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1289 Cards in this Set

  • Front
  • Back
How long s/p birth:

-Colustrum available
-Milk available
Colustrum: immed
Milk: w/in 40h
Infant WCC:

What s/sx is most sensitive indicator of NUTRITIONAL status?
WEIGHT
S/p birth:

Neonate feeds how many times in first 24h?
Immed --> 8-12x
What age:

Introduce free H2O?
4-6mo

(once taking solid foods)
First days of life: does colustrum meet nutritional reqs?
YES
0-6mo:

Does soy formula have enough protein?
yes
Is it safe to combine formula concentrate with water in 1:1 ratio?
YES - if concentrate

Never safe to dilute non-concentrated formula to "stretch it out"
Calorie reqs for infant that is:

-term
-preterm
-very low bw
Term: 100-120 cal/kg/d

Preterm: 115-130

Very low bw: 150
Do breast-fed infants req vitamin D? Formula fed?
ALL infants req supp vitamin D
ALL infants (breast & formula) req what supplement?
Vitamin D
What age:

Introduce solid foods (rice cereal)
4-6mos
(IRON-fortified solids)
(many premies NOT ready for solids at 4mos)
What age:

Eat STRAINED foods (pasta, toast, banana)
9mos
9mo: req how many calories/day? What % from milk/formula?
100 cal/kg/d

75% breastmilk/formula
What age:

Infant feeds themselves
9mos
What age:

Introduce toast, pasta, banana
9mo
What age:

Introduce MEAT
9mo
Infant: how often introduce 1 new food?
q5-7 days start 1

(ID allergies)
Infant:

when introduce hot dog?
NEVER - choke
Term infant:

Gains how much wt per day?
20-30 g/day
4mo: weights ____x birth weight
2x bw
What age:

Weigh 2x birth weight
4mo
What age:

Weight 3x birth weight
12mo
1yo: weighs ___x birth weight
3x
<1yo:

-# wet diapers per day
-# stools per day
6+ wet

6-8 stools
What age:

2x birth LENGTH
4mo

(same as 2x birth weight)
4mo: ___x birth length
2x length
Red reflex: hold opthalmoscope how far from infant?
10 inches
Red reflex: what 1st see?
at BIRTH
Red reflex present or absent?:

Cataracts
Absent
Red reflex present or absent?:

Glaucoma
Absent
Red reflex present or absent?:

Retinoblastoma
Absent
Red reflex present or absent?:

Chorioretinitis
Absent
Rectal exam on infant:

-when perform? (what scenario)
-what position hold infant?
Only if abd mass; not part of routine

Pt SUPINE (on back) --> flex knees
Enlarged thyroid common or rare in child?
RARE
Enlarged LNs:

-common or rare in toddler?
-non/tender?
-shotty located in what areas?
Common
NT
Shotty in ANT & POST cervical
Murmur in toddler:

-most non/fxnl?
FUNCTIONAL
NEW murmur: common due to congen HD?
No
--rarely 2/2 congen
In-toeing in toddler: commonly due to what anatomic variant?
Tibial torsion
Tibial torsion in toddler: leads to what type of gait?
IN-TOEING
What is youngest age you administer INFLUENZA?
6mo
Immunization S/E: fussy + fever

-how long last?
-need to see doc?
Commonly last 24h

If >24 --> see doc
What age:

Baby sleeps through night
4-6mo
How position in car:

<1yo
carseat, middle back seat, face back
How position in car:

<10kg
carseat, middle back seat, face back
How position in car:

1-4yo
Carseat, backseat, face forward
How position in car:

4-8yo
Booster, back, forward
How position in car:

8-12yo
Backseat, face forward
SURVEY or SCREEN?:

Bright futures
Survey
SURVEY or SCREEN?:

PEDS test
Screen
SURVEY or SCREEN?:

M-CHAT
Screen
What is name for peds SURVEY most commonly used?
Bright Futures
What age:

Laughs, smiles
2mo
What age:

Sits unsupported
6mo
What age:

Look for dropped item
6mo
What age:

Stranger RECOG
6mo

(contrast anxiety- 9mo)
What age:

Stand w/support
9mo
What age:

mama, dada (nonspecific)
9mo
What age:

Patty-cake
9mo
What age:

STRANGER ANX
9mo
What age:

Stands alone
1yo
What age:

Mama, Dada - SPECIFIC
1yo

(contrast non-specific - 9mo)
Infant screening: do low measures of social/cog & language --> predict intellectual delays?
YES
What age:

Tricycle
3yo
What age:

CIRCLE
3yo
What age:

Cross
3yo
What age:

Knows name, age, sex
3yo
3yo: can draw what shape?
Circle, cross
What age:

Knows 2 actions, 1 color
3yo
3yo: knows how many actions? colors?
2 actions
1 color
What test:

Parents answer illustrated 30-item question at designated intervals
Ages & Stages Questionarre (ASQ)
What test:

5 key areas (commun, gross & fine motor, prob-solv, personal/social)
Ages & Stages (ASQ)
Ages & Stages Questionairre (ASQ):

-use what ages?
-how many Qs?
-how long to fill out?
-tests what areas?
0-5yo (contrast PEDS - 0-8)
30 Qs
10-15 min
5 areas: communication, gross motor, fine motor, prob-solving, social/personal
Low or high sens & spec:

-ASQ
-PEDS test
Both high spec & sens
What test:

parent answers Y/N/sometimes --> color-coded score --> user guide to assess risk
ASQ
PEDS test:

-useful what ages?
-how many Qs?
-what are 2 uses?
0-8 yrs
10q (3 min)
uses:
1. Develop screen test
2. Assess parent's concerns
What test:

10 questions --> use to screen development OR assess parent's concerns
Parent's Eval of Developmental Status (PEDS test)
What test: used in:

-0-5yo
-0-6yo
-0-8yo
0-5: ASQ
0-6: Denver II
0-8: PEDS
What test:

Reqs direct observation & parent report
Denver II
Denver II:

-use what ages?
-tests what areas?
-low,mod or high sens & spec for development delay?
0-6yo
Tests (4): gross, fine, language, social
MODERATE sens & spec
What test:

TEACHES developmental milestones
Denver II
What test:

Reqs child cooperation --> time-consuming
Denver II
Premature birth:

CORRECTED AGE =
Chronologic age - days/mos prematurity
Neuroblastoma in abdomen <1yo:

-sympto? jaundice?
-how affect G&D?
Asympto, no jaundice

May see normal G&D
What dz:

Abd CT: heterogeneous, cystic mass with calcifications
Neuroblastoma
Neuroblastoma in abdomen <1yo:'

2 sites of mets
Chest LNs
Posterior mediastinum
What dz:

Small round BLUE CELLS
Neuroblastoma
(e.g. abdominal)
Neuroblastoma in abdomen <1yo:

How appear tumor cells (histo)
small round blue cells
What dz:

Bone marrow ROSETTES
Neuroblastoma
What dz:

Tumor cells w/dense, hyperchromic nuclei
Neuroblastoma
Neuroblastoma in abdomen <1yo:

How affect CBC?
BM infiltrate --> ANEMIA, other cytopenia
Neuroblastoma in abdomen <1yo:

In/decrease urine HVA:VMA?
INCREASE
What dz:

Abdominal mass in infant + increased HVA/VMA
Neuroblastoma
Wilms tumor: see LAD?
NO
Abdominal neuroblastoma:

CT appears homo/heterogeneous? cysts?
HETERO
CYSTS (hemorrh, necrosis)
Which has more hemorrhage & necrosis:

Wilms tumor or neuroblastoma?
Neuroblastoma

(appears more cystic on CT)
What dz:

