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137 Cards in this Set

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AGA
appropriate for gestational age
Neonate considered premature if born before_______________
37 weeks
What is the most sensitive indicator for well being?
a) weight
b) length
c) gestational age at birth
weight
SGA
a) small for gestational age
b) <10th percentile
c) <75th percentile
d) both a & b
small for gestational age
<10th percentile
Reasons a baby may be small for gestational age
a) malnutrition
b) toxic factors
c) placental insufficiency
d) all of the above
malnutrition
toxic factors
placental insufficiency
LGA
a) large for gestational age
b) > 90th percentile
c) r/t maternal diabetes
d) all of the above
large for gestational age
> 90th percentile
r/t maternal diabetes
The fetus whose mother has diabetes
a) has increased insulin production
b) does not have increased insulin production (because glucose doesn't cross placenta)
c) increased risk of polycythemia
d) increased risk of hypoglycemia
e) increased risk of hyaline membrane disease
has increased insulin production
increased risk of polycythemia
increased risk of hypoglycemia
increased risk of hyaline membrane disease
The most accurate measurement of gestational age
a) weight
b) crown-rump length
c) femur length
d) head circumference
crown-rump length
Length is the best measurement of ______________________
skeletal growth
IUGR
a) intrauterine growth retardation
b) r/t infection
c) r/t sick mom
d) dec. uteroplacental blood flow
e) drug/ETOH abuse
Intrauterine growth retardation
r/t infection
r/t sick mom
dec. uteroplacental blood flow
drug/ETOH abuse
ANS stability is achieved
a) @ 40wks
b) @ 60 wks
c) @ 2 years of age
d) @ 24 wks
@ 60 wks
Why would you not use restraints on an intubated preemie/neonate?
interferes with L & R brain development
Atropine should be given after/before/mixed with neostigmine
Before!!! to prevent bradycardia assoc with neostigmine
In regards to psychological development "Trust-mistrust"
a) Erik Erikson stage of development
b) up to 1 year old
c) requires an infant be protected from pain
Erik Erikson stage of development
up to 1 year old
requires an infant be protected from pain
T/F Nervous system elements required for the transmission of painful stimuli are functional by 24 weeks gestation
TRUE
T/F pain is especially harmful to preemie because the resources infant needs for growth and healing are used to cope with pain
TRUE
The most effective and specific indicator of pain in a preemie
a) crying
b) elevated HR
c) facial expression
d) withdrawal
facial expression
Non-pharmacological interventions for pain include
a) swaddling
b) pacifier
c) decreased enviro stimuli
d) sucrose as an analgesic
swaddling
pacifier
decreased enviro stimuli
sucrose as an analgesic
Social aversion
a) a result of painful stimulus
b) associates pain with human face
c) results in feeding difficulties
a result of painful stimulus
associates pain with human face
Oral aversion
a) a result of painful stimulus
b) from continued suctioning
c) results in feeding difficulties
d) results in failure to thrive
a result of painful stimulus
from continued suctioning
results in feeding difficulties
results in failure to thrive
CNS immaturity results in _________ to a specific stimuli and reflex control
a) a specific response
b) a global response
a global response
ANS immaturity leads to __________________________
BRADYCARDIA & APNEA
Myelination of brain & nerve endings progresses from ________to _______
head to toe
cephalocaudal development
A human is neurologically intact
a) shortly after birth
b) within 6 mths of birth
c) at 2 years of age
at 2 years of age
The moro reflex
a) startle reflex
b) sucking reflex
c) evident at 27 weeks inutero
d) evident after birth
startle reflex
evident at 27 weeks inutero
Grasp reflex
a) last only a few months
b) continues until gross motor skills are achieved
c) stronger in preemie than term infant
d) stronger in term infant than preemie
last only a few months
stronger in preemie than term infant
Laryngeal reflex
a) "diving reflex"
b) stimulated with oral/airway stimulation
c) can lead to laryngospasm
"diving reflex"
stimulated with oral/airway stimulation
can lead to laryngospasm
PSNS/SNS more developed in neonate
PSNS
meaning carotid/aortic baroreceptors not fully functional!
T/F General anesthesia decreases the threshold at which the body will respond to hypothermia
True
Why does the neonate's body favor heat loss?
r/t body/head ratio
The reason neonates don't sweat effectively is
a) immature epocrine glands
c) immature apocrine glands
immature apocrine glands
The neutral temperature in the preemie baby is > than or < that of the term baby
>, meaning that the body temperature of a preemie must be kept higher so that it will not expend any energy
Neutral temperature r/t thermoregulation of body temp
a) the temp at which no energy is expended to maintain body temp
b) the temp at which the body can't maintain normal body heat
the temp at which no energy is expended to maintain body temp

