Pharm 16- Histamine, Serotonin, Ergot Alkaloids One Liners

Front 1

disease caused by excess ergot alkaloids

Back 1

St. Anthony's fire

Front 2

endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Back 2

autocoids

Front 3

syndrome of hypersecretion of gastric acid and usually caused by gastrinoma; associated with peptic ulceration and diarrhea

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Zollinger-Ellison syndrome

Front 4

drug that causes contraction of the uterus

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oxytocin

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distribution of histamine receptors H1, H2, and H3

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H1: smooth muscle
H2: stomach, heart, mast cells
H3: nerve endings, CNS

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prototype antagonist of H1 and H2 receptors

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diphenydramine and ranitidine, respectively

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1st generation antihistamine that is highly sedating

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diphenhydramine

Front 8

1st generation antihistamine that is least sedating

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chlorpheniramine or cyclizine

Front 9

2nd generation antihistamines

Back 9

fexofenadine, loratadine, cetirizine

Front 10

generation of antihistamine that has most CNS

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1st generation because more lipid soluble

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Major indication for H1 receptor antagonist

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use in IgE mediated allergic reaction

Front 12

antihistamine that can be used for anxiety and is not addictive

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hydroxyzine (atarax)

Front 13

H1 antagonist used in motion sickness

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dimenhydrinate, meclizine, and other 1st generation

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most common side effect of 1st generation antihistamines

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sedation

Front 15

lethal arrhythmias resulting from concurrent therapy with azole antifungals (metabolized by CYP3A4) and these antihistamines which inhibit 3A4 isoenzyme

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terfenadine and astemizole (both removed from market)

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H2 blocker that causes the most interactions with other drugs

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cimetidine

Front 17

clinical use for H2 blockers

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acid reflux disease, duodenal ulcer and peptic ulcer disease

Front 18

receptors for serotonin (5HT-1) are located

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mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

Front 19

5-HT1d agonist used for migraine headaches

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sumatriptan, naratriptan, and rizatriptan

Front 20

triptan available in parenteral and nasal formulation

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sumatriptan

Front 21

H1 blocker that is also a serotonin antagonist

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cyproheptadine

Front 22

agents for reduction of postpartum bleeding

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oxytocin, ergonovine, ergotamine

Front 23

5HT-3 antagonist used in chemotherapeutic induced emesis

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ondansetron, granisetron, dolasetron, alosetron

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agents used in treatment of carcinoid tumor

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ketanserin, cyproheptadine, phenoxybenzamine

Front 25

5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease

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dolasetron

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DOC for chemo induced nausea and vomiting

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ondansetron

Front 27

drug used in ergot alkaloids overdose, ischemia and pregnancy

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nitroprusside

Front 28

reason ergot alkaloids are contraindicated in pregnancy

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uterine contraction- abortion

Front 29

ergot alkaloid used as an illicit drug

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LSD

Front 30

SE of ergot alkaloids

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hallucinations resembling psychosis

Front 31

dopamine agonist used in hyperprolactinemia

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bromocriptine

Front 32

peptide causing increased capillary permeability and edema

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bradykinin and histamine

Front 33

mediator of tissue pain, edema, inactivated by ACE and may be a contributing factor to the development of angioedema

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bradykinin

Front 34

drug causing depletion of substance P (vasodilator)

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capsaicin

Front 35

prostaglandins that cause abortions

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prostaglandin E1 (misoprostol), PGE2, and PGF2alpha