Abd mass + heterogenous mass (CT) + PSEUDOCAPSULE
Wilms tumor
Wilms tumor: CT shows demarcation b/w tumor & parenchyma?
YES
=pseudocapsule
Wilms tumor:

where mets?
PULM (see on CXR)

(contrast neuroblastoma - mets to chest LNs & post mediastinum)
Wilms tumor: req BM aspiration?
NO - only if:
1. pain
2. unfavorable tumor histo
Wilm's tumor: affect UA?
Yes - hematuria
Abdominal TERATOMA in infant: common or rare?
RARE
Abdominal teratoma:

see jaundice? pallor?
No neither
Hepatic tumor in infant: common or rare? see jaundice? affect G&D?
RARE
jaundice
decreased G&D
Anemia in 3yo:

#1 etio
Iron-deficiency 2/2 malnutrition
Anemia in 3yo:

Is anemia itself a good predictor of Fe2+ deficiency?
NO -- poor predictor of iron def in diet
HIV in infant: expect anemia?
YES (ACD)
What dz:

Microcytic anemia with decreased RDW
thalasemmia, sickle cell dz
Micro/normo/macro anemia:

-SCD
-Thal
Both MICRO
Mild (>9) or severe (<9) anemia:

Aplastic anemia
severe
Mild (>9) or severe (<9) anemia:

Folate deficiency
severe
Mild (>9) or severe (<9) anemia:

B6 deficiency
Severe
What 3 nutritional defs can cause anemia?
Iron
Folate
B6
3yo w/IDA: req iron supplement OR can just encourage iron-rich foods?
Give Fe2+
INITIAL labs in anemia w/u:

-retic?
-smear?
YES
INITIAL labs in anemia w/u:

-stool blood?
-UA?
YES
Iron-def anemia:

-micro/macro?
-hypo/hyperchromic?
-DEC/INCREASED retics?
Micro, hypo

DECREASED RETICS
Hemophilia A or B:

Decreased VIII
A
Hemophilia A or B:

Decreased IX
B
Hemophilia A: what def?
Decreased VIII (8)
Hemophilia B: what def?
Decreased IX (9)
Hemophilia: how affect:

-PTT
-Bleed time
PTT: prolonged

Bleed time: normal
What dz:

Prolonged PTT, normal bleed time
Hemophilia
How inherit:

Hemophilia
X- RECESSIVE
How inherit:

vWD
AD
What dz:

-prolonged PTT, normal bleed time
-prolonged bleed time, normal PT
HemoPhilia: prolonged PTT, normal bleed time

vWD: prolonged bleeD time, normal PT
What dz:

Post-tonsillectomy bleed
vWD
What dz:

Epistaxis
vWD
What dz:

Gingival bleed
vWD
vWD: how inherit

-Type I
-II
-III
I&II: AD

III: AR
vWD: what is defect in:

-type I
-II
-III
I: decreased vWF (mild)
II: QUAL defect
III: undetectable vWF (severe)
vWD: which TYPE?

Decreased vWF; MILDEST
I
vWD: which TYPE?

Most common (70%)
I
vWD: which TYPE?

inherited AR
III
vWD: which TYPE?

QUAL defect
II
vWD: which TYPE?

Undetectable vWF
III
vWD: which TYPE?

Most severe
III (undetectable vWF)
vWD: how tx?
Intranasal OR IV desmo
What dz?:

Tx w/intranasal or IV desmopressin
vWD
Atopic dermatitis: 2/2 what TWO immune mxns?
1. Increased IgE
2. Dysregulated Ab production

(encoded by DIFFERENT gene sets)
Atopic dermatitis:

-apply lubricant?
-admin anti-inflamms?
Yes- lube

ST anti-inflamms (alternate b/w low & high concens)
What age:

Able to eat at table
3yo
3yo nutrition: normal to prefer BLAND foods?
yes
What age:

1st dentist visit
3yo
What age:

d/c bottle
1yo
3yo: limit how many meals & how many snacks?
3 meals, 2 snacks
Can you give pre-schooler: H2O w/ice?
YES - prefer
How determine:

WEIGHT AGE
Age at which wt plots @ 50%
Predispose to UNDER or OVERweight:

Bardet-Biedl syndrome
Over
Predispose to UNDER or OVERweight:

Cohen syndrome
Over
Does high birthweight correl w/childhood obesity?
YES
What % of 6-19yo are obest?
15%
Childhood obese: assoc w/SES?
Yes -- low SES
What % will become obese adults?:

-obese 4yo
-obese adolescent
4yo --> 20% obese adults

adol --> 80% obese adults
What is increased risk that child will be obese:

-1 obese parent
-2 obese parents
1: 3x
2: 10x
Normal 3yo: which is stronger predictor of obesity in adulthood:

Child's current wt OR parental obesity
Parental obesity
Early adolescence: normal to see dec/increase insulin sensitivity?
Adol --> DECREASE insulin sensitivity (i.e. normal to see transient insulin resistance) --> increase wt gain
Menarche --> increase/decrease risk of obesity?
Increase
BMI =
Kg/m2
BMI: what # and %tile:

-overweight
-obese
Over: 25-30 (85-95%)

Obese: >30 (>95%)
What fraction of obese children are hypertensive?
1/3
Obesity: assoc with restrictive lung disease? reactive?
Restrictive (inc OSA, pickwick)

NOT assoc w/reactive
Obesity: assoc w/Blount disease?
YES

(outward bowing of tibia)
What dz:

Wide physis (hip x-ray)
SCFE
SCFE: wide or narrow physis?
WIDE
SCFE: displace what 2 components of femur?
HEAD & NECK (thru physeal plate)
What dz:

obese kid w/delayed sex maturation & antalsic gait
SCFE
SCFE: see limited INT or EXT rotation of hip?
limited INTERNAL rotation
ADHD: sxs for how long? # settings?
6+ mos and before 7yo
2+ settings
ADHD: req how many sxs (inattn or hyper)?
6+
(either type)
How distinguish inattention ADHD from sleep disorder (e.g. OSA)?
Sleep: decreased sleep & tired

ADHD: poor sleep but NOT over-tired
MDD in child: high rate of converting to what psych condition?
MANIA
ADHD: assoc w/oppositional defiance disorder? conduct disorder?
BOTH
ADHD: how tx? (1 drug; know dosing)
Sustained-release methylphenidate (concerta) 18mg po bid

BIDBIDBID
T2DM: accounts what % total child DM?
10-50%
Childhood DM: inc/decrease appetite?
INCREASE (polyphagia)
What # to dx DM:

-Random BG
-Fasting
-2h OGT

--Which method preferred to dx DM?
Random: >200
Fast: >120
2h OGT: >200

FASTING PREFERRED
DM: screen ALL overweight children? when start screen (2 options)? screen how often?
Screen if: overwt (85%) + 2 (Fhx, sxs, etc)

Start 10yo OR puberty onset

Screen q2 years
How define NORMAL BP in child?
Both SBP & DBP <90% (age/gender/ht/wt)
What age:

Start routine BP check
3yo
Name for: SBP & DBP:

-90-95%
-95-99%
->99%
90-95%: pre-hypertension
95-99%: stage I HTN
>99: stage II
What % SBP & DBP:

Pre-hypertension
90-95%
What % SBP & DBP:

Stage I HTN
95-99%
What % SBP & DBP:

Stage II HTN
>99%
Increased BP in >6yo: most due to 1' or 2' HTN?
PRIMARY
What dz:

Young child with HTN + no family hx HTN
Ao coarctation
Childhood HTN: damages which heart chamber?
LVH
Order what labs: obese child with:

-85-95%, no risks
-85-95%, risks
->95%
Order what labs: obese child with:

-85-95%, no risks: fasting lipids
-85-95%, risks: ALT, AST, BG
->95%: BUN, Cr
Obese child: how tx:

-85-95%
>95% in pre-teen, teen
85-95: slow wt GAIN (until <85%)

95: active wt loss (gradual)
Pre: <1lb/mo
Teen: 1 lb/mo
Obese child:

-limit TV hrs?
-amt exercise
TV <2h

Exercise: 60min every day
Pedigree: try to get how many generations?
3rd
How inherit:

Marfan
AD

(DOM!)
How inherit:

neurofibromatosis
AD
How inherit:

Duchenne's Musc Dys
XR
How inherit:

MELAS
mito
Is it EVER possible for male to transmit mito dz?
Rare; can see if nuclear gene mutation --> dysreg mito protein
How inherit:

CF
AR
How inherit:

Tay-Sachs
AR
Name for:

genetic test to determine the effects of a med
Pharmacogenetics
All states req neonatal screen for what 2 dzs?
1. PKU
2. Hypothyroid
What imaging:

Posterior fossa
MRI
#1 SOLID childhood cancer
Brain tumor
Ped brain tumor:

Neuroectodermal tumor comprise what % ped brain tumors?
25%
What is most common TYPE of brain tumor (histo)?
Neuroectodermal (medulloblastoma) - 25%
Astrocytoma: more common in cerebellum or brainstem?
Cerebellum
Ped brain tumor: which more common:

astrocytoma or glioma
astrocytoma
How tx: unresectable brain tumor?
Surgical histo confirm --> XRT & chemo, possible BMT
Non- or Lateralizing ataxia:

Cerebellitis
NON (affects entire cerebellum)
L cerebellar tumor:

-fall which direction?
-nystagmus which direction?
-past-pointing in which direction?
ALL LEFT
If pt presents with LEFT-sided nystagmus --> suspect tumor on WHICH HEMI?
LEFT CEREBELLUM
Basilar migraine: see:

-vomit?
-vision change?
-increased ICP?
Vomit & vision change

NO INCREASE ICP
#1 etiology ataxia in child
CEREBELLITS

(No increase ICP)
Can toxins/meds increase ICP? See non/lateralizing ataxia?
YES! Can increase ICP --> NON-lateralizing ataxia & nystagmus
Delivering bad news: is it OK to TOUCH pt?
YES
Teen interview: should you set up expectation for interview at beginning?
Yes
Teen: start with specific OR open-ended questions?
SPECIFIC
Teen interview: if parent refuses to leave --> should you advocate for adolescent privacy?
Yes
T/F offer HIV test to ALL sexually-active >13yo
TRUE
Normal range puberty:

-F
-M
F: 8-13yo

M: 10-15yo
Tanner staging: assess what 2 features (M, F)?
M: pubes, testes
F: pubes, breasts
Name for:

Measure of BODY COMPOSITION
anthropometry
Which measure:

Most sensitive indicator of growth abnormalities
growth VELOCITY
PTT: intrins or extrins?
Extrins
EBV: what % 35-40yo infected?
95%
EBV: infection in adol --> what % develop mononucleosis?
35-50%
EBV:

-fever?
-LAD?
-sore throat?
-how long is incubation?
fever + sore throat + swollen LNs

Incubates 4-6w
HIV+ mother --> what % risk infection (if untreated)?
25-30%
Maternal HIV: increase risk transmission if:

-SVD or C/S?
-ROM > ___h
-what gestation?
SVD
ROM >4h
<37w
Mother w/unknown HIV risk --> would you perform newborn screen?
YES
Neonatal HIV: see splenomeg?
possibly
TORCH: what stand for?
Toxo
Other: HIV, HBV, parvo, syph
Rub
CMV
HSV-2
Congenital toxo: how screen:

-0-6mo
->1yo
0-6mo: infant IgM or IgA

>1yo: IgG
Does presence of maternal HBcAb predict risk transmit? HBsAg?
HBcAb: no (could indic past infnx)

HBsAg: yes
Next step: presence of HBsAg in mother --> ?
Give mother AND neonate:
1. HBV vaccine
2. HBIg
Detect via what test:

Maternal HIV
PCR
Congenital rubella: how test:

-0-6mo
->1yo
0-6mo: IgM

1yo: IgG
Congenital CMV: how detect in neonate? next management step?
URINE CULTURE in weeks 0-3

(if pos --> routine hearing test)
Which congenital infection:

if positive --> routine hearing test
CMV
CMV:

-hearing loss abrupt or progressive?
-occurs birth or 1yo?
Progressive

Can occur birth OR up to 1yo (continuously monitor)
What dz:

Infant w/microcephaly, intracranial Ca2+, lissencephaly, rash
congenital CMV
CMV:

-what structure see Ca2+?
-in/decrease # gyri?
-assoc w/eye findings?
Ca2+ esp in frontal horns of lat vents
Lissenceph: decrease gyri, increase cortex thickness
Chorioretinitis
congenital CMV: how tx neonate?
Antivirals ONLY IF BABY IS IMMUNOCOMPROMISED
Routine neonate meds:

-how admin vitamin K?
-Erythro eye drops covers which STD?
IM vitamin K

Gonococcus
Another name for:

Pediculosis capitis
Lice
Nits =

- firm or loose attach to hair shaft?
egg CASES of lice

firm attach --> difficult to remove
What dz:

5-10mm linear lesions
Scabies
Scabies: related to cleanliness?
NO
What dz:

SARCOPTES
Scabies

(Sarcoptes scabiei)
Scabies: how acquire?
Close contact
Scabies: what causes itchiness? When is itching worst?
Laying of eggs (NOT mite bites)

Worse at night
Scabies: common locations?
wrist
elbow
finger
toe
Scabies: how dx?
Scrape MULTIPLE lesions (burrows or papules) --> mineral oil --> light micro --> see mite, egg or FECAL PELLET
What dz:

Diagnose by scraping lesion --> mineral oil --> see FECAL PELLETS
Scabies
What dz:

Scaling, cracks & fissures b/w toes
Tinea pedis
Tinea versicolor: infection with what form of fungus?
YEAST form
Tinea versicolor: predisposed by excess HUMIDITY or DRYNESS?
humidity
Tinea versicolor: do lesions have scale?
YES - fine scale
What dz:

Lesion turns pink --> brown --> white; fine scale
Tinea versicolor
Tinea versicolor: how tx?
Selenium sulfide lotion
Selenium sulfide lotion:

tx what dz?
Tinea versicolor
Tinea versicolor:

-recurrence common?
-how long for pigment to normalize?
Common

May take mos to return pigment to normal
Tinea capitis:

-How tx? (drug, duration)
-2 alt txs
SYSTEMIC griseofulvin (6-8w)

Alts: terbinafine, itraconazole
What is dz:

Skin lesions dx as eczema & treated w/steroids --> worse lesion
TINEA

(misdx as eczema --> steroids worsen tinea)
Name for:

Allergic response --> inflamed, weepy boggy lesion
Kerion
Kerion: what is underlying mxn? HOW TX?
Allergic response --> inflammed, weepy boggy lesion

Tx: ORAL steroids
Which is more predictive of LT neuro outcomes:

Umbilical artery blood sample OR APGAR
Umb art
Perinatal asphyxia: detect via sampling which blood vessel in cord?
Umb ARTERY --> detect hypoxia, acidosis

(NOT vein)
GDM: predispose neonate to:

-hypo or hypergly?
-hypo or hyperCa?
Hypogly (due increased insulin)