neutral temp (preemie) 34 degrees C neutral temp (term) 28 degrees C
T/F the critical temp for a preemie is equal to the neutral temp for a term baby
TRUE the critical temp for a preemie is 28 degrees C while the neutral temp for a term baby is 28 degrees C
Critical temp r/t thermoregulation of body temp
a) the temp at which no energy is expended to maintain body temp
b) the temp at which the body can't maintain normal body heat
the temp at which the body can't maintain normal body heat

Critical temp (preemie) 28 degrees C
Critical temp (term) 23 degrees C
Hypothermic stress
a) activates SNS
b) increases BMR
c) decreases surfactant production
d) increases O2 consumption
activates SNS (release of Epi/NE)
increases BMR
decreases surfactant production
increases O2 consumption
T/F the initial response to hypothermic stress is Tachycardia & HTN
True, then Bradycardia & Apnea
What happens when the brown fat needed for non-shivering thermogenesis runs out?
BRADYCARDIA & APNEA
Where is the brown fat needed for non-shivering thermogenesis located?
over upper portion of chest and back as well over the kidneys
IVH (Intraventricular Hemorrhage) results from
a) Hypoxia
b) Hypercarbia
c) Acidosis
d) hypothermia
e) hyperosmolar fluids
Hypoxia
b) Hypercarbia
c) Acidosis
d) hypothermia
e) hyperosmolar fluids
EVERYONE OF THESE LEADS TO HTN WHICH CAN CAUSE IVH!
IVH can result in
a) developmental delay
b) mental retardation
c) CP
d) hyprocephalus
e) need for VP shunts
developmental delay
mental retardation
CP
hyprocephalus
need for VP shunts
T/F glucose & bicarb are hyperosmolar fluids
True they must be cut in 1/2 with H2O to prevent risk of IVH
Ultimately IVH can lead to
BRADYCARDIA & APNEA
Place in order the development of fetal CNS
pons, forebrain, medulla, midbrain
Medulla
Pons
Midbrain
Forebrain
T/F at 27 weeks the fetus will startle to noise
True
What drug might possibly prevent neural tube closure defects?
Folic acid
Being the good CRNA before you start an IV on the neonate you want to prevent pain, somebody else says "hey put some EMLA cream on" you say.........
NO! the skin is too thin and it would be TOXIC to the neonate! GOOD FOR YOU!
The larynx in the preemie
a) C3
b) C4
c) C5
C3
Why did God put the larynx in the preemie/neonate/infant higher than the adult?
To prevent aspiration when taking bottle
Epiglottis
a) narrow/angled
b) wide
narrow/angled
Why (although controversial) is it that a cuffed ETT is not an absolute need in the newborn?
Because Trachea is funnel shaped
Newborn is an obligate
a) nose breather
b) mouth breather
nose breather
Fetus is capable of gas exchange
a) 20 weeks
b) 24 weeks
c) 30 weeks
24 weeks
When does surfactant start being produced?
Between 24-37 weeks
Newborn is an obligate
a) nose breather
b) mouth breather
nose breather
Surfactant
a) increases surface tension allowing alveoli to stay open
b) decreases surface tension making it easier for alveoli to expand
increases surface tension allowing alveoli to stay open
When does surfactant start being produced?
Between 24-37 weeks
Surfactant
a) increases surface tension allowing alveoli to stay open
b) decreases surface tension making it easier for alveoli to expand
increases surface tension allowing alveoli to stay open
A newborns lungs________than adult
a) more compliant
b) less compliant
less compliant
A newborns chest wall _________than adult
a) more compliant
b) less compliant
more compliant (that's why you see retractions with respirations)

Ribs are parallel instead of curved like Adults
The diaphram of a neonate
a) domed
b) flat
c) pulls down more than adult
d) pulls down less than adult
flat
pulls down less than adult

