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10 Cards in this Set
- Front
- Back
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What are the main differences between Chronic Lymphocytic leukemia (CLL) and small Lymphocytic lymphoma (SLL)? |
The degree of peripheral blood lymphocytosis. CLL lymphocyte count >5000. |
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What is the most common leukemia of adults? |
CLL |
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Does chromosomal translocations are common in CLL\SLL? |
No. They are rare. |
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What are the most common genetic anomalies in CLL\SLL? |
Deletions of 13q14,11q, and 17p and trisomy 12q. |
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What is the cell of origin in CLL\SLL? |
Postgerminal center memory B cell Naive B cell |
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What are the morphologic characteristic of CLL\SLL? 3 |
Diffuse infiltrate of predominantly small Lymphocytes with round slightly irregular nuclei. Proliferation centers- larger activated lymphocytes that gathered in aggregates, which contain mitoticaly active cells. Smudge cells. |
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What is the pathognomonic morphologic feature for SLL\CLL? |
Proliferation centers if present. |
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What is the immunophenotype of CLL\SLL? |
Pan B cell markers cd19,20,23,5. |
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What are the main clinical features of patients with CLL\SLL? 5 |
Generalized lymphadenopathy and hepathosplenomegaly Hypogammaglobulinemia Hemolytic anemia Thrombocytopenia
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What is Richter syndrome? |
Transformation to defuse large B cell lymphoma. 10-5%. This is bad prognostic feature |
