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19 Cards in this Set

  • Front
  • Back
What is ACh's action at a M1 receptor? What blocks this action?
1. Decreaseds K conductance
2. Increases DAG and IP3 activity
3. Pirenzepine and atropine
What is ACh's action at a M2 receptor? What blocks this action?
1. Increases K conductance
2. Decreases DAG and IP3 activity
3. Atropine
What is ACh's action at a nicotinic receptor?
1. Increases cation conductance
What is dopamine's action at D1 receptors? What blocks this action?
1. Increases cAMP (inihibitory)
2. Phenothiazines
What is dopamine's action at D2 receptors? What blocks this action?
1. Presynaptic - Decreases Ca conductance
2. Post-synaptic - Increases K conductance
3. Phenothiazines and Haloperidol
What is norepinephrine's action at Alpha-1 receptors? What blocks this action?
1. Decreases K conductance
2. Increases DAG and IP3 activity
3. Prazosin
What is norepinephrine's action at Alpha-2 receptors? What activates this action?
1. Increases K conductance - postsynaptic
2. Decreases cAMP - postsynaptic
3. Decreases Ca conductance - pre-synaptic
4. Clonidine
What is norepinephrine's action at Beta-1 receptors? What blocks this action?
1. Decreases K conductance
2. Increases cAMP
3. Propanolol
What is norepinephrine's action at Beta-2 receptors? What blocks this action?
1. Increase in electrogenic sodium pump
2. Propanolol
What is serotonin's action at 5-HT1A receptors? What is a partial agonist?
1. Increases K conductance
2. Buspirone
What is the action of Serotonin at a 5-HT2A receptor? What blocks this action?
1. Decrease K conductance
2. Increase IP3 DAG actibity
3. Clozapine, risperidone and olanzapine
What is the action of Serotonin at a 5-HT3 receptor? What blocks this action?
1. Increase cation conductance
2. Ondansetron
What is the action of Serotonin at a 5-HT4 receptor?
1. Decrease K conductance
2. Increase cAMP
What is the action of GABA at a GABA-A receptor? What facilitates this action?
1. Increase in Cl conductance
2. Benzodiazepines and zolpidem
What is the action of GABA at a GABA-B receptor? What activates this action?
1. Increases K conductance - post-synaptic
2. Decreases Ca conductance - pre-synaptic
3. Baclofen
What is the action of Glutamate at non-metabotropic receptors? What blocks NMDA receptors?
1. Increase in Ca or cation conductance
2. Ketamine, phencyclidine and memantine
What is the action of Glutamate at metabotropic receptors?
1. Decrease Ca conductance - presynaptic
2. Decrease K conductance with and increase in DAG and IP3 - post-synaptic
What is the action of Glycine at its receptor? What blocks this action?
1. Increases Cl conductance
2. Strychnine
What is the action of opioids at mu, delta and kappa receptors?
1. Decreases Ca conductance - presynaptic
2. Increases K conductance and decrease in cAMP - post-synaptic