Can't get neg. intrathoracic pressure
so see retractions
Urine output
a) expect 1cc/kg/hr
b) minimum acceptable 0.5cc/kg/hr
c) both of the above
expect 1cc/kg/hr
minimum acceptable 0.5cc/kg/hr
Diaphramatic muscle fibers
a) slow twitch
b) high oxidative
c) fatigue resistant
d) amt have is < than adult
slow twitch
high oxidative
fatigue resistant
amt have is < than adult
When a neonate is in respiratory distress what will he do to keep his airways open?
Laryngeal braking
grunting/auto-peep
A decrease in FRC does what to O2 consumption and CO2 production?
DOUBLES BOTH OF THEM!
Neonate response to Hypoxemia
a) initial increased RR
b) initial increased VT
c) later decreased RR
d) later decreased VT
initial increased RR
later decreased RR

THERE IS NO CHANGE IN VT!!!!
How is the Newborn response to hypercarbia without hypoxemia different from the response to hypercarbia with hypoxemia?
With Hypoxemia there may be a suppressed response to Hypercarbia (so won't increase rate to breath it off)
T/F There is small airway closure with normal tidal ventilation in the neonate
True
What medication can be given to the mom of a fetus who wants to "come into the world" early?
Betamethasone, this stress dose will increase surfactant production
Fetal Hbg
a) right shift on oxyhgb curve
b) left shift on oxyhgb curve
c) holds on to O2
d) releases O2 readily
left shift on oxyhgb curve
holds on to O2
O2 consumption of neonate
a) 6cc/kg
b) 3cc/kg
c) 15cc/kg
6cc/kg
Hering Breur Reflex
a) "stretch" reflex
b) normal
c) in response to stress
d) causes periodic breathing
Stretch reflex, in response to stretching of lungs on inspiration, will cause periodic apnea, irregular breathing pattern

APNEA brought on by Bradycardia in response to stress is DIFFERENT!!
What is the narrowest part of the neonate airway?
subglottic area/cricoid cartilage
Typical sizes of ETT
a) 2.5 cm
b) 3.0 cm
c) 4.0 cm
2.5 cm
3.0 cm
How is the ETT depth determined?
Usually 3x the size
ie: 2.5 cm 7-8 cm depth
3 cm 9 cm depth
How do you determine whether the ETT is the right size?
By doing a leak test
If when adjusting pop off valve you hear (with precordial) air leaking around tube at 15cm the ETT is too small If hear air leaking around tube at a pressure > 25 cm the ETT is too big (IDEAL PRESSURE 15-25 cm)
Typical vent settings
a) low FiO2
b) VT 7-10cc;kg
c) Rate 30-60/min
d) pressure mode
low FiO2
VT 7-10cc;kg
Rate 30-60/min (look at ETCO2)
pressure mode (watch for easy rise in chest)
Why would you not want to use bronchodilators in a neonate?
Because lung tissue is friable
What is the danger associated with running high FiO2's?
Retinopathy of Prematurity
Hyperoxia causes dilation of retinal artery leading to detached retina
In a neonate with Right to Left shunting what would be the perfect SaO2?
a) 90%
b) 95%
c) 80%
d) 100%
80%
Because the PSNS is more active in the neonate what would the normal response to stress be?
BRADYCARDIA
T/F Cardiac Output in a neonate
is Heart rate dependent
True
Neonate heart ventricles
a) compliant
b) non compliant
non compliant STIFF right ventricle must adapt to being a volume chamber vs. a pump when transition to extrauterine life
Preemie PA pressure
a) 1/2 it's systemic BP
b) 1/3 it's systemic BP
c) The same as the systemic BP
1/2 it's systemic BP
Neonate PA pressure
a) 1/2 it's systemic BP
b) 1/3 it's systemic BP
c) The same as the systemic BP
1/3 it's systemic BP
The infants PA pressure is this as well
Cardiopulm transition to extrauterine life
a) decreases Pulm Vasc Resist
b) increases Pulm Vasc Resist
c) increased O2/decreased CO2
d) both a & c
decreases Pulm Vasc Resist
increased O2/decreased CO2
If using Sux or Pavulon as muscle relaxant what med would you want to pretreat with?
Atropine d/t bradydysrhythmias caused by those drugs
T/F Respiratory distress in the newly born infant recreates in-utero state
True which opens Duct Art. and result in shunting of blood to vital organs, CHF, widened pulse pressure, may result in NEC related to the shunting of blood away from the gut
What medication can be used to close the PDA?
Indomethacin but need to be cautious as it also decreases RBF which will increase creatinine
What is formula for K calculation in the symptomatic infant?
Desired K - Actual K = total dose
then
Total dose / 3 = hourly dose
Estimated Blood Volume
Preemie
Neonate
Toddler
Preschooler
School Age
Preemie 100cc
Neonate 90cc
Toddler 80cc
Preschooler 75cc
School Age 70cc
Neonate's renal function
a) immature until 6-12 mths
b) unable to concentrate urine if dehydrated
c) unable to dilute urine if overloaded
d) decreased GFR until 1 yr old
immature until 6-12 mths

