Ph2010.04.23- Prin Clinical Toxicology

Front 1

5 factors affecting the dose-response relationship of a toxin

Back 1

1. route
2. biotransformation
3. health/nutritional status
4. age
5. genetics

Front 2

Basic mechanism of chemical carcinogenesis

Back 2

--bind DNA
--misreading when making daughter cells
--mutations passed down

Front 3

Describe category A teratogens

Back 3

no teratogenicity in animals & humans

Front 4

Describe category B teratogens

Back 4

Either:
1. no teratogenicity in animals, no data for humans
2. teratogenicity in animals, non-teratogenic in humans

Front 5

Describe category C teratogens

Back 5

either:
1. teratogenic in animals, no human data
2. no data for animals or humans

*give when benefit justifies risk

Front 6

Describe category D teratogens

Back 6

human risk present, benefits to mom may be acceptable in life-threatening/serious ds

Front 7

Describe category X teratogens

Back 7

risk clearly outweighs possible benefit

contraindicated in preg women/those who might become preg

Front 8

Ach-ase (cholinergic) syndromes:
1. Common cause
2. 5 Muscarinic sxs
3. 3 Nicotinic sxs
4. 2 CNS sxs

Back 8

1. insecticides inhibit Ach-ase (organophosphate/carbamate)

2. sweating, miosis/blurred vision, wheezing, GI cramps/diarrhea, bradycardia/hypoTN

3. fasiculations/cramps, weakness/paralysis, respiratory compromise

4. anxiety, seizures

Front 9

Anticholinergic syndrome:
1. 5 causative agents
2. 5 Peripheral effects
3. 3 Central effects

Back 9

1. atropin, scopolamine, TCADs, antihistamines, jimson weeds

2. dry mouth, tachycardia, dry skin, flushing, dilated pupils

3. lethargy, seizures, confusion

Front 10

List 2 Hb-opathies and their causes

Back 10

1. carboxyhemoglobinemia from CO

2. methemoglobinemia from sulfonamides

Front 11

triad of narcotic overdose

Back 11

1. pinpoint pupils
2. respiratory depression
3. hypoTN

Front 12

4 methods of removal of toxin from GI tract

Back 12

1. vomiting
2. gastric lavage
3. activated charcoal
4. whole bowel irrigation