Pharm 1 Test 2

Front 1

_____ Tolerance: associated with long-term administration of drugs such as morphine or heroin (causes MEC to increase)

Back 1

Pharmacodynamic

Front 2

______Tolerance: resulting from accelerated drug metabolism (does not affect)

Back 2

Metabolic

Front 3

Reduction in drug responsiveness brought on by repeated dosing over a short time

Back 3

Tachyphylaxis

Front 4

Certain ____ _____ are more effective in women than in men

Back 4

Opioid Analgesics

Front 5

____ causes greater QT interval prolongation in women than in men

Back 5

Quinidine

Front 6

Esters are local anesthetics inactivated/metabolized in the ____ by enzyme ____

Back 6

Blood
Esterases

Front 7

Amides are inactivated/metabolized by ____ ___ in the ____

Back 7

hepatic enzymes
liver

Front 8

Preanesthetic medication given to relieve anxiety and promote amnesia

Back 8

Benzodiazepines

Front 9

An alpha2-adrenergic agonist given preoperatively to relieve hypotension/pain/pre-op anxiety and cause sedation

Back 9

Clonidine

Front 10

Drugs given preoperatively to prevent bradycardia

Back 10

Anticholinergic drugs

Front 11

Antiemetic drug given postoperatively to suppress nausea and vomiting in patients undergoing chemotherapy

Back 11

Ondansetron

Front 12

Post-op drug given for relief of abdominal distention and urinary retention

Back 12

Muscarinic agonist

Front 13

Drug that causes hallucinations, disturbing dreams, and delieium

Back 13

Ketamine

Front 14

Premedication with ____ or ____ reduces the risk of an adverse reaction from ketamine

Back 14

Diazepam
midazolam

Front 15

Application of an ____ reduces the risk of bradycardia during surgery

Back 15

atropine

Front 16

Fentanyl is ____ the potency of morphine

Back 16

100x

Front 17

Morphine and other opioid agonists are thought to relieve pain by mimicking the actions of ___ ___ ___, primarily at mu receptors

Back 17

endogenous opioid peptides

Front 18

Anticholinergic drugs can exacerbate morphine-induced ___ and ___ ___

Back 18

constipation
urinary retention

Front 19

____ ____ can produce a syndrome characterized by excitation, delirium, hyperpyrexia, convulsions, and severe respiratory depression when taken with morphine

Back 19

MAO inhibitors

Front 20

Opioid antagonists are employed primarily to ____________

Back 20

treat opioid overdose

Front 21

What reverses morphine toxicity?

Back 21

Naloxone

Front 22

Fatal dysrhythmias, torsades de pointes, and respiratory depepression are adverse effects of _____

Back 22

methadone

Front 23

Gastric ulceration, renal impairment, bleeding, and MI and stroke are the main adverse effects of _____

Back 23

indomethacin

Front 24

WHat reverses APAP (acetaminophen) toxicity

Back 24

acetylcysteine

Front 25

Max daily dose of acetaminophen

Back 25

4g/day

Front 26

Like other NSAIDS, keterolac works by suppressing ____ ____

Back 26

prostaglandin synthesis

Front 27

Pain relief of ketorolac is equivalent to that of _____

Back 27

morphine and other opioids

Front 28

Minocycline works by inhibiting ___, an enzyme that promotes joint destruction

Back 28

collagenase

Front 29

The two main adverse effects of Minocycline

Back 29

Dizziness
Skin rash

Front 30

The usual maintenance dosage range for Methotrexate is:

Back 30

10-20 mg/wk

Front 31

Colchicine is used in treatment of ____

Back 31

gout

Front 32

_____ can inhibit hepatic drug-metabolizing enzymes, thereby delaying the inactivation of other drugs

Back 32

Allopurinol

Front 33

___, ___, and ____ should not be used with allopurinol ecause it could accumulate to toxic leels in the presence of allopurinol

Back 33

mercaptopurine
azathioprine
theophyl

Front 34

Usual maintenance dose for allopurinol

Back 34

100-300 mg/day

Front 35

Maintenance dose for febuxostat

Back 35

40-80 mg/day

Front 36

Maintenance dose for Probenecid

Back 36

500 mg BID

Front 37

Maintenance dose for Sulfinpyrazone

Back 37

200-800 mg/day