unable to concentrate urine if dehydrated

unable to dilute urine if overloaded

decreased GFR until 1 yr old
Albumin binds
a) with acids
b) with bases
with acids
Alpha acid glycoprotein binds
a) with acids
b) with bases
with bases
Examples of acid drugs
a) phenytoin
b) narcs
c) LA's
d) NMBD's
phenytoin
NMBD's

as well as ASA, PCN
Examples of Basic drugs
a) Valium
b) LA's
c) Phenytoin
d) Narcs
Valium
LA's
Narcs

as well as atropine
Decreased protein & albumin binding
a) decreases amount of free drug
b) increases amount of free drug
increases amount of free drug
Bilirubin competitively binds with protein, what would knock the bilirubin off the protein and lead to kernicterus?
Hypoxia, Acidosis
T/F Fetal protein has a decreased binding affinity?
True
Which of the following would require you to give a higher dose of drug because of it
a) delayed metabolism
b) high volume of distribution
c) protein binding
high volume of distribution
protein binding (drugs such as muscle relaxants will bind to protein, making some of it "unavailable" for immediate use) But will require infrequent dosing as drug separates from protein and becomes available
Neonate "naivety" to drugs
a) requires a higher dose
b) requires lower dosing
requires lower dosing
Increased cardiac output
a) slows uptake of inhalation agents
b) increases uptake of inhalation agents
c) has no effect on inhalation agents as they are inhaled
slows uptake of inhalation agents
Neonates have a larger vessel rich group proportionally what does this do to uptake of inhalation agents?
Rapid equilibration
T/F The MAC required is usually more than the neonate heart can tolerate
True
Preemie MAC requirement less than/greater than term infant
less than
T/F MAC increases with age and then decreases by about 6 mths
True
Barbiturates
a) high amount of free drug
b) low amount of free drug
high amount of free drug
THIS IS RELATED TO THE LOW PROTEIN STORES
High dose Ketamine
a) increases SNS stimulation
b) increases PSNS stimulation
c) can lead to paradoxical apnea
d) may be used for tamponade
increases SNS stimulation
can lead to paradoxical apnea
may be used for tamponade
T/F Narcotics can lead to Bradycardia/Apnea which decreases cardiac output
True BECAUSE CARDIAC OUTPUT IS HEART RATE DEPENDENT
Myleomenigocele
failure of neural tube to close, ( before 28 days gestation) Thoracic/Lumbar sacral most common
Repair of a Myleomenigocele should be done
a) emergently
b) once stablized
emergently
What s/s might make you suspect a Tracheoesophageal Fistula?
inability to pass a NG tube, increased oral secretions, GI distention regurgitation, cyanosis
Repair of a Tracheoesophageal Fistula should be done
a) emergently
b) once stablized
once stablized
What other anomalies are associated with Tracheoesophageal Fistula?
VATER
Vertebral/Vascular
Anal malformation
TracehoEsophageal
Renal/Radial deformities
What other anomalies are associated with Tracheoesophageal Fistula?
VACTERL

Vertebral/Vascular
Anal malformation
Cardiac anomolies
TracehoEsophageal
Renal/Radial Limb deformities
What position would you place a neonate with Tracheoesophageal Fistula in for surgery?
a) prone
b) supine
c) right lateral
d) left lateral
left lateral
Where would you place the pre-cordial on a neonate undergoing Tracheoesophageal Fistula repair
a) right side
b) left side
c) makes no difference
left side
What needs to be done before the repair of Tracheoesophageal Fistula?
a) correct metabolic abnormalties
b) hydrate
c) both of the above
correct metabolic abnormalties
hydrate
How could you place the ETT in a patient undergoing Tracheoesophageal Fistula repair so that you would have the best ventilation?
above carina, with anterior rotation so that ventilation of fistula is avoided

