Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
Class 1A
--Actions-- |
Blocks Na channel (intermediate)
Depress phase 0 Prolongs AP slows conduction velocity |
|
|
Class 1B
|
Blocks NA Channel (fast)
Shorten AP Little phase 0 effect |
|
|
Class 1C
|
Blocks Na Channel (slow)
marked depression phase 0 minimal AP effect slow conduction velocity |
|
|
Class 2
|
Beta Blockers
lower conduction velocity increase refractory period decrease automaticity |
|
|
Class 3
|
K channel blocker
decrease conduction velocity dramatic increase refractory period increase AP decrease automaticity increase PR duration increase QT duration |
|
|
Class 4
|
Ca Channel blocker
decrease AP |
|
|
Class 5
|
Direct nodal inhibition
|
|
|
Quinidine
-class -dose/max dose -uses -metabolism |
Class 1A
dose-200mg IV x 1 max dose- 5g/24 hours hepatic metabolism tx of chronic supervent dysrhymithas-25% afib conversion |
|
|
Procainamide
-class -dose/max dose -uses -metabolism |
Class 1A
dose-100mg Q5min max dose 500mg-1g SVT's not for atrial tachy's hepatic metabolism reduce dose for renal impairment |
|
|
Disopyramide
-class -dose/max dose -uses -metabolism |
Class 1A
dose PO 100mg q6 <50kg >50kg=150 Q6 suppresses atrial and vent dysrhymias |
|
|
Lidocaine
-class -dose/max dose -uses -metabolism |
Class 1B
50-100mg load iv. infusion 1-4mg/min max=200-300mg/hr tx or re-entry cardiac dysrhymias delays phase 4 hepatic metabolism |
|
|
Mexiletine
-class -dose/max dose -uses -metabolism |
1B
supression of tachydysrhythmias synergistic with B-blocker=decrease dose 200mg q8hours PO low 1st pass hepatic |
|
|
Tocainide
-class -dose/max dose -uses -metabolism |
Class 1B
PO 400-800mg Q8 synergistic with B-blockers tx of tachy ventdysrhymisa |
|
|
Phenytoin
-class -dose/max dose -uses -metabolism |
Class 1B
50-100mg q5min. max 15mg/kg or 1g. Narrow therapeutic index extensive protein binding |
|
|
Moricizine
-class -dose/max dose -uses -metabolism |
Class 1C
200mg PO Q8 PO |
|
|
Flecainide
-class -dose/max dose -uses -metabolism |
Class 1C
supressing PVC and vent tach prolongs QRS increases dig and propranolol concentration dose 50-100mg Q12 max 400/day hepatic metabolism |
|
|
Propafenone
-class -dose/max dose -uses -metabolism |
Class 1C
Beta and calcium channel effects dose 150-300mg Q8 PO Hepatic metabolism |
|
|
Propranolol
-class -dose/max dose -uses -metabolism |
Class 2
non selective beta 1 and beta 2 1-3mg iv Q2-5min. max 5mg PO 10-30mg every 6-8hours hepatic metabolism |
|
|
Metoprolol
-class -dose/max dose -uses -metabolism |
Class 2
selective beta 1 2.5-5mg Q2-5min. max 15mg iv extensive 1st pass hepatic |
|
|
Esmolol
-class -dose/max dose -uses -metabolism |
Class 2
short acting B1 selective svt=500mcg/kg/min for 4min maintenance 50mcg/kg/min must be given on pump |
|
|
Amiodarone
-class -dose/max dose -uses -metabolism |
Class 3
refractory svt and vent tachy lasts up to 60+ days prolonged QT 5mg/kg bolus convert to PO asap eg. 400x3, 200qd, etc hepatic metabolism |
|
|
Sotalol
-class -dose/max dose -uses -metabolism |
Class 3 over 160mg (2 otherwise)
nonselective betablocker decreases atrial and vent ectopy prolong QT 80mg bid up to 160bid PO done in hospital no metabolism |
|
|
Ibutilide
-class -dose/max dose -uses -metabolism |
Class 3
used for AFib/flutter-acute not chronic hepatic metabolism 1mg pts >60kg 0.01mg <60kg |
|
|
Dofetilide
-class -dose/max dose -uses -metabolism |
Class 3
maintain nsr after cardioversion |
|
|
Bretylium
-class -dose/max dose -uses -metabolism |
Class 3
refractory vent dysrhymias renal elimination |
|
|
Verapamil
-class -dose/max dose -uses -metabolism |
Class 4
svt 2.5-5mg iv over 2min followed my 5-10mg. max 20mg hepatic dosing for chrosis |
|
|
Diltiazem
-class -dose/max dose -uses -metabolism |
Class 4
0.25mg/kg x 1, 0.35mg/kg in 15min infusion start 10mg/hr. max 15mg/hour start PO within 3 hours of bolus |
|
|
Digitalis
-class -dose/max dose -uses -metabolism |
Class 5
0.25mg Q2h up to 1.5mg svt tx low thearaputic index |
|
|
Adenosine
-class -dose/max dose -uses -metabolism |
Class 5
1st line Psvt dose 6mg repeat q 1-2 min with 12mg |
|
|
Multaq
-class -dose/max dose -uses -metabolism |
Class 5
for afib/flutter 400mg bid PO increased risk for death with HF pts no renal or hepatic adjustment |
