Phar753 Exam 1 Upper Gi

Front 1

Prostaglandins role 3 things

Back 1

1. turn off cAMP pathway to turn off proton pump

2. turn on EP3 for mucous and bicarbonate (cytoprotective)

3. Vasodilation to flush out toxins

Front 2

Somatostatin analog drug is

Back 2

Octreotide

Front 3

effects of octreotide

Back 3

decrease gastrin release, decrease gastric motility. For Zollinger Ellison syndrome and severe diarrhea. for supressing growth hormone and for actromegaly.

Front 4

Pirenzepine MOA

Back 4

M1 selective antagonist used in other countries.

In US we use hyoscamine.

Front 5

Cimetidine MOA

Back 5

H2 blocker decreasese both basal and H ion secretion

Front 6

H2 blockers are best for

Back 6

nocturnal dyspepsia

Front 7

H2 blockers side effects with cimetidine

Back 7

effeccts of CYP 3a4, 2d6, 1a2 and aldehyde oxidase. Anti androgenic effects like gynecomastia.

CONFUSION and CNS HA, fatigue. Needs dosing adjustments if bad kidneys.

Front 8

Omeprazole inhibits what enzymes

Back 8

2C19, 3A4

Front 9

omeprazole SE's

Back 9

diarrhea,nasuea, HA, rash

Front 10

Omeprazole affects absorption of what drugs

Back 10

antifungals because they like acidic environment.

Clopidogrel

Front 11

Omeprazole used chronically may decrease the

Back 11

absorption of iron calcium magnesium.

Front 12

Onset of omeprazole

Back 12

full efficacy delayed 3-4 days. give 30 to 60 min before food. Not with food. due to 1/2 bioavail.

Front 13

Risks with PPI and H2's

Back 13

-Reflex increased gastrin

-Increased infections of

C Diff with long term use

Pneumonia with short term use, not long term.

Front 14

Risk with PPI only, and how many days not to exceed

Back 14

Hip fracture; 60 days.

Front 15

Misoprostol MOA

Back 15

Prostaglandin pg 1 analog. Action to inhibit cAMP dependent pump activation, increase secretion of mucous and bicarbonate.

Front 16

Misoprostol indication

Back 16

NSAID induced dyspepsia or ulceration

Front 17

Misoprostol SE's

Back 17

significant diarrhea and abdominal cramping

Front 18

How sucralfate works

Back 18

When in presence of pH less than 4, turns into a gel. Will bind to exposed tissues and forms a protective barrier. But doesn't stay long. So need to QID.

Front 19

sucralfate is ideal for treating

Back 19

duodenal ulcers

Front 20

Sucralfate main SE:

Back 20

constipation

Front 21

If renally compromised, sucralfate can cause

Back 21

Aluminum toxicity.

Front 22

Bismuth how it works

Back 22

reacts with exposed tissue and creates a barrier and ALSO increase proudction of mucous and bicarbonate. ALSO antibacterial action.

Front 23

Bismuth SE's

Back 23

black hairy tongue. Dark stools. Bismuth toxicity with renally impaired.

Front 24

Primary contributor to peptic ulcer disease

Back 24

H Pylori

Front 25

H Pylori is a bacterium..

Back 25

gram negative athat produce enzymes and bicarbonate that protects it from environment. The inflammatory response is what makes for gastric ulcerations. Some people generate greater inflammatory.