AVOID + PRESSURE VENTILATION PRIOR TO INDUCTION
Tracheoesophageal Fistula more common in
a) males
b) females
males
Congenital Diaphragmatic Hernia
Invades chest cavity on LEFT SIDE (most common) thru Foramen of Bochdalek (8-10 weeks gestation)
Why after repair of Congenital Diaphragmatic Hernia would you not want to reinflate the lung?
Because lung is HYPOPLASTIC (the small lung is NOT r/t atelectisis)

PEAK AIRWAY PRESSURE no greater than 25-30 mmHg
What side is the pre-cordial placed on a neonate undergoing repair of Congenital Diaphragmatic Hernia
a) left
b) right
c) makes no difference
Right
What other anomalies are associated with Congenital Diaphragmatic Hernia?
Myelomenigocele
Hydrocephalus
PDA
Esophageal atresia
With Congenital Diaphragmatic Hernia
a) increased PVR
b) decreased PVR
c) R to L shunt
d) L to R shunt
e) decreased O2
increased PVR

R to L shunt

decreased O2
Where would you want to place peripheral IV's in a neonate undergoing
repair of Congenital Diaphragmatic Hernia?
a) upper extremities
b) 1 in the upper extremity & 1 in the lower extremity
c) makes no difference
upper extremities because once hernia is repaired there will be increased intra-abdominal pressure compressing on IVC)
Gastroschisis
a) right lateral abd defect
b) has a sac over it
c) no covering
d) associated with other anomalies
right lateral abd defect
no covering
Where would you want to place peripheral IV's in a neonate undergoing Gastroschisis repair
a) upper extremities
b) 1 in the upper extremity & 1 in the lower extremity
c) makes no difference
upper extremities, with surgical repair there will be increased intra-abd pressure (in fact this surgery may be done in stages to prevent the high pressures)
Omphalocele
a) herniation of bowel into umbilicus
b) has a sac over it
c) no covering
d) associated with other anomalies
herniation of bowel into umbilicus
has a sac over it
associated with other anomalies (Cardiac, Downs, Preemie)
Necrotizing Enterocolitis
a) develops with stress in preemies < 36 weeks
b) associated with PDA many times
c) can be prevented with breast feeding
d) surgical repair results in high blood loss
a) develops with stress in preemies < 36 weeks
b) associated with PDA many times
c) can be prevented with breast feeding
d) surgical repair results in high blood loss
PDA ligation
a) required for incomplete closure of Ductus Arteriosis
b) placed in Right lateral position
c) will require re-inflation of lung after ligation
d) all of the above
a) required for incomplete closure of Ductus Arteriosis
b) placed in Right lateral position
c) will require re-inflation of lung after ligation
If during the ligation of a PDA your neonate suddenly drops his BP and then loses his postductal then preductal SaO2 you would suspect
a) ligation aorta
b) ligation PA
c) ligation of PDA
ligation aorta
If during the ligation of a PDA your neonate suddenly drops his SaO2 and then loses his BP or it drops very low and progresses to Bradycardia you would suspect
a) ligation aorta
b) ligation PA
c) ligation of PDA
ligation PA
If during the ligation of a PDA your neonate has a decrease in pulse pressure, and a narrowing of pre/post ductal SaO2's you would suspect
a) ligation aorta
b) ligation PA
c) ligation of PDA
ligation of PDA THIS IS WHAT YOU SHOULD SEE!
Where should SaO2 monitors be placed on a neonate undergoing ligation of PDA?
a) R hand (preductal)
b) L hand (preductal)
c) L or R foot (postductal)
d) L or R foot (preductal)
R hand (preductal)
L or R foot (postductal

A BP cuff should also be placed on the lower leg
Stress associated with PDA is associated with?
NEC Necrotizing enterocolitis
What position is a neonate undergoing PDA ligation placed in?
a) left lateral
b) supine
c) right lateral
right lateral