HypoCa2+
GDM: is neonate at increased risk of resp distress?
YES
Fetal glucose: normally what fraction of maternal glucose?
2/3 maternal glucose

(glucose crosses placenta)
GOAL BLOOD GLUCOSE IN NEONATE
41-50
Persistent pulmonary HTN of newborn:

-underlying etio
-where does blood divert?
Due elevated pulm vasc R

Blood divers through ductus arteriosus & PFO (bypasses lungs)
Persistent pulmonary HTN of neonate: presents with tachy/bradycardia?
Tachy

(also tachypnea)
Cyanotic newborn: order an O2 challenge test?
YES
Acrocyanosis at birth:

-usu resolves after how long?
-when start to suspect congenital HD?
Usu resolves 4-5h

After 8h warming --> suspect congen HD
#1 etio respiratory distress in preterm
Resp Distress Syndrome (RDS)

aka Hyalien Membrane Dz
Respiratory Distress Syndrome in neonate:

underlying etio
Surfactant deficiency
Name for:

Neonatal dz caused by surfactant deficiency
Respiratory distress syndrome
Respiratory Distress Syndrome in neonate:

-genetic component?
-M or F?
-C/S or SVD?
More common if siblings w/RDS
M > F
C/S w/out labor > SVD
Respiratory Distress Syndrome in neonate:

If mother has GDM --> may see RDS in infant up until how many weeks gest?
37
Neonatal with resp distress: which is more common if healthy mother and gest >34w:

RDS or transient tachypnea of newborn
TTN
How distinguish (what test):

RDS vs. TTN
CXR

RDS: air bronchograms, ground glass
What dz:

Newborn with resp distress & CXR w/bronchograms & ground glass
RDS
Transient tachypnea of newborn:

More common term or preterm?
TERM !!!!
Transient tachypnea of newborn:

Underlying etio
Delayed fluid clearance
Transient tachypnea of newborn:

Early or late onset?
Mild or severe distress?
Early onset, mild distress
Transient tachypnea of newborn:

-M or F?
-C/S or SVD?
-micro or macrosomy
M > F (same as RDS)
C/S (same as RDS)
MACROSOMY (esp DM)
What dz:

Neonate w/resp distress & CXR w/perihilar streaking, coarse densities and WET LOOKING lungs
TTN

(contrast RDS: bronchograms, ground glass)
TTN or RDS:

Male
BOTH
TTN or RDS:

Perihilar streaking
TTN
TTN or RDS:

Fluffy densities
TTN

(contrast RDS: ground glass)
TTN or RDS:

Lateral view shows fluid in pleural space, fissures
TTN
TTN or RDS:

WET LOOKING LUNGS
TTN
Pneumothorax:

More common in premie?
YES
Neonatal sepsis/PNA: assoc w/PROM?
Yes - may have subtle early findings like poor feed, lethargy
Meconium aspiration: occurs when in birth process?
In utero

OR

1st breath
TTN: expect to resolve after how long?
12h
APGAR:

-how many categories?
-points?
5 categories - appear, pulse, grimace, activity, resp

2pts each
Are low 1- & 5-min Apgars markers of intrapartum hypoxia?
NO - not conclusive
Which is better predictor of neonatal death:

1- or 5-min apgar
5-min

(although best is umb art sample)
What birthweight #s:

Extremely low bw
<1,000 g

(contrast very low: 1k - 1,499)
What birthweight #s:

Very low bw
1,000-1,499
What birthweight #s:

Low bw
1,500 - 2,499

(contrast very low: 1,000-1,499)
What birthweight #s:
NORMAL
2,500 - 4,000
Ballard score: estimates what? includes what criteria?
Gestational age (s/p birth)

Criteria: neuromuscular & physical maturity
Dubowitz exam: what 3 categories?
Estims gestational age (alternative to Ballard score; older tech)

1. Preterm (<37w)
2. Term
3. Post (>42)
Cephalohematoma: 2/2 what device?
VACUUM
If baby is LGA --> risk hypo or hypergly?
HYPO

(same if baby is SGA --- inadeq glycogen stores)
If baby is SGA --> risk hypo or hyper gly?
Hypo (2/2 low glycogen store)

Same if baby is LGA (2/2 overproduction of insulin)
SGA neonate: expect pale or ruddy?
RUDDY --- due polycythemia --> increased viscosity
Premature infant: do you need to establish breast-feeding before discharge?
YES

(risk hypothermia, decreased glycogen stores)
Newborn:

Is 1st phys exam (at birth) a good indication of successful transition to extrauterine?
YES
Newborn:

1st breath --> where does fluid in lungs go?
Squeezed out (cxns, air) --> absorbed by PULMONARY LYMPHOCYTES
0-1h life: normal V/S:

-pulse
-rr
p 160-180
rr 60-80
2h life: normal V/S:

-pulse
-rr
p 120-160

rr 40-60
2h neonate: suspect resp distress if RR > ____
rr > 60
Neonate:

Use glucometer to confirm hypogly?
NO - use to SCREEN
(NOT confirm)
Neonate glucometer read:

If neonate BG <40 ---> what is next step?
Meas serum BG (to confirm neonatal hypogly)

START TX WHILE WAITING
Neonate glucometer:

Start tx if neonatal BG < ___
<40
If neonate with RDS --> order what 3 tests?
1. CBC w/diff
2. Blood cx
3. LP
Tx hypoglycemic neonate if:

-symptomatic and BG <___
-asympto and BG <___
sympto & <45

asympto & <35
Hypoglycemic neonate: how tx?
5% dextrose in WATER --> then feed breast/formula (prevent rebound hypogly) --> monitor until BG > 40 & stable

If no respond H2O --> IV dextrose
How define:

Microcephaly (what %s)
HC <10% for GA
Jaundice: accum bili in what skin layer?
Epiderm
Jaundice:

Occurs what % newborns?
60%
How does bilirubin travel in blood?
Binds ALBUMIN
Bilirubin:

Transported by albumin to what site?
LIVER
Bilirubin:

Conjugated in liver by WHAT ENZYME?
UDPGT
UDPGT: fxn?
Conjugates bilirubin (transported from blood to liver) with glucoronide
Bilirubin:

Conjugated to WHAT MOLECULE in liver?
glucoronide (via UDPGT)
Conjugated bilirubin is excreted into bile in WHAT FORM?
Stercobilirubin
Unconj (indirect) or Conj (direct):

Physiologic jaundice
Unconj
Unconj (indirect) or Conj (direct):

Breast milk jaundice
UNconj
Unconj (indirect) or Conj (direct):

Breast feed jaundice
Unconj
Unconj (indirect) or Conj (direct):

Direct Coombs jaundice
Unconj
Unconj (indirect) or Conj (direct):

Jaundice 2/2 spherocytosis
Unconj
Unconj (indirect) or Conj (direct):

PK deficiency
Unconj
Unconj (indirect) or Conj (direct):

Jaundice due G6PD
Unconj
Unconj (indirect) or Conj (direct):

Jaundice 2/2 cephalohematoma
Unconj
Unconj (indirect) or Conj (direct):

Jaundice 2/2 bruising
Unconj
Unconj (indirect) or Conj (direct):

Jaundice 2/2 swallowed blood
UNconj
Unconj (indirect) or Conj (direct):

Crigler-Naijjar
Unconj

(decreased bili clearance)
Unconj (indirect) or Conj (direct):

Galactosemia
Unconj

(decreased bili clearance)
Unconj (indirect) or Conj (direct):

Hypothyroid
Unconj

(decreased bili clearance)
Unconj (indirect) or Conj (direct):

Jaundice 2/2 neonatal asphyxia
Conj

(due liver ischemia)
Unconj (indirect) or Conj (direct):

