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10 Cards in this Set
- Front
- Back
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What is the characteristic morphologic picture of Peripheral T cell lymphoma? (3 features) |
Diffuse infiltrate of lymph nodes that is composed of mixture of variably sized malignant T cells. Prominent infiltrate of reactive cells. Neoangiogenesis. |
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What is Anaplastic Large cell Lymphoma? |
Presence of rearrangements in the ALK gene . |
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What is the synonim for Anaplastic Large cell lymphoma? |
ALK positive. |
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What is the histologic characteristic of ALK + lymphoma? |
Large anaplastic cells, some containing horseshoe-shaped nuclei and voluminous cytoplasm, so called hallmark cells. The tumor cells cluster about venules and infiltrate lymphoid sinuses. |
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Why is the detection of ALK protein in tumor cells is a reliable indicator of an ALK gene rearrangements? |
Because it is not expressed in normal lymphocytes. |
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What is the prognosis of ALK + lymphoma? |
The cure with chemotherapy is 75%-80%. |
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What is Adult T cell Leukemia? Lymphoma? |
Neoplasm of CD4 T cells that is only observed in adults infected by human T cell leukemia retrovirus type 1 (HTLV-1). |
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What are the characteristic clinical findings in adult T cell lymphoma? 6 |
Skin lesions Generalize lymphadenopathy Hepathosplenomegaly Peripheral blood lymphocytosis Hypercalcemia |
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What cells are seen in Adult T cell lymphoma? |
Multilobated nuclei = clovrrleaf or flower cells. |
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What is the prognosis of adult T cell leukemia? |
Rapidly progressive disease that is fatal within months to 1 year despite aggressive chemotherapy. |
