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122 Cards in this Set

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Sumatriptan
U: Migraines

M: Agonists of 5-HT1D & 1B receptors

SE: Vasoconstiction of carotid and cranial
circulation

v cAMP & adenyl cyclase
Erogotamine
C: Ergot Amines
U: migraines
M: agonist & p. agonist of 5HT1D & 1A receptors
SE: vasoconstriction of carotid & cranial circulation

Decrease cAMP & adenyl cyclase
Alosetron
C:
U: Treat IBS
M: 5-HT3 antagonist
SE: diarrhea
Tegaserod
C:
U: IBS w/ Diarrhea
M: partial 5-HT4 agonist

-only for women
Odansteron
C:
U: Treat Nasea & Vomitting
M: 5-HT3 agonist
Strychnin
C: Toxin
U: Anxiolytic/Sedative/Hypnotic
M:comp anatagonist of glycine
SE:
Tetanus toxin
C: Toxin
U:
M: inhibits release of glycine - leads to excitation (full contraction of all voluntary muscles)
SE:
Thiopental
C:Barbituate

U:Sedative/Hypnotic

-GEN SEIZURES
-Esp for ANESTHESIA = *C-SECTIONS
-v O2 REQUIREMENT OF BRAIN

M:potentiates GABA; up duration of Cl- channel

SE: dependence, drowsiness, impaired congnition, confusion, depressed motor skills

v SNS, no chance in vasc r, resp depression, broncho/larygospasm, v mucociliary clearance

INDUCTION OF CYP450

SOME HISTAMINE RELEASE = hypotention

CONTRA:
pericardial tamponade
hypovolemia
CHF
Ischemic heart dz
Phenobarbital
C:Barbituate
U:Sedative/Hypnotic/

-General seizures
-Esp for EtOH dependence

M:potentiates GABA; up duration of Cl- channel
SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills

v SNS, no chance in vasc r, resp depression, broncho/larygospasm, v mucociliary clearance

INDUCTION OF CYP450
Disulfiram
C:
U:treat alcohol abuse
M:block ADH
CONTRA: pregnancy, liver dz
Contra for all barbituates
-porphyria
-upper airway obstruction
Etomidate
C: Barbituate
U: esp used for pain & anticonvulsant

Special appeal = heart stability

SE: v cortisol syn
clonus on onset(major twiches)
v activity of A & B hydroxylases
Chlordiazepoxide
C:Benzodiazepine
U:Sedative/Hypnotic

LONG DURATION

M:potentiates GABA; up duration of Cl- channel

SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills
Diazepam
C: Benzodiazepine
U:Sedative/Hypnotic

ANTI-SPASM
STATUS EPILIPTICUS

M:potentiates GABA; up duration of Cl- channel
SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills

INSOLUBLE: SUPPLIED IN EMULSION
Lorazepam
C: Benzodiazepine
U:Sedative/Hypnotic

SHORT DURATION
STATUS EPILIPTICUS (1st line)
M:potentiates GABA; up duration of Cl- channel
SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills
Midazolam
C:Benzodiazepine
U:Sedative/Hypnotic

ANESTHESIA
PREFERRED IN OR b/c METABOLITE HAS NO EFFECTS
M:potentiates GABA; up duration of Cl- channel
SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills
Oxazepam
C: Benzodiazepine
U:Sedative/Hypnotic

VERY SHORT DURATION (faster than lorazapam)
STATUS EPILIPTICUS (1st line)
M:potentiates GABA; up duration of Cl- channel
SE:dependence, drowsiness, impaired congnition, confusion, depressed motor skills

VERY ACTIVE METABOLITE
For patients with liver injury, benzos or barbituates?
Benzos, b/c barbituates induce CYP450 system
Erogonovine, Methylergonovine
C: Ergot Alkyloids
U: poweful smooth muscle contractor

Treat Post-partum hemorrhage when oxytocin not effective

M:agonist of A-adrenergic receptors & 5-HT2 receptors
SE:
Methysergide
C: Ergot Alkyloids
U: poweful smooth muscle contractor