Jaundice 2/2 sepsis
Conj

(liver isch)
Unconj (indirect) or Conj (direct):

Jaundice 2/2 congenital metabolic toxins
Cong

(liver isch)
Unconj (indirect) or Conj (direct):

Jaundice 2/2 biliary atresia, intestinal malrotation
COng
Physiologic jaundice:

-occurs in bili <___
-peaks what day? resolves what day?
Bili <15

Peaks d3-4 --> resolves d4-5
Physiologic jaundice: what 2 mxns?
Lack gut flora & increased activity beta-glucoronidase --> convert bili to unconj and reabsorb
Leads to what dz:

Neonate lacks gut flora & has increased beta-glucoronidase --> converts bili to unconj form --> reabsorbs
Physiologic jaundice (normal, benign)
How disting:

Physiologic vs. breast milk/feed jaundice?
Physio appears d0 --> peaks at d3 -- resolves d4

Breast: appears d4
Breast-milk/feed jaundice: underlying mxn?
INHIBITORY SUBSTANCE in milk --> increase enterohepatic circulation
Do RBC membrane defects (sphero) & enzyme defects (PK, G6PD) cause un/conj jaundice?
UNCONJ
3 etios of hepatobiliary dysfxn that can cause conjugated jaundice
Ischemia induced by: asphyxia, sepsis, congen metabolic toxins
Biliary atresia in neonate:

Absent INTRA or EXTRA hepatic bile ducts?
EITHER
Biliary atresia in neonate:

Assoc with what 2 other conditions?
Congenital HD

Intestinal malrotation
Biliary atresia in neonate:

If no tx --> what complication --> how long until die?
Develop cirrhosis --> die 2yo
Suspect what dz:

Neonate w/2 weeks of progressive jaundice
Biliary atresia
What dz:

Acholic stools, hepatomegaly, dark urine, increased alk phos
Biliary atresia (conj/direct jaundice)
Conj or Unconj jaundice:

See dark urine, acholic stools
DIRECT/CONJ
Biliary atresia in neonate: assoc w/elevation of which LFT?
ALK PHOS
Biliary atresia of neonate: possible to see increase in INDIRECT BILIRUBIN?
NO -- ALWAYS SEE INCREASED DIRECT BILI
Affect risk of severe hyperbili in newborn?:

-jaundice at d0-1
Earlier jaundice --> higher risk of severe hyperbili
What GESTATIONAL AGE:

highest risk of severe hyperbilirubinemia
35-38!!!
Jaundice: increased risk:

Breast or formula
Breast
Jaundice: increased risk:

M or F?
Male
Jaundice: increased risk:

White or Asian?
Asian (esp East Asian)
Jaundice: increased risk:

young or old mom
>25yo mom
Require further w/u?

Neonatal jaundice + VOMIT
Yes
Require further w/u?

Neonatal jaundice + fever
Yes
Require further w/u?

Neonatal jaundice + ONSET AFTER D3
YES
Require further w/u?

Neonatal jaundice + high-pitched cry
YES
Require further w/u?

Neonatal jaundice + bili <15
NO - suspect physio
Jaundiced neonate:

Does normal CBC rule out hemolytic dz?
NO ---- order retic to check for anemia
Breast milk:

Contain growth factors?
Yes
#1 carbohydrate in breast milk
Lactose
See lactose intolerance in neonates?
Uncommon 0-1yo
Breast milk:

Fats comprise what % calories? Most fat at beginning or end of feed?
50%

Most fat at end (encourage baby to drain boob)
Breast milk:

Contains what 2 proteins?
Whey
Casein
Breast milk:

More or less protein than cowmilk?
3x cow > breast
Do not give regular milk until what age?
>1yo
Colostrum: produced which days? slowly or rapidly replaced by milk?
d0-5

Slowly replaced by milk
Which has more: colostrum or breastmilk:

-minerals
-protein
-fats
-carbs
-IgA
Minerals: col
Protein: COLOSTRUM

Fat: milk
Carb: milk
IgA: milk
Breast-feeding: affect incidence of:

-SIDS?
-Allergies?
-DM?
Breast --> decrease incidence all
Should mother expect menses while breastfeeding?
NO - no ovulate
Breast-feed: increase or decrease risk breast cancer in mother? ovarian cancer? osteoporosis?
Decrease all

(since suppresses estrogen)
Breastfeed:

Is it common for infant to fall asleep before finish feed?
YES
Breastfeed:

How many feeds per day? How frequently? How many minutes each breast?
8-12 feeds/day
Every 2-3h
15mins/breast
Breast milk contains all vitamins EXCEPT _____
Vitamin K
Do breast-fed babies req suppl Vitamin D?
Only if <15 min sun /week
Fluoride: supplement at what age? Under what conditions?
Suppl all infants >6mos if <0.3ppm
Kernicterus: stain what structures?
Basal ganglia & hippocampus
Kernicterus: highest risk if 1st or subsequent episode of jaundice?
Highest risk if FIRST episode of jaundice
Bilirubin encephalopathy:

see HYPO or HYPERtonia?
TRICK

Hypotonia early --> hypertonia late
What dz:

yellow baby with hypotonia, vomit --> hypertonia, szs, ataxia
Bilirubin encephalopathy
Bilirubin encephalopathy: early OR late?:

Hypotonia
Early
Bilirubin encephalopathy: early OR late?:

Hypertonia
Late
Bilirubin encephalopathy: early OR late?:

Opisthotonous
Late
Bilirubin encephalopathy: early OR late?:

Szs
Late
Bilirubin encephalopathy: early OR late?:

Deafness
Late
Bilirubin encephalopathy: increased risk in whites or Asians?
Asians
Bilirubin encephalopathy:

Assoc w/prematurity?
Increased risk if premature
Bilirubin encephalopathy:

Assoc w/altitude?
Increase risk at high alt
Bilirubin encephalopathy:

What other medical problem is a risk factor?
Small bowel obstruction
How tx:

Breast + jaundice + bili 16-25
Cont breast + observe

OR

Suppl formula 24-48h + phototx
How tx:

Term + jaundice + hemolysis + bili 17.5-23
Exchange transfusion
Can you administer phototx while breast-feeding?
YES
Neonate w/hyperbili: can you lower via admin H2O/dextrose?
NO
Neonate:

What day stop meconium --> yellow BM
day 3
Neonate: what day:

3-4 stools/day
By d3-4
By d3-4 life: how many stools per day? how many wet diapers?
3-4 stools

3-4 wet diapers
By d6 life: how many stools per day? how many wet diapers?
3-4 stools

6 diapers
Return to birth weight at what age?
2w
At d5 life:

-at what % of birthweight?
-require w/u at what %?
At d5: 7-10% below birthweight

If >10% or no regain bw by w2 --> further w/u
How obtain FONTANELLE SIZE?
Avg length & width
Anterior fontanelle:

-suspect what problem if barely open at birth?
-what is avg diam?
Over-riding sutures (benign; separates w/in few days)

Avg: 2.5 - 5.0 cm
Name for:

Edema/serum over presenting part of scalp
Caput succedaneum
Caput succedaneum: where located?
PRESENTING part of scalp (=edema)
Caput succedaneum:

Leads to hyperbili?
NO -- overlies periosteum
Anatomic difference b/w:

Caput succedaneum & cephalohematoma
Caput: edema overlies periosteum --> NOT increase bili

Cephalo: SUBperiosteal hemorr (not extend suture line) --> can cause hyperbili
Cephalohematoma:

-where located in re: periosteum
-cross suture lines?
SUBperiosteal

NOT cross suture lines
Can you approximate the bilirubin level based on the extent of jaundice?
YES
Normal amount of breast tissue (mm) in term infant
5-6mm
Suspect what problem:

