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73 Cards in this Set

  • Front
  • Back
ACh binds to:
nicotinic: CNS, PNS
muscarinic: CNS, PNS, SNS
nicotinic receptors are found:
skeletal muscle, neurons
muscarinic receptors are found:
smooth muscle, cardiac muscle, glands
S.L.U.D.G.E. stands for and what class
cholinergic, increases: salivation, lacrimation, urination, defacation, GI motility, emesis
Bethanechol (urecholine) class, category, and MOA
cholinergic, muscarinic agonist, activate only muscarinic
Bethanechol (urecholine)
indications
functional urinary reten tion via stimulation of bladder
Pilocarpine (Pilopine HS, Isopto Carpine, Pilocar) class, category, and MOA
cholinergic, muscarinic agonist, activate only muscarinic receptors
Pilocarpine (Pilopine HS, Isopto Carpine, Pilocar)indications
local open angle glaucoma (increases aqueous humor outflow)
mucarine class, category, MOA
poison, cholinergic, muscarinic agonist, activates only muscarinic receptors
Pyridostigmine (mestinon)class, category, MOA
cholinergic, AChE inhibitor, inhibit normal metabolic inactivation of ACh by inhibiting the enzyme AChE, activate both nicotinic and muscarinic
Neostgmine (prostigmin)class, category, MOA
cholinergic, AChE inhibitor, inhibit normal metabolic inactivation of ACh by inhibiting the enzyme AChE, activate both nicotinic and muscarinic
Pyridostigmine (mestinon)indication
glaucoma, reversal of post-op muscle paralysis due to neuromuscular blockers, myasthenia gravis
Neostgmine (prostigmin)indication
glaucoma, reversal of post-op muscle paralysis due to neuromuscular blockers, myasthenia gravis
Donepezil (Aricept) class, category, MOA
cholinergic, AChE inhibitor, inhibit normal metabolic inactivation of ACh by inhibiting the enzyme AChE, activate both nicotinic and muscarinic
Rivastigmine (Exelon) class, category, MOA
cholinergic, AChE inhibitor, inhibit normal metabolic inactivation of ACh by inhibiting the enzyme AChE, activate both nicotinic and muscarinic
Galantamine (Reminyl now Razadyne) class, category, MOA
cholinergic, AChE inhibitor, inhibit normal metabolic inactivation of ACh by inhibiting the enzyme AChE, activate both nicotinic and muscarinic
Donepezil (Aricept) indications
Alzheimers
Rivastigmine (Exelon) indications
Alzheimers
Galantamine (Reminyl is now Razadyne) indications
Alzheimers
Memantine (Namenda) indication and MOA
Alzheimers, decreases effects of glutamate (not an AChE I)
Organophosphate class, category, and indication
insecticide, POISON, cholinergic, long-acting (irreversible) AChE Inhibitor activates both muscarinic and nicotinic
Sarin
"nerve gas", POISON, cholinergic, long-acting (irreversible) AChE Inhibitor activates both muscarinic and nicotinic
Atropine class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh, - competitive
atropine indications
mydriasis, paralyzing accomadation, bradycardia, bronchospasm, ParaSNS and AChE ODs, drying salivary and mucous secretions, bower hypermotility
dry as a bone, red as a beet, blind as a bat, mad as a hatter, hot as a furnace all refer to and how is it treated:
atropine poisoning, physostigmine
Isopto Homatropine, Homatropine Ophthalmic, Homatropine Hydrobromide class, category, and MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Isopto Homatropine, Homatropine Ophthalmic, Homatropine Hydrobromide indications and CI
mydriasis, paralyzing accommodation (eye exams)
CI: untreated angle-closure glaucoma
atropine CI
glaucoma, athsma, BPH, urinary retention, tachycardia, GI obstruction, constipation
Benztropine (Congentin) class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Benztropine (Congentin) indication
Parkinson's
Ipratropium (Atrovent) class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Tiotropium (Spiriva)class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Trospium chloride (Sanctura)class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Tolterodine tartrate (Detrol, Detrol LA) class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Oxybutynin (Ditropan, Ditropan XL, Oxytrol) class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Darifenacin (Enablex)class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Solifenacin (Vesicare) class, category, MOA
cholinergic, anti-muscarinic/muscarinic antagoinist/muscarinic blocker, blocks muscarinic receptors for ACh
Ipratropium (Atrovent)indications
COPD, bronchospasm
Tiotropium (Spiriva)indications
COPD, bronchospasm
Trospium chloride (Sanctura)indications
overactive bladder, urge incontinence, bowel hypermobility
