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19 Cards in this Set
- Front
- Back
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most important drugs causing parkinsonism? |
butyrophenone, phenothiazine antipsychotics (both block brain DA receptors)
reserpine at high doses (depletes brain DA) MPTP (produced in basement meperidine analogs, destroys DA neurons) |
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drug that inhibits DOPA decarboxylase in peripheral tissue, given with levodopa?
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carbidopa
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drugs used to improve fluctuations in levodopa responses?
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entacapone, tolcapone
(catechol-O-methyltransferase inhibitors) |
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side effects of levodopa?
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anorexia, N/V, postural hypotension (esp early in tx)
dyskinesias (choreoathetosis, tics, etc) anxiety, agitation, confusion, delusions, halluciantions, depression |
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MOA of bromocriptine
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ergot alkaloids that are partial agonists at dopamine D2 receptors in the brain, increasing functional activity of DA pathways
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these side effects occur more often with bromocriptine than with levodopa
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behavioral effects (confusion, hallucinations, delusions)
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dopamine receptor agonists?
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bromocriptine, pergolide (ergot alkaloids)
pramipexole, ropinirole (nonergot agonists) apomorphine |
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DOC for early management of Parkinson's disease?
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pramipexole and ropinirole
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which DA receptor agonist should be reduced in renal dysfunction?
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pramipexole
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which DA receptor agonist should not be given with caffeine or warfarin?
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ropinirole (metabolized by same P450 enzyme)
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antiviral that prevents influenza A uncoating process also used to enhance DA neurotransmission?
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amantidine
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MOA of selegiline?
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MAO-B inhibitor
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which enzymes breakdown NE, 5HT and DA in the synapse?
which one breaks down DA preferentially? |
Monoamine oxidases
MAO-B |
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selegiline is contraindicated in the use with which other drug, as it may cause agitation, delirium and death?
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meperidine
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drugs that improve tremor and rigidity of parkinsonism but have little effect on bradykinesia?
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Antimuscarinic drugs (benztropine, trihexyphenidyl, biperiden)
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physiologic and essential tremor can be alleviated by what drugs?
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beta-blockers
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drugs used in Huntington's disease and Tourette's syndrome?
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Phenothiazines (reserpine, tetrabenazine - amine-depleting)
Haloperidol (DA receptor antagonist) |
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copper chelator used in Wilson's disease?
side effects? |
penicillamine
GI distress, myasthenia, optic neuropathy, blood dyscrasias |
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in addition to Parkinsonism, ropinirole is used to treat what?
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restless leg syndrome
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