Neonate 0-72h & anorexia/vomit/sz
Inborn error of metab
What fraction of sick, full-term neonates without infection risks have an underlying metabolic dz?
20% !!! (1/5) --- that's a lot
Inborn error of metabolism: can appear insidiously?
Yes
Neonate screen: all states screen what 2 dzs? What method?
PKU
Hypothyroid

via tandem mass spec
Red reflux: see from how far away?
1 foot
Spleen: normally how far below L costal? Should you push to find tip?
1-2 CENTIMETER below L costal

Never push to find tip
Ortolani & Barlow: 1st perform at what age?
BIRTH
Developmental Dysplasia of Hip:

More common L or R?
3x L > R
Developmental Dysplasia of Hip:

F or M?
White or black?
F
White
Developmental Dysplasia of Hip:

Assoc w/birth position?
More common BREECH
Developmental Dysplasia of Hip:

Genetic component?
Higher risk if FHx DDH
Neonate phys exam:

Perform hip exam at what ages? (to assess DDH)
0-3mos
What test:

Thumb on lesser trochanter --> flex hip --> downward pressure
Barlow Test
Barlow test:

-where is thumb?
-flex or extend hip? what degree?
-ab/duct?
Thumb on LESSER trochanter --> flex to 90 --> ADDuct & down
What test:

Abduct hip & push femoral head anteriorly
Ortolani
Ortolani maneuver:

-ab/duct hip?
-push fem head ant or post?
ABDUCT (contrast Barlow - adduct)

Push fem head ANTERIORLY over greater troch
Barlow or Ortolani:

Feel CLUNK
Ortolani
T/F Every IUGR infant is SGA

T/F Every SGA infant was IUGR
T: every IUGR --> SGA

F: SGA may be 2/2 ethnicity, maternal ht, etc (not necessarily IUGR)
IUGR: poor wt gain in which TM is a risk factor?
TM3
IUGR: due to fetal abns?
Possible; can see with chromo abns, metabolic dz, congen infxn
What is safe amt of EtOH in preg?
NO SAFE AMT
Smoking --> what facial abns?
none

just low bw
How does cocaine/stimulant affect birth weight? (mxn)
Vasocon --> placental insuff --> low bw
What drug:

s/e fetal hydantoin syndrome
Phenytoin

(see in 30% exposed infants)
Phenytoin: safe in preg? safe in breastfeed?
S/E Fetal Hydantoin Synd (30% exposed fetuses)

SAFE IN BREAST FEED
Suspect what etiology:

Neonate with: hypoplastic nails & distal phalanges, cardiac defects, cranio deforms, IUGR, M.R.
Phenytoin --> fetal hydantoin syndrome
Higher risk in young or old moms:

-GHTN
-Preeclampsia
ADOLESCENT moms

--> low birth wt neonates
What is most ominous finding of respiratory distress?
PARADOXICAL BREATHING
Paradoxical breathing: see what? indicates what condition?
Inspire --> chest draws inward

See in resp distress
Name for sound:

Forced expiration against a closed glottis
Grunting
Grunting: due to what action?
Forced EXPIRATION against closed glottis
Grunting: see in what 3 lung dzs?
1. Atelectasis
2. PNA
3. Pulm edema
Head-bobbing in resp distress: synchronized with INSP or EXP?
INSP
Name for resp sound:

musical, CONSTANT PITCH, loudest at neck
STRIDOR
Stridor:

-constant or variable pitch?
-where ausc loudest?
-lower or upper aw?
Constant pitch (musical)
Loudest at neck
Upper aw
Stridor: see with insp, exp or both?
INSP ONLY

(according to CLIPP)
Difference between:

Wheeze vs. rhonchi
Basically same mxn

Wheeze: high pitch
Rhonci: low
Wheeze/rhonchi:

-due to RESONANCE?
-see w/insp, exp or both?
-where loudest?
NOT due resonance; due to VIBRATION of narrowed aws

EXP (or exp+insp; never insp alone)

loudest at chest
What resp sound:

Only here during EXP or EXP+INSP (never insp alone)
Wheeze/rhonchi
Wheeze/rhonchi: does longer & higher pitch indicate more severe dz?
YES
Crackles: dis/continuous?
DISCON
Crackles: sound differences b/w coarse & fine
Coarse: low pitch, loud, few

Fine: high pitch, quiet, many
Lower or upper aw obstrution:

Wheeze
Lower
Lower or upper aw obstrution:

Prolonged expiratory phase
Lower
Lower or upper aw obstrution:

VIRAL URI
LOWER!!!!

(see wet cough, no wheeze)
Viral URI: common to see wheeze?
NO
Asthma: is wheeze severity correlated with asthma severity?
NO

If severe asthma with no air exchange --> no wheeze (BEWARE)
Severe asthma --> what CV change?
Pulsus paradox
What dz: CXR shows:

Bilat hyperinflation, flat diaphs, atelectasis
Asthma
Lower or upper aw obstrution:

Acute bronchiolitis
LOWER

Edema/mucuus --> obstruct bronchioles
Lower or upper aw obstrution:

Pertussis
LOWER
Acute bronchiolitis:

What % due RSV?
50%
Acute bronchiolitis:

In addition to RSV - what other viruses?
para/influ
Acute bronchiolitis:

See what temps? (#)
38.5 - 39
Acute bronchiolitis:

See wheezing?
YES

(contrast VIRAL URI)
Acute bronchiolitis:

How appear CXR?
Bilat hyperinflat (sim asthma) w/scattered atelect
Asthma: due inflamm/edema of mucosa or parenchyma?
Mucosa

(contrast PNA - parenchyma)
Pneumonia: what BACTERIAL pathogen:

-5-6yo (#1)
-school age (#1-2)
5-6yo: Strep pneumo

School: MYCOPLASMA #1, Strep pneumo #2
Viral pneumonia: what 4 viruses common?
RSV, para/influ, adeno
Indicates what dz:

Crackles
PNA (bact or viral)
Chlamydia trachomatis PNA: presents how long after birth?
3-4w
Whooping cough: what pathogen?
Bordatella pertussis
Bordatella pertussis: vaccine is how effective? (%)
70-90%
What pathogen/dz:

3 stages (catarrhal, paroxysmal, convalescent)
Bordatella pertussis
Bordatella pertussis: 3 stages & duration of each
1. Catarrhal: 1-2w (URI sxs)
2. Paroxysmal: 4-6w (staccato)
3. Convalescent: mos cough
What dz:

Staccato cough
Bordatella pertussis (whooping)
Bordatella pertussis: cough may persist how long?
Paroxysmal cough 4-6w --> regular cough for mos
Lower or upper aw obstruct:

Foreign body
Upper
Lower or upper aw obstruct:

Epiglottitis
Upper
What dz:

Assymetic wheeze in 5yo w/out hx aw dz
foreign body
Foreign body asp: most common location
R mainstem bronchus
Epiglottitis: what age group?
2-5yo
Lower or upper aw obstruct:

Croup
TRICK - both (subglottic)
Croup: caused by 6 pathogens
Para/influ
Adeno
RSV

MYCOPLASMA
MEASLES!!!!
Indicates what dz (general name):

Insp stridor + barking cough
Croup
Cerebral palsy:

incidence
2:1,000
Cerebral palsy:

Progressive?
No
Cerebral palsy:

Defining feature
Decreaesed motor control
Cerebral palsy: is spasticity dependent on velocity?
YES - greater resistance w/rapid movement
Cerebral palsy: is resistance greater with SLOW or RAPID movement?
RAPID
Cerebral palsy: in/decreased tendon jerks
INCREASED
What dz:

See spastic diplegia
C.P.
Name for:

Increased tone, esp in lower extrems
Spastic diplegia
Spastic diplegia: assoc w/prematurity?
Yes
Leads to what TYPE of cerebral palsy:

-birth asphyxia
-kernicterus
Both lead ot DYSKINETIC cerebral palsy

(NOT other types)
Cerebral palsy: see pts with GLOBAL developmental delay?
No - just motor

GDD = cogn disabl/MR
MR/cognitive disability: possible to see FHx?
Yes - if 2/2 inborn error metab
Abn development 2/2 neglect:

See improvement if stop abuse?
YES
Do premature babies have increased risk of abuse?
Yes
Myopathy: p/w gross or fine motor abns?
BOTH
What class of dz:

abn tone, fasciculations, weakness
Myopathy

(NOT CP - see spasticity, increased tendon jerks)
Cerebral palsy: how dx?
MRI & assessment by developmental specialist (use Bayley scales of infant development)

(determines etio of abn neuro exam)
Infant UTI: how obtain urine sample?
CATH

(NOT bag specimen)
Fever: #
100.5 (38)
Name for:

Viable bacteria in circulation
Bacteremia

(no necess systemic dz)
Name for:

Systemic dz 2/2 microorgs in circ
Septicemia
Difference b/w:

Fever w/out source AND fever unknown origin
W/out source: no focus despite H&P

Unknown origin: 2weeks fever with 1w failed w/u
Fever of unknown origin: present for how long?
2w

(with 1w of failed w/u)
Occult bacteremia: definition (what tests)
Pos blood cx despite normal:
1. CXR
2. UA
3. LP
Occult bacteremia: see in what age range?
0-3yo
Qualify as SERIOUS bacterial illness (SBI)?:

Enteritis
Yes
Qualify as SERIOUS bacterial illness (SBI)?:

PNA
Yes
Qualify as SERIOUS bacterial illness (SBI)?:

Cellulitis
Yes
Qualify as SERIOUS bacterial illness (SBI)?:

Osteomyelitis
Yes
Qualify as SERIOUS bacterial illness (SBI)?:

Otitis Media
No
Meningismus: due to stretching of nerves in what SPACE?
Subarachnoid
Nuchal rigidity: in/vol?
INVOL
Name for:

Extreme nuchal rigidity --> hyperextend entire spine
Opisthotonus
What is it?:

Opisthotonus
Extreme nuchal rigidity --> hyperextend entire spine
Name for:

flex hip & extend knee --> pt resists knee extens
Kernig
Name for:

flex neck --> pt flexes knee & hip
Brudzinski
Difference b/w:

Kernig
Brudzinski
Kernig: flex hip --> resist knee EXTENSION

Brud: flex neck --> automatic flex knee & hip
If you plan to tx infant w/IV abx for presumed bacterial infxn --> do you require a LP?
YES - RULE

If want to use IV abx --> get LP first
LP contraindication: platelets <___ (#)
<50k
Must perform LP if fever <__ (what age)?
1yo
Does normal CSF definitively r/o meningitis?
YES
Febrile infant:

Suspect UTI in what ages?
2mo - 2yo
Gastroenteritis: see low or high fever with:

-viral
-bact
HIGH FEVER with both
Upper resp infxn: see low or high fever?
Can see high fever
Work-up of BACTERIAL infxn: low or high predictive value:

>15,000 WBC w/left ****
LOW predictive value
Viral infection: do most have ab/normal WBC?
Most have NORMAL
UA: nitrites have high or low:

-spec
-sens
HIGH SPEC (few FPs)

LOW SENS (many FNs)
UA: is a positive LE enough to dx UTI?
No - only indicates that WBCs are in urine
Voiding cysturethrogram (VCUG): order in which infants?
ALL infants w/FIRST uti
VUR: is most mild/mod/severe? req tx?
Most mild --> spont resolve
UTI in <1yo:

what % have vesicourethral reflux?
50%
VUR: affect risk of UTI? req ppx abx?
Increase risk of UTI --> GIVE PPX ABX (until VUR resolves or surg)
VUR: what is alt way to monitor (if not want VCUG)?
Periodic radionuclide cystograms
1st UTI --> order what imaging tests?
1. VCUG
2. Abdominal U/S (renal structure, dilation)
UTI in infant:

-required in ALL cases?
-duration?
-route?
-repeat urine cx?
ALL pts w/1st UTI (even if asympto)
7-14d
po --> IV if severe dehydr

Repeat urine cx if no response after 2d
Pyelo: 2 most common pathogens
E coli > enterococcus
Pyelo:

-2 best abx & route for INPATIENT
-outpatient
Gent + Amp INTRAVENOUS

-->

TMP-SMZ bid (total 7-14d)
Pyelo: what is disadvantage of:

-Ceftriaxone
-Ciprofloxacin
Ceftriax: no cover enterococci (#2), pseudomonas

Cipro: damages articular cartilage (esp knees)
Nitrofurantoin: use in what type of UTI?
Lower UTI (cystitis)

NOT pyelo
Sulfisoxazole: used to tx pyelo?
No - resistance
Always consider what dz:

HIGH fever x 5d....
Kawasaki
Always consider what dz:

HIGH fever x 5d....
Kawasaki
Kawasaki: usually <___yo
<4yo
Kawasaki: requires how many findings?
4 (in addition to fever)
Kawasaki: usually <___yo
<4yo
3 dzs with palmar rash
Kawasaki
Syphilis
RMSF
Kawasaki: requires how many findings?
4 (in addition to fever)
Kawasaki: where see rash (2)?
Groin
PALMS
3 dzs with palmar rash
Kawasaki
Syphilis
RMSF
Kawasaki: what 2 eye findings?
1. Conjuncitivitis w/out discharge
2. ANTERIOR uveitis (slit lamp)
Kawasaki: where see rash (2)?
Groin
PALMS
Anterior uveitis 2/2 Kawasaki:

-how detect (what test)?
-minority or majority of pts?
Slit-lamp

80% pts in 1st week
Kawasaki: what 2 eye findings?
1. Conjuncitivitis w/out discharge
2. ANTERIOR uveitis (slit lamp)
Strawberry tongue: what 3 dz?
1. Kawasaki
2. Strep pharyngitis
3. Infectious mono
Anterior uveitis 2/2 Kawasaki:

-how detect (what test)?
-minority or majority of pts?
Slit-lamp

80% pts in 1st week
Strawberry tongue: what 3 dz?
1. Kawasaki
2. Strep pharyngitis
3. Infectious mono
Kawasaki: see LAD?
YES
Kawasaki: see LAD?
YES
What dz:

HIGH FEVER x5d, groin rash, conjuncitivitis, strawberry tongue, puffy/peeling hands & feet
Kawasaki
What dz:

HIGH FEVER x5d, groin rash, conjuncitivitis, strawberry tongue, puffy/peeling hands & feet
Kawasaki
Kawasaki: low or high fever?
HIGH x 5d
4 causes of UNILATERAL cervical adenitis (non-cancerous)
1. Kawasaki
2. Cat Scratch
3. Pharyngeal infection --> reactive node
4. Mycobacteria
Kawasaki: see uni/bilat LAD?
UNILAT
SJS:

-see conjuncitivitis?
-what type of rash (name)?
Conjunctivitis

Erythema multiform
#1 fatal tick dz
RMSF
RMSF: how transmit?
Tick
RMSF: what type of rash? where located?
Petichial rash on palms
What dz:

Petechial rash, HEADACHE, fever, myalgia
RMSF
Kawasaki: see change in CBC?
1. INCREASE WBC, esp PMNs