PROPHYLAXIS of MIGRAINE
M:Antagonist of 5-HT2A & 2C
SE:
Ketamine
C:
U:PRE-EMPTIVE ANALGESIA = minimizes need for post-op analgesia

v "wind up" effect (bruise doesnt hurt hours later)
M:
SE: excitement, hallucinations, flashbacks
Baclofen
C:
U:Anti-spasm (CNS)
M:acts as GABA agonist on afferent part of reflex arc

v release of excitatory NT
SE:
Flumazenil
C:Anxiogenic

U: Treat benzo OD

M: Benzo receptor antagonist (Cl- channel)

SE: Anxiety

-physostigmine (cholinesterase inhibitor) usually used before
Gamma-hydroxybutyrate (GHB)
C: Anesthetic (found naturally in CNS - basal ganglia)

U:None medically - raves and date rape

fast onset and short duration

M:binds GABA-B receptors for profound CNS depression and short-term amnesia

inhibits NE release in hypothalamus

inhibit DA release @ low doses but not @ high

SE: dependence, very psychotic withdrawal

DIFFERENCE FROM OPIATES = 1) causes intubation resistance 2) no respiratory depression

withdrawal much more difficult than alcohol
Codeine
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Fentanyl
C: Opiod

U: Analgesic

PATCH - SLOW ONSET, LONG DURATION

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Heroin
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Hydrocodone
C: Opiod

U: Analgesic

HIGHLY ABUSED

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Hydromorphone
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Morphine
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Methadone
C: Opiod

U: Analgesic

USED TO TREAT OPIATE WITHDRAWALS

OFTEN ABUSED, PALLIATIVE

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Oxycontin
C: Opiod

U: Analgesic

LONG DURATION

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Oxymorphone
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Propoxyphene
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Tramadol
C: Opiod

U: Analgesic

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Suboxone
Combined Buprenorphine (partial opiate agonist) and Naloxone (opiate antagonist)
Buprenorphine
C: partial opiate agonist

U: Analgesic (kidney stones)

OPIATE WITHDRAWAL

MU, KAPPA, DELTA receptor agonist to block nociception

SE:dependence, constipation, nausea, vomiting, cough suppression, sedation, reduced urinary flow (and UTI)

OD: respiratory depression, coma, MIOSIS
Naloxone
C: Opiate Antagonist

U: Acute Opiate OD

very fast onset

M: MU, KAPPA, DELTA receptor antagonist to block nociception

SE: May precipitate withdrawal, overshoot tachypnea

CONTRA: LIVER DISEASE
Naltrexone
C: Opiate Antagonist

U: Acute Opiate OD

very fast onset

M: MU, KAPPA, DELTA receptor agonist to block nociception

SE: May precipitate withdrawal, overshoot tachypnea
Clonidine
A-2 receptor agonist

OPIATE WITHDRAWAL RELIEF

SE: dry mouth, sedation, sexual dysfxn
4-Aminopyridine
C: NMJ Block Reverser

U: Reversal of paralysis

M: Blocks K+ channels in presynaptic nerve --> allows Ca2+ channels to remain open --> increased release of ACh
Botulinum Toxin
C: Spamolytic

U: paralysis; removal of wrinkles

M: inhibits ACh vesicle fusion and release via cleavage of fusion protein
Hemocholinium
C: NMJ Blocker

U: Tx for muscle spasms

M: Blocks reuptake of choline in presynapse --> depletion of ACh stores
Succinylcholine (SC)
C: Depolarizing NM blocker

U: Muscle relaxation and paralysis

FAST ONSET, ShORT DURATION

M: Phase 1: slowly and reversibly binds to prejxnla nicotinic receptor --> prolonged depolarization --> inactivation of time-dependent Na channels (V-dependent still activated)

Also effector on muscarinic receptors but they recover more quickly than nicotinic

Phase 2: desensitization of nicotinic receptor to ACh

SE (esp w/ 2nd dose): malignant hyperthermia, K+ release (^ arrhythmias by keeping IMMATURE nicotinic receptors open longer) (esp burn/trauma pts), hypotension, increased IO pressue, gastic pressue, muscle pain

