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15 Cards in this Set
- Front
- Back
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Which Receptors increase TPR, and which receptors are responsible for the resulting reflex bradycardia?
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a1, M2
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Which Receptors decrease TPR, and which receptors are responsible for the resulting reflex tachycardia?
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B2, B1
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Which type of drug can you give to cause mydriasis with no cycloplegia?
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a1 agonist
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What kind of receptors are M1 and M3 and how do they initiate signaling?
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Gq receptors, increase Phospholipase C, Ip3, Dag, Ca+2
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What kind of receptors are Nm and Nn and how do they initiate signaling?
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Nicotinic receptors, activate and open Na/K channels. No 2nd messengers
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What kind of receptors are M2 and how do they have their effect on signaling?
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Gi, decreases adenyl cyclase and cAMP.
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Ach: what receptors does it activate, what is the clinical use?
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M and N, no clinical use b.c. metabolized too quickly by AchE
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Bethanechol: what receptors does it activate, what is the clinical use, administration
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M, postop/neurogenic ileus, urinary retention, slows down heart. Administered orally or subcutaneous. Not readily broken down by AchE.
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Carbachol: what receptors does it activate, what is the clinical use, administration
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M, given on eye conjunctiva, not readily broken down by AchE
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Adverse reactions of cholinergic agonists given on conjunctiva (Ach, Carbachol)
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iritis, detachment of retina, cataract, far vision/dark vision difficulty, reddening stinging or burning of conjunctiva
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When Cholinergic agonists are given systematically i.e. Bethanechol what are the adverse effects?
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nausea vomiting abd. pain diarrhea, bronchospasm and cough, increased gland activity, flushing and warmth of skin, urinary emergency, hypotension
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Pilocarpine: what is it and how used?
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natural alkaloid, effects like cholinergic agonist, used in xerostomia and for open angle glaucoma
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Name reversible Cholinesterase inhibitors
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Neostigmine Physostigmine (carbamates);edrophonium, donepezil (long lasting)
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Irreversible AchE inhibitors
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Organophosphates
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Reversible AchE inhibitors timeframe of action
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Edrophonium rapid, carbamates effect last 1-6 hours,
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