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44 Cards in this Set
- Front
- Back
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most common renal tumor of infants? |
congenital mesoblastic nephroma |
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age during which congential mesoblastic nephroma usually presents? |
< 3-6 months |
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is congenital mesoblastic nephroma benign or malignant? |
benign |
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Is HTN a/w congential mesoblastic nephroma? |
NO |
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tx for congential mesoblastic nephroma? |
nephrectomy |
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is congential mesoblastic nephroma usually u/l or b/l? is it a/w polyhydramnios or oligohydramnios? |
u/l |
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mean age of diagnosis of wilms' tumor? |
3.5 years |
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genes/chromosomes a/w wilms' tumor |
WT1 - 11p13 |
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what is the classis triphasic pattern a/w wilm's tumor? |
Blastema, Epithelium, Stroma- Triphasic |
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What must you be concerned for if you see nephrogenic rests, esp if < 12 mo? |
b/l wilms' tumor |
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what is always present in b/l wilms tumor? |
nephrogenic rests |
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what is the most important prognostic factor in wilms tumor? |
histology (favorable) |
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how does wilms' present? |
large, smooth, firm flank mass |
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aniridia is a/w what childhood renal tumor? |
wilm's tumor |
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does wilms cross midline? |
No |
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does neuroblastoma cross midline? |
yes |
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are patients with wilms well or ill appearing? |
well |
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are patients with neuroblastoma will or ill appearing? |
ill |
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what is the treatment for wilms tumor? |
nephrectomy unless stage 5- partial after chemo |
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when do you use neoadjuvant chemo for wilms' tumor? |
B/L, unresectable, solitary kidney, extensive intracaval involvement |
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when and where do most wilms' recurrences occur? |
< 2 years after diagnosis |
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what syndromes is wilm's a/w? |
Denys- Drash |
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what do you find in a patient with Denys-Drash? |
wilms' tumor |
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what do you find in a patient with WAGR? |
Wilms' |
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what do you find in a patient with Beckwith-Wiedeman? |
wilm's |
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how often do you image (RBUS) patients with syndromes a/w wilms'? |
RBUS q 3 months |
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when does neuroblastoma present? |
< 4yo |
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homer-wright rosettes are a/w what childhood tumor? |
neuroblastoma |
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how does neuroblastoma present? |
hard, fixed, abdominal mass crossing midline |
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what lab value abnormalities in neuroblastoma? |
levated norepi |
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most common treatment for neuroblastoma? why? |
observation |
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if a patient presents with raccoon eyes (periorbital ecchymosis) what childhood tumor do you think of? why? |
neuroblastoma |
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if patient has localized, metastatic (skin, liver, bone marrow) neuroblastoma and age is < 1yo, what is the treatment? |
nothing. spontaneous regression |
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location of rhabdomyosarcoma with the worst prognosis? |
prostate > bladder |
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location of rhabdomyosarcoma with the best prognosis? |
vagina |
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childhood renal tumor with the worst prognosis overall? |
rhabdoid tumor of the kidney |
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rhabdoid tumor often metastasizes to where? what tests must be ordered? |
brain |
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treatment for rhabdoid tumor? |
nephrectomy then chemo (carboplatin, etoposide, cyclophosphamide) |
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average age of diagnosis of rhabdoid tumor? |
13 months |
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what is the treatment for children with large complex cystic lesions? |
nephrectomy |
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2 yo male patient presents with u/l, painless abdominal mass. cystic on imaging. what is most likely diagnosis? tx? |
multilocular cystic nephroma |
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common presentation of renal vein thrombosis |
abdominal mass, thrombocytopenia (decreased platelets), gross hematuria |
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mesoblastic nephroma |
most common solid tumor in NEWBORN benign but may be local invasive present ave 3.5 months, uncommon > 6mos a/w polyhydramnios 14% a/w congenital abnormality firm, rubbery no capsule or calcification prone to rupture microspindle cells Tx= rad nephrectomy, avoid tumor spill |
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what is the most important prognostic factor regarding wilms tumor? |
unfavorable histology |