CONTRA: newborns, burn victims, kidney problems
Aminogycosides
^ NM block

(i.e. in MG effects)

-channel blocker
Dibucaine
assesses plasma cholinesterase activity
Magnesium
^ NM block

used in PRECLAMPSIA
Propoful
IV anesthetic

LEAST POSTOP NASEA & VOMITTING
Which 2 Non-depolarizing NM Blockers have minimal heart problems?
Vecuronium & Cisatracurium
St John's Wort
C: Herbal OTC

U: Depression

SE: INDUCES CYP450 (^ drug interaction)
Anticholinergics in Parkinsons Treatment are used in what population?
young patients

causes dementia in old patients
Amantidine special use?
Parkinson's

Antiviral agent that also blocks glutamate receptors
Curare (Detubocurarine)
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: histamine release --> flushing, edema, erythema, HYPOTENSION, tachycardia
Mivacurium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: histamine release --> flushing, edema, erythema, HYPOTENSION, tachycardia
Atracurium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: histamine release --> flushing, edema, erythema, HYPOTENSION, tachycardia

its metabolite, Laudanosine, can cross BBB and cause seizures

^ MAC
Pancuronium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: histamine release --> flushing, edema, erythema, HYPOTENSION, tachycardia

Also blocks vagal tone, produces achycardia & ^ NE release

CONTRA: patient with coronary heart dz
Vecuronium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: VERY LITTLE histamine release (less heart problems)--> flushing, edema, erythema, HYPOTENSION, tachycardia

CONTRA: pts w/ renal failure
Cisatracurium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: VERY LITTLE histamine release (less heart problems)--> flushing, edema, erythema, HYPOTENSION, tachycardia

derivative of atracurium (less laudanosine, therefore less toxic)
Rocuronium
C: Non-depolarizing NM Blocker

U: Muscle relaxation and paralysis

M: compeitive nicotinic ACh receptor antagonist. Prevents depolarization of muscle cell

SE: histamine release --> flushing, edema, erythema, HYPOTENSION, tachycardia
-curonium & -curnium
non-depolarizing NM blockers (i.e. curare)
Dantrolene
C: central muscle relaxant

U: Anti-spasm for muscles

Baclofen = antispasm for CNS

M: inhibits Ca2+ release from SR of muscle cells, preventing contraction
Desipramine
C: TCA (secondary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

PARTICULARLY NE!
SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Nortiptyline
C: TCA (secondary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Protriptyline
C: TCA (secondary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Clomipramine
C: TCA (tertiary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

PARTICULARLY 5-HT

SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Amitriptyline
C: TCA (tertiary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

5-HT = NE

SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Imipramine
C: TCA (tertiary)

U: depression

M: inhibition of 5-HT and NE reuptake transporters

SE: heart block, tachycardia, ANTICHOLINERGIC EFFECTS, sedatoin, blurred vision, constipation, weight gain, orthostatic HT

OD: coma w/shock, resp depression, delirium, HT, arrhythmia
Phenelzine
C: MAO-A Inhibitor

IRREVERSIBLE

U: depression

M: inhibi MAO from degrading unvesicled monoamines (5-HT & NE) intracellularly

SE: hepatotoxicity, TYRAMINE TOXICITY (HT crisis)

OD: agistation, delirium, mania; seizures, hyperthermia, HT
Tranylcypromine
C: MAO-A Inhibitor

REVERSIBLE

U: depression

M: inhibi MAO from degrading unvesicled monoamines (5-HT & NE) intracellularly

SE: hepatotoxicity, TYRAMINE TOXICITY (HT crisis)

OD: agistation, delirium, mania; seizures, hyperthermia, HT
Fluoxetine
PROZAC

C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: Nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450
Sertraline
C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: DIARRHEA, nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450
Paroxetine
C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: CONSTIPATION, nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450

WITHDRAWAL SYNDROME
Fluvoxamine
C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: Nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450
Citalopram
CELEXA

C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: Nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450
Escitalopram
LEXPRO

