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13 Cards in this Set
- Front
- Back
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Chloroquine:
1. what types of malaria txs (2)? 2. active against what phase of Plasmodium? 3. MOA 4. not used against which spp? |
1. prophylaxis & active infection
2. erythrocytic 3. causes buildup of free heme w/in Plasmodium 4. P. falciparum, except in C. America, Caribbean, Mid East |
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Mefloquine:
1. what types of malaria txs (2)? 2. DOC in what situation? 3. AEs (4) |
1. prophylaxis & active infection
2. prophylaxis in areas of chloroquine resistance 3. sleep probs, N/V, neuropsych probs, cardiac arrhythmias |
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4 alternatives to mefloquine prophylaxis:
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1. atovaquone + proguanil
2. proguanil + sulfadoxin 3. pyrimethamine + sulfadoxin 4. doxycycline |
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Quinine/Quinidine:
1. DOC for what malaria? 2. Purpose of combining w/ 2nd agent 3. general term for AE (5 pts) 4. Pregnancy use? |
1. tx of severe dz w/ chloroquine resistent falciparum
2. decrease duration & toxicity of quinine 3. cinchonism (headache, nausea, vis disturbs, dizzy, tinnitus) 4. can be used |
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Primaquine:
1. Used in what malaria pt group? 2. Pt group at risk of anemia? |
1. those w/ documented P. vivax infection (can kill P. vivax in liver)
2. those w/ G6PDH def |
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Artemisinin:
1. MOA against Plasmodium 2. Why combine w/ 2nd agent? |
1. creates free radicals w/in Plasmodium
2. Artemisinin has a short half life and be gone before all Plasmodia are killed |
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1 drug against tissue amoebas and 1 against lumen amoebas
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tissue: metronidazole
lumen: iodoquinol |
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Drug for tx of Leishmaniasis
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Na stibogluconate
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Drug for tx of Toxoplasmosis
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pyrimethamine
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2 common drugs for Tx of helminths
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albendazole
praziquantal |
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2 drugs for tx of African trypanosomes
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blood: suramin
CNS: melarsoprol |
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Drug for tx of Chagas' dz
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nifurtimox
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Drug for tx of Giardia
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metronidazole
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