Tolterodine tartrate (Detrol) indications
overactive bladder, urge incontinence, bowel hypermobility
Oxybutynin (Ditropan, Ditropan XL, Oxytrol) indications
overactive bladder, urge incontinence, bowel hypermobility
Darifenacin (Enablex) indications
overactive bladder, urge incontinence, bowel hypermobility
Solifenacin (Vesicare) indications
overactive bladder, urge incontinence, bowel hypermobility
breaks down NE in presynaptic neuron
MAO
breaks down NE in post-synapse
COMT
alpha 1 effects
eye (mydriasis), small arterial constriction, decreased mucous secretion
alpha 2 effects
central; CV large arteriole constriction
beta 1 effects
heart, kidneys (increased renin release) and (decrease IOP)
beta 2 effects
lungs (bronchodilation)
combo alpha/beta effects
bladder and GI
Phenelzine (Nardil) category and indications
MAOI, not "true adrenergic agonists", depression
Tranylcypromine (Parnate) category and indications
MAOI, not "true adrenergic agonists", depression
Amitriptyline (Elavil) category, MOA and indications
TCAs (tricyclic antidepressants), NOT "true adrenergic agonist", decrease CNS reuptake of NE and 5HT1 which "restores" neurotransmitter imbalance, depression
Nortriptyline (Pamelor)category, MOA, and indication
TCAs (tricyclic antidepressants), NOT "true adrenergic agonist", decrease CNS reuptake of NE and 5HT1 which "restores" neurotransmitter imbalance, depression
Protriptyline (Vivactil)category, MOA, and indication
TCAs (tricyclic antidepressants), NOT "true adrenergic agonist", decrease CNS reuptake of NE and 5HT1 which "restores" neurotransmitter imbalance, depression
Imipramine (Tofranil) categoryk MOA, and indication
TCAs (tricyclic antidepressants), NOT "true adrenergic agonist", decrease CNS reuptake of NE and 5HT1 which "restores" neurotransmitter imbalance, depression
Epinephrine (Adrenaline) class, category, MOA, indications
adrenergic agonist, direct-acting sympathomimetic, direct agonist on all alpha and beta,anaphylaxis, cardiac arrest, severe bronchospasm, angioedema, vasoconstrictor for local anesthesis
Phenylephrine (Neosynephrine, Rynatuss, Deconsal) class, category, MOA
adrenergic agonist, direct-acting sympathomimetics, direct agonist on only alpha receptors (mydriasis, decrease mucous, baroreceptor reflex of decreased HR due to increase BP)
Phenylephrine (Neosynephrine, Rynatuss, Deconsal) indications
nasal decongestant, hypotension
Brimonidine (Alphagan P), Apraclonidine (lopidine) class, category, MOA and
adrenergic agonist, direct-acting sympathomimetics, direct agonist on alpha 2 receptors (true MOA unknown)
Brimonidine (Alphagan P), Apraclonidine (lopidine) indication
glaucoma
Dobutamine (Dobutrex)class, category, MOA
adrenergic agonist, direct-acting sympathomimetics, selective beta 1 agonist
Dopamine (Intropin)class, category, MOA
adrenergic agonist, direct-acting sympathomimetics, selective beta 1 agonist
Dobutamine (Dobutrex)indication
Acutely decompensating heart failure, 1st line in cardiogenic shock due to acute MI
Dopamine (Intropin) indication
Acutely decompensating heart failure, 1st line in cardiogenic shock due to acute MI
short acting Albuterol (Proventil) and long acting Salmeterol (Serevent Diskus) class, category, MOA, and indication
adrenergic agonist, direct-acting sympathomimetric, selective beta 2, asthma and COPD
Pseudoepidrine (Sudafed, Claritin, Zyrtec) and Phenylpropanolamine (PPA) class, category, MOA, and indication
adrenergic agonist, mixed-acting sympathomimetics, directly stimulates alpha and beta receptors and NE release and used as mucous membrane decongestant and anorexigenic agent
Amphetamines, Phentermine (Adipex-P), Adderall, Dexedrine, Dextrostate, Adderall, Analogs: (methylphenidate and dexmethylphenidate)
class, category, MOA, indications
adrenergic agonists, indirect-acting sympathomimetics, act only by releasing NE from nerve endings, used for anorexigenic agent, narcolepsy, ADHD, CNS stimulant (abuse)
concerta, focalyn, metadate, ritalin, methylin, phendimetrazine (Bontril), benzphetamine (Didrex), Diethylpropion (Tenuate)
class, category, MOA, indications
adrenergic agonists, indirect-acting sympathomimetics, act only by releasing NE from nerve endings, used for anorexigenic agent, narcolepsy, ADHD, CNS stimulant (abuse)
this is found in "party foods and beverages" and increases the effects of indirect-acting sympathomimetics
tyramine
amphetamines are what schedule of drugs
schedule II
Isoproterenol class, category, MOA and indication
direct-acting sympathomimetics and is nonselective beta agonist and is rarely used clinically