S enantiomer of Citalopram

MORE POTENT: 1-2 wks instead of 3-4

C: SSRI

U: depression

M: inhibit 5-HT reuptake transporters (may bind NE transporters @ high dose)

SE: Nausea, insomnia, anxiety, nervousness, SEROTONIN SYN; hyperthermia, muscle rigidity, INHIBITS CYP450
Trazodone
C: Atypical Antidepressant

U: depression

M; inhibits 5-HT reuptake adn blocks postsynaptic 5-HT2 (enhanced 5-HT1 mediated transmission)

SE: SEDATION (many use for sleep instead), dizziness, nausea

less liver toxicity
Nefazodone
C: Atypical Antidepressant

U: depression

M: inhibits 5-HT reuptake adn blocks postsynaptic 5-HT2 (enhanced 5-HT1 mediated transmission)

SE: SEDATION, dizziness, nausea

LIVER TOXICITY --> puled form market
Venlafaxine
C: Atypical Antidepressant

U: depression

M: inhibits 5-HT reuptke transporters @ low doses (like SSRI...but does NOT inhibit CYP450)

inhibits NE transporter @ high doses (like TCA)

SE: nausea, agitation, sexual dysfxn, serotonin syn
Mirtazapine
C: Atypical Antidepressant

U: depression

SE: SEDATION
M: blocks postsynaptic 5-HT2 & A2 receptors
Buproprion
C: Atypical Antidepressant

U: depression

M: DA & NE reuptake inhibtion

SE: insomnia, HA, nervousness, constipation, dry moth, SEIZURES, psychosis; INHIBITS CYP450

NARROW TI

CONTRA: anorexia, bulemia, epilepsy
Carbamazepine
C: Anti-Seizure

U: Partial seizures, sometimes
generalized seizures

Bipolar Disorder

M: Voltage gated Na+ channel blocker

SE: diplopia, ataxia, rash, LEUKOPENIA, INDUCES CYP450

SPEEDS ITS OWN METABOLISM (have to increase dose)
Oxcarbazepine
Designed for those allergic to carbamzepine

SE: HYPONATREMIA
Lamotrigine
C: Anti-Seizure

U: Partial seizures

Bipolar Disorder

M: Voltage gated Na+ channel blocker

SE: rash, STEVENS-JOHNSONS SYNDROME, somnolence

if taken during 1st trimester, ^ chance of cleft lip or cleft palate
Phenytoin
C: Anti-Seizure

ADJUNCTIVE THERAPY

U: Partial seizures

Generalized seizures

STATUS EPILIPTUCUS (2nd line, given after benzo)

M: Voltage gated Na+ channel blocker

SE: Nystagmus, diplopia, ataxia, TERATOGENIC, STEVENS JOHNSONS SYN, hirsutism, GINGIVAL HYPERPLASIA, folic acid depletion, INDUCES CYP450

-need good peripheral IV or else might lose limb

-stop enteral feeds
Topiramate
C: Anti-Seizure

U: Partial seizures

TONIC CLONIC SEIZURES (generalized)

also treats LENNOX-GASTAUT SYN


M: Voltage gated Na+ channel blocker

Also blocks glutamate AMPA receptor; ^ GABA receptor activity

SE: slowed speech, kidney stones, aesthesia, blurred vision 2ary to glaucoma, TERATOGENIC
Zonisamide
C: Anti-Seizure

U: Partial seizures

M: Voltage gated Ca2+ channel blocker

SE: Irritability, anorexia
What are good drugs for generalized seizures?
1)Barbituates

2)Felbamate

3)Valproate

4)Phenyltoin
Ethosuximide
C: Anti-Seizure

U: ABSENCE SEIZURES (1st line!)

