Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
MOA
|
Bactericidal
Binds to penicillin binding proteins which inhibit transpeptidase enzymes needed for cell wall crosslinking |
|
|
Biliary tract excretion
|
NAFCILLIN
AMPICILLIN |
|
|
PEN G
SOA |
Common strep, meningococci, gram + bacilli, spirochetes
|
|
|
PEN V
SOA |
Oral drug used mainly in oropharyngeal infxns
|
|
|
Penicillinase resistant
|
CLOXACILLIN
OXACILLIN NAFCILLIN DICLOXACILLIN (all Oral and parenteral) Methicillin (only parenteral) |
|
|
Penicllinase resistant SOA
|
Staph (usually staph. aureus)
|
|
|
AMPICILLIN
AMOXICILLIN |
Same as PEN G and H. influenza, E. coli, Listeria monocytogenese, Proteus mirabilis, Salmonella, enterococci
|
|
|
Anti-pseudomonas
|
TICARCILLIN, CARBENICILLIN, PIPERACILLIN, MEZIOCILLIN, AZLOCILLIN
|
|
|
B lactam inhibitors
|
Sulbactam + AMPICILLIN
Clavulanic acid + AMOXICILLIN Clavulanic acid + TICARCILLIN Tazobactam + PIPERACILLIN |
|
|
IMIPENEM
|
Greater resistance to betalactamase
SOA - anaerobic, Gram +, Gram -, not for MRSA or C. difficile Given w CILASTATIN AE: seizures |
|
|
MEROPENEM
|
Beta-lactam Abx
Like IMIPENEM but doesnt require CILASTATIN and less likely to cause seizures |
|
|
AZTREONAM
|
Beta-lactam Abx
SOA: gonococci, pseudomonas, H. influenza AE: skin rash, nausea, vomiting, abnormal LFT |
|
|
BACITRACIN
|
MOA: interferes w isoprenyl phospate in cell wall synth
SOA: H. influenza, staph, strep, clostridium, slamonella, shigella, proteus, pseudomonas Use: furunculosis, impetigo, pyoderma, carbuncle, abscesses, suppurative & infective corneal ulcers AE: toxic for systemic use |
|
|
VANCOMYCIN
|
MOA: interferes w D-alanyl-D-alanine cell wall units
SOA: C. difficile, methicillin resistant staph & cocci Use: pseudomembranous colitis, pneumonia, empyema, endocarditis, osteomyelitis, abscesses AE: thrombophlebitis, redman or redneck synd, ototoxic, nephrotoxic, neutropenia |
|
|
CYCLOSERINE
|
MOA: inhibits conversion of L-alanine into D-alanine for cell wall synth
Use: 2nd line against TB resistant to streptomycin, 2nd line against CNS nocardia AE: pyschosis, convulsions |
