotoxic

Front 110

cocaine

Back 110

vasocontiction by blocking NE uptake

Front 111

tubocurarine

Back 111

competitive, non depol, reversible with AcHE, no CNS effects

Front 112

Atracurium

Back 112

nondepol blocker, safe in hepatic and renal impariment because spon inactiavation to laudanosine( this could cause seizures)

Front 113

mivacurium

Back 113

short duration nondepol blockers

Front 114

succinylcholine

Back 114

nicotinic agonist, noncome depol blocker, no effect of AchE when desenstivzed, AE- malignant hyperthermia, hyeperkalemia, genetic polymorphism(slow metabs could be problematic)

Front 115

baclofen

Back 115

GABA B receptors, use for spasticity

Front 116

dantrolene and bromocriptine

Back 116

tx for malig hyperthermia

Front 117

MAC

Back 117

lower MAC- more potennt

Front 118

blood gas ratio

Back 118

high- slower onset and slower recovery

Front 119

IV anethetics

Back 119

thiopental, midozolam, propodol, fentanyl, ketamine

Front 120

dantrolene

Back 120

blocks Ca release from muscle SR, tx for NMS

Front 121

CI in opids use

Back 121

head injuries, pul dysfunction(except pul edema), hepatic and renal dysfucntion, adrenal or thyroid def, pregnancy

Front 122

meripridine

Back 122

opioid full agnosit, antimuscardinic, met to normepridine-->serotonin syndrome and seziures

Front 123

methadone

Back 123

maintains opioid addiction

Front 124

codeine

Back 124

cough supressant

Front 125

dextromorphan

Back 125

opid related, cough supressant

Front 126

loperamide

Back 126

opoid rel, diarrhea

Front 127

opidoid management of withdrawal

Back 127

methadone and clonidine(decreases NE release)-->decreases SANs response

Front 128

opoid mgmt of acute txocitiy

Back 128

IC nalazone

Front 129

opoid withdrawal

Back 129

yawning, lacrimation, salivation, rhinorea, CNS origin, pain, anxiety, sweating, G I coulple, u- strongest

Front 130

nalbuphine and pentazocine

Back 130

K agonist- spinal analgesia and dysphoria, u antagonist- preciptation of withdrawal

Front 131

naloxone

Back 131

opoid antagonist, IV, reverse resp dep

Front 132

naltrexone

Back 132

decrease craving of alc and opiate addiction

Front 133

methylnaltrexone

Back 133

opioid anatgonist, opioid rel constipation

Front 134

DA agonist

Back 134

dyskinesia(hyper movement)

Front 135

DA antagonist

Back 135

pseudoparkinsosm(nigrostriatal) , gynecopastia, amenoreha/galactorreha (tuveroinfedibular)

Front 136

mesolimbic pathway

Back 136

cell bodies in midbrain, reiforcement of behavior increased DA in nucelus accumbens

Front 137

amporphine

Back 137

DA agonsit, emetic

Front 138

D1

Back 138

Gs

Front 139

D2

Back 139

Gi

Front 140

D2A

Back 140

nigrostriatal

Front 141

D2C

Back 141

mesolimbic , clozapine

Front 142

levodopa

Back 142

prodrug, converted by decarbozylase, give with carbidopa(inhbits peripheral decarboxylase) AE- dyskinesia, psychosis, hypotension

Front 143

tolcapone and entacapone

Back 143

inhibit COMT and enhances uptake and effciacy, tolcapone- hepatoxic

Front 144

seleginine

Back 144

MAO B selective inhbitor, NO TYRAMINE INTERACTION AE- dyskeniea, psychosis, amnesia(met by aphetamine- will test + in drug test)

Front 145

bromocriptine

Back 145

hyperprolactinoma and acromegaly , DA receptor acgonist , AE- psychosis and dyskinesia

Front 146

pramipexole and ropinirole

Back 146

DA receptor agonist

Front 147

benztropine, trihexyphenydyl, diphenhydramine

Back 147

decreases Ach function, muscarinic blocker, decreases tremor and rigidity, AE- antimuscarinic(atropine like)

Front 148

amantidine

Back 148

antiviral, blocks muscarinin increased DA release, AE- LIVEDO RETICULARIS

Front 149

antimuscarinic use in psychosis

Back 149

for acute EPS( pseduoparkinsonism, akathesia, dystonia)