M: Voltage gated Ca2+ channel blocker

SE: dose related GI, hyperactivity, dizziness, headache
Valproate
C: Anti-Seizure

U: GENERALIZED SEIZURES

DOC for MYOCLONIC SEIZURES

also partial and absence seizures (2nd line)

M: Voltage gated Ca2+ AND Na+ channel blocker

SE: lethargy, tremore, HEPATOTOXICITY, weight gain, alopecia

"Fat,slow Val started losing his hair"..."and now has liver disease (hepatoxicity)"
Drugs for Status epilepticus tx?
1) Bezodiazepines:

LORAZEPAM
DIAZEPAM

2)Phenytoin

3)Phenobarbital (esp for INFANTS)
Viagabatrin
C: Anti-Seizure

U: Partial seizures

M: GABA aminotransferase blocker

SE: visual problems
Gabapentin
C: Anti-Seizure

U: Partial seizures

M: GABA aminotransferase blocker

SE: leukopenia
Tiagabine
C: Anti-Seizure

U: Partial seizures

M: GABA reuptake transporter blocker

SE: dizziness, somnolence
Selegiline
C: MAO-B Inhibitor

U: PARKINSONS

M: Inhibit MAO from degrade DA

SE: Tyramine txoicity

CONTRA: cheese, wine --> hypertensive episode
Rasagiline
C: MAO-B Inhibitor

U: PARKINSONS

M: Inhibit MAO from degrade DA

SE: Tyramine txoicity

CONTRA: cheese, wine --> hypertensive episode
Tolcapone
Parkinsons

COMT Inhibitor

-more LIVER FAILURE (no longer used)
Entacapone
Parkinsons

COMT Inhibitor

-less LIVER FAILURE
Levodopa
Parkinsons

SE: Vomiting, may exacerbate sym in physchotic patients b/c ^ DA
Carbidopa
Parkinsons

Dopa decarboxylase Inhibitor
Who are anticholinergic Parkinson's treatments reserved for?
Young patients (old patients = dementia)
What antiviral drug may be used to treat Parkinson's?
Amantidine

- also blocks glutamate receptors
Sinemet is a combination of what 2 drugs? Use?
Levodopa & Carbidopa

-prevents nasea
Stalevo
3x Combo Parkinson's Drug

Levodopa, Carbidopa & COMT Inhibitor
Bromocriptine
Ergoline DA agonist - DIFFUSE (all receptors)

Parkinson's & Prolactic excess

SE: fibrosis, heart valve problems, hallucinations, sedation, compulsive behavior
Pergolide
Ergoline DA agonist - DIFFUSE (all receptors)

Parkinson's & Prolactic excess

SE: fibrosis, heart valve problems, hallucinations, sedation, compulsive behavior
Pramipexole
Non-Ergoline DA agonist - D2 SPECIFIC

Parkinson's & Prolactic excess

SE: Hallucinations, sedation, compulsive behavior
Ropinirole
Non-Ergoline DA agonist - D2 SPECIFIC

Parkinson's & Prolactic excess

SE: Hallucinations, sedation, compulsive behavior
What other 2 additional benefits do DA agonists provide in Parkinson's Tx?
1) v Dyskinesia

2) Neuroprotective
What is Lithiums Mech?
Inhibits a-1 adrenergic receptor by INHIBITING PHOSPHATASE that creates inositol from IP3

Also ANTITHYROID for hyperthyroidism

-this prevents PIP2 from being regenerated

-also INHIBITS RELEASE of T3 and T4 from thyroid
Chlorpromazine
1st Generation Antipsychotic
-Temperature dysregulation
Perphenazine
1st Generation Antipsychotic
Trifluoperazine
1st Generation Antipsychotic
Thiothixene
1st Generation Antipsychotic
Haloperidol
1st Generation Antipsychotic
Clozapine

SE?
2nd Generation Antipsychotic

AGRANULOCYTOSIS

-therefore not used much
Risperidone
2nd Generation Antipsychotic
Olanzepine
2nd Generation Antipsychotic
Queiapine
2nd Generation Antipsychotic
Ziprasidone
2nd Generation Antipsychotic

METABOLIED BY ALDEHYDE OXIDASE NOT CY450 like the rest!
Aripiprazole
2nd Generation Antipsychotic
Symbax
Bipolar Combo Drug

Olanzepine (2nd Generation Antipsychotic) & Fluoxetine (Prozac)

SE: somnolence, weight gain
What would you use for antipsychotic drug overdose?
1)Bromocriptine (lecture)

2)Dantrolene (Book)