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35 Cards in this Set

  • Front
  • Back
disease caused by excess ergot alkaloids
St. Anthony's fire
endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides
autocoids
syndrome of hypersecretion of gastric acid and usually caused by gastrinoma; associated with peptic ulceration and diarrhea
Zollinger-Ellison syndrome
drug that causes contraction of the uterus
oxytocin
distribution of histamine receptors H1, H2, and H3
H1: smooth muscle
H2: stomach, heart, mast cells
H3: nerve endings, CNS
prototype antagonist of H1 and H2 receptors
diphenydramine and ranitidine, respectively
1st generation antihistamine that is highly sedating
diphenhydramine
1st generation antihistamine that is least sedating
chlorpheniramine or cyclizine
2nd generation antihistamines
fexofenadine, loratadine, cetirizine
generation of antihistamine that has most CNS
1st generation because more lipid soluble
Major indication for H1 receptor antagonist
use in IgE mediated allergic reaction
antihistamine that can be used for anxiety and is not addictive
hydroxyzine (atarax)
H1 antagonist used in motion sickness
dimenhydrinate, meclizine, and other 1st generation
most common side effect of 1st generation antihistamines
sedation
lethal arrhythmias resulting from concurrent therapy with azole antifungals (metabolized by CYP3A4) and these antihistamines which inhibit 3A4 isoenzyme
terfenadine and astemizole (both removed from market)
H2 blocker that causes the most interactions with other drugs
cimetidine
clinical use for H2 blockers
acid reflux disease, duodenal ulcer and peptic ulcer disease
receptors for serotonin (5HT-1) are located
mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance
5-HT1d agonist used for migraine headaches
sumatriptan, naratriptan, and rizatriptan
triptan available in parenteral and nasal formulation
sumatriptan
H1 blocker that is also a serotonin antagonist
cyproheptadine
agents for reduction of postpartum bleeding
oxytocin, ergonovine, ergotamine
5HT-3 antagonist used in chemotherapeutic induced emesis
ondansetron, granisetron, dolasetron, alosetron
agents used in treatment of carcinoid tumor
ketanserin, cyproheptadine, phenoxybenzamine
5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
dolasetron
DOC for chemo induced nausea and vomiting
ondansetron
drug used in ergot alkaloids overdose, ischemia and pregnancy
nitroprusside
reason ergot alkaloids are contraindicated in pregnancy
uterine contraction- abortion
ergot alkaloid used as an illicit drug
LSD
SE of ergot alkaloids
hallucinations resembling psychosis
dopamine agonist used in hyperprolactinemia
bromocriptine
peptide causing increased capillary permeability and edema
bradykinin and histamine
mediator of tissue pain, edema, inactivated by ACE and may be a contributing factor to the development of angioedema
bradykinin
drug causing depletion of substance P (vasodilator)
capsaicin
prostaglandins that cause abortions
prostaglandin E1 (misoprostol), PGE2, and PGF2alpha