Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

19 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
What is pKa equal to in terms of Ka (dissociation constant)
What is a good buffer?
buffers are most effective in controlling pH and binding H+ if the pH is near the pKa of their ionizing group
Know how to find the best pH (concentration of H+) on a titration curve graph… pKa is the center of the curve, where 50% of the buffer species has a proton attached.
What are two buffers seen in the physiology?
bicarbonate and ammonia
pH 7.4, with a corresponding [H+] = 40nm/l, is normal for blood plasma. What changes in [H+] and corresponding pH are life threatening?
alkalosis: 20nm/l = 7.7… and acidosis: 100nm/l = 7.0… not 7.1-7.3 are clinically significant [50-80nm/l]
Is Hb a buffer?
yes, it's temporary reservoir for H+, but only inside the RBC
Which direction does carbonic anhydrase work?
both direction… formation of H2CO3 and formation of H20 +CO2
What does the band 3 protein do?
it is an anion exchanger Cl- for HC03
where is bicarbonate produced?
How are the lung important in maintaining pH balance in the body?
H+ are excreted as the H in H2O
Where do you find carbonic anhydrase?
RBCs and Kidney
Give the Henderson-Hasselbalch equation, only to show the effects of plasma HCO3- and pCO2 concentrations on pH.
pH = 6.1 + log [HCO3-]÷(0.0301 X pCO20… such that a rise in HCO3- will cause an increase in pH and an increase in pCO2 will cause a drop…or any overall increase in the quotient will cause a rise in pH
What does the liver do in resonsponse to low pH?
reabsorb HCO3
What two general catagories cause repiratory acidosis?
(a) U:An increase in blood pCO2, ORIGINS: COPD, chronic lung disease, lung removal, sedation, hypoventilation. (b) U: A decrease in [HCO3], ORIGINS: excess production of organic acids, loss of HCO3 via DIARRHEA.
What two general catagories causes respiratory alkalosis?
(a) U: A decrease in blood [CO2], ORIGINS: hyperventilation (light-headedness follows). (b) U: increase in blood bicarbonate, ORIGINS: vomiting gastric fluids, consuming large amounts of antacides, dehydration (reduced pressure for renal filtration)
How do the kidneys compensate for alkalosis? For (a) decrease in pCO2 and (b) increase in blood [HCO3]
(a) decrease in renal bicarb resorption and an increase in renal K+ secretion into the renal tubule (b) decrease in respiration to increase plasma [CO2]
How do the kidneys compensate for acidosis? For (a) increase in blood CO2, (b) decrease in plasma [HCO3]
(a) decrease in renal bicarb and increase in renal H+ secretion into the renal tubules. (b) increase respiration to clear CO2 from plasma.
Based on lab tests, how can you diagnose organic acidosis?
When the anion gap grows (normal is about 10
What is the biochemical basis for diabetic ketoacidosis (or alcohol consumption)?
In order to maintain an anion balance the cells will transport out a protein, i.e., ketoacid, but you can't pass it through the membrane with a charge, so a cation, i.e., K+ or Na+ will attach to the anion. However when the cell runs low on K+ it will steal a proton from a protein... once released from the cell it lowers the plasma pH.