Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
Common side effect of hypnotic agents
|
Sedation
|
|
|
Occurs when sedative hypnotics are used chronically or at high doses
|
Tolerance
|
|
|
The most common type of drug interaction of sedative hypnotics with other depressant medications
|
Additive CNS depression
|
|
|
Benzodiazepines used to promote sleep
|
Triazolam, Tem-aza-pam, Flu-raz-e-pam
|
|
|
Benzodiazepine used for anxiety
|
Alprazolam
|
|
|
Non-benzodiazepine used as an anxiolytic
|
Buspirone
|
|
|
Non-benzodiazepine used for sleep
|
Zolpidem
|
|
|
Major effect of benzodiazepines on sleep at high doses
|
Decreased REM
|
|
|
Neurologic SE of benzodiazepines
|
ANTEROgrade Amnesia
|
|
|
Reason benzos are used cautiously in pregnancy
|
Ability to cross the placenta
|
|
|
Main route of metabolism for benzodiazepines
|
Hepatic
|
|
|
Benzodiazepine that undergo extrahepatic conjugation (useful in older or hepatically impaired patients)
|
(LOTs) Lorazepam, Oxazepam, Temazepam
|
|
|
MOA for Benzodiazapines
|
Increase FREQUENCY of GABA-mediated Chloride Ion channel opening
|
|
|
Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
|
Flumazenil
|
|
|
Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
|
Diazepam
|
|
|
Benzodiazepine that has efficacy against absence seizures, and in anxiety states, such as agoraphobia
|
Clonazepam
|
|
|
Benzodiazepines that are the most effective in the treatment of panic disorder
|
Alprazolam, Clonazepam (Panic = Hot, Turn on the AC)
|
|
|
Benzo used in anesthesia
|
Midazolam
|
|
|
DOC for status epilepticus
|
Diazepam
|
|
|
Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs
|
(Alcoholics listen to CD's) Chlor-diaz-epoxide, Diazepam
|
|
|
Agents having active metabolites, long half lives, and a high incidence of adverse effects
|
(D [the] FCC) Diazepam, Flurazepam, Chlordiazepoxide, Clorazepate
|
|
|
Barbiturates may precipitate this hematologic condition
|
Acute Intermittent Porphyria
|
|
|
Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property
|
Liver enzyme INDUCTION
|
|
|
Barbiturates MOA
|
Increase the DURATION of GABA-mediated chloride ion channels
|
|
|
Barbiturate used for the induction of anesthesia
|
Thiopental
|
|
|
Site of action for zaleplon and zolpidem
|
Benzodiazepine receptor BZ1 (although are not considered benzodiazepines)
|
|
|
Good hypnotic activity with less CNS SE than most benzodiazepines
|
(get your ZZ's) Zolpidem (Ambien), Zaleplon (Sonata)
|
|
|
Partial agonist for the 5-HT1A receptor
|
Buspirone
|
|
|
DOC for Generalized Anxiety Disorder, NOT effective in acute anxiety
|
Buspirone
|