2. Normocytic, normochromic anemia

3. Increase platelets (week 2)
Kawasaki: would you still suspect if negative ESR?
no
Kawasaki: see changes in LFTs?
INCREASE (nonspecific)

decrease albumin
Suspect what dz:

Increased WBC (esp PMNs), normo normo anemia, increased platelets, increased LFTs, STERILE PYURIA
Kawasaki
Kawasaki: what UA change? how collect UA?
STERILE PYURIA (2/2 sterile urethritis)

Collect via CLEAN CATCH (would not detect pyuria by cath)
Kawasaki: order what imaging test?
Baseline ECHO --> repeat ECHO 4 weeks
Kawasaki: how tx? (2)
HIGH-dose ASA (other antipyretics not effective)

HIGH-dose intravenous Ig (only tx ot decrease coronary art sequel)
Kawasaki: see CNS complications in what % pts?
90%: lethargy, aseptic meningitis
Kawasaki: see coronary art aneurysm in what % untx pts?
25%
Kawasaki: what GI complication? (2)
Liver dysfxn (40%)

Gallbladder hydrops (10%)
Kawasaki: after discharge --> when RTC for repeat ECHO?
Echo at weeks 0 & 4

(usually RTC 2 weeks after discharge for repeat)
What pathogen:

Vesicular rash on hands & feet; ulcers in mouth
COXSACKIE (enterovirus) --> hand-foot-mouth dz
What pathogen:

Hand-foot-mouth dz
Coxsackie (enterovirus)
What pathogen:

Prodrome fever >101 --> cough, runny nose, conjunctivitis --> maculopap rash behind ears --> reaches feet
MEASLES

3Cs
Measles: describe rash lesions & distrib
Maculopap

Starts behinds ears --> reaches feet w/in 2 days
Meningococcal rash: itchy?
YES
What pathogen:

High fever 3d --> fever ends --> rash on trunk --> spreads arms, neck
Rubeola
Rubeola: which see first:

Rash or fever
Fever --> fever ends --> trunk rash
Rubeola: describe rash lesions & distrib
Maculopap on trunk --> spreads arms/neck

**Fever ends before rash appears
Rubeola: usu <__yo
<2yo
Strep pharyngitis (GAS): 2 systemic comps
1. Scarlet fever (blanching sandpaper)

2. Rheum heart disease
What pathogen:

Blanching sandpaper rash & high fever
Strep pharyngitis --> Scarlet fever
Scarlet fever: low or high fever?
HIgh
Scarlet fever: describe rash
blanching sandpaper

starts groin/ax/neck --> spreads
Scarlet fever: rash resolves how long?
<10d
Rheumatic fever: develops how long after strep infection?
18 days
What disease?:

Jones Criteria
Rheumatic fever
Rheumatic fever: was diagnostic criteria (eponym)? req how many (#) criteria?
Jones criteria

1 major + 2 minor
2 major + 1 mintor
What dz:

Migratory polyarthritis, peri/myocarditis, erythema marginatum, subQ nodules & chorea
Rheumatic fever (2/2 strep pharyngitis)
Rheumatic Fever:

-what type of arthritis?
-name for classic rash
-what neuro disorder
MIGRATORY polyarth

Erythema marginatum

Sydenham's chorea
Rheumatic Fever: what EKG finding?
Prolonged PR
What viral exanthem:

EKG - prolonged PR
Rheumatic Fever
What dz:

Complication: peritonsilar abscess
Strep pharyngitis
VZV: starts where on body?
Trunk
VZV: resolves after how long?
1 week
What dz:

Upslanted palpebral fissures
Downs
What dz:

-small ears
-low-set ears
Small: Downs

Low: Turner's
What dz:

Epicanthal folds
Downs
What dz:

Redundant nuchal skin
Downs
#1 M.R. involving genetic material
Downs (21)
Down's: 3 genetic mxns
Trisomy (#1, regardless mat age)

Unbalanced translocation

Mosaic for 21
Down's: ABSOLUTE risk higher in young or old mothers?
YOUNG

(relative risk higher in old)
Downs: how dx?
Leukocyte karyotype
What dz:

Micropthalmia, microceph, polydact, cleft lip & palate, umbilical hernia, CUTIS APLASIA
Patau (13)
Patau (13): defects in what organs? (2)
Cardiac
Renal

Also: microceph, polydact, clefts, umbilical hernia, cutis aplasia
#1 FAMILIAL cause of M.R.
Fragile X
Fragile X: what repeat?
CGG outside FMR1 coding regions
What dz:

larges testes; large everted ears; long face w/large mandible
Fragile X
Turner's syndrome: see physical differences at birth?
Yes
What dz:

See lymphedema in utero
Turner XO
What dz:

web neck, low ears, hyperconvex nails, shield chest
Turner XO
Turners:

What is feature of nails?
Hyperconvex
Turners:

Ao coarctation in what %?
20%
Turners:

How affect IQ?
NORMAL IQ
How dx:

Benign Neonatal Hypotonia
Dx of EXCLUSION
Benign Neonatal Hypotonia: px?
Good; gradual increase tone
Down's: what is most consistent finding at birth?
HYPOTONIA --> poor feeding
Down's: recommended imaging at birth?
ECHO
Down's: recommended blood test?
TSH

(6mo --> q 1 year)
Down's: what skeletal abn?
Atlanto-axial instab
Down's: predisp what cancer?
Leukemia
Hypotonia in infant:

Tend to FLEX or EXTEND extrems?
Extend (passive)

(noxious stim --> won't flex)
Hypotonia in infant: see in/decreased primitive reflexes?
DECREASED

(since hypotonic)
Hypoxic-ischemic encephalopathy 2/2 perinatal injury:

more commonly see HYPO or HYPERtonia?
HYPER

(although can see hypo)
Suspect what dz:

Normal neonate --> 2-4w later see lethargy, fever, HYPOTONIA
SEPSIS 2/2 GBS
Congenital hypothyroidism: how affect ammonia level?
No change (normal NH4)
Newborn metabolic screen: uses what lab technique?
Mass spec
Screens for what dz:

Measure immunoreactive trypsinogen
Cystic fibrosis
How define:

Lethargy
1. Decreased eye movements

OR

2. fail to recog parents or interact w/environ
Name for:

Decreased eye movements & fail to interact w/parents or environ
LETHARGY
How define:

FTT
Fail to regain bw by 3 WEEKS or continuous wt loss after 10d life
#1 sudden death adol athlete
Hypertrophic Obstructive Cardiomyopathy (HCOM)
Hypertrophic Obstructive Cardiomyopathy (HCOM):

-p/w what sx?
-what % have abn EKG?
SYNCOPE

90% abn EKG
Child w/chest pain: higher suspicion of cardiac etio if:

present at rest OR exercise only?
Exercise only
Chest pain due myocardial ischemia:

-sharp or dull?
-how long last?
Dull pressure
10-20 mins
What dz:

Sharp/stabbing chest pain REPRODUCIBLE w/direct sternal pressure
Costochondritis
Costochondritis: how long does pain last?
few seconds of stabbing over hrs-days
Costochondritis: chest pain assoc w/exercise?
NO - sporadic
What is dz:

Chest pain worse with deep inspiration
Costochondritis
Costochondritis: worse with insp or exp?
Deep insp
Which more common:

Precordial catch OR costochondritis
Precordial catch
#1 chest pain in child
Precordial catch
Precordial catch: assoc w/exercise?
No

(occurs equally at rest or exercise)
Precordial catch:

-diffuse or well-localized? where most common?
-sharp or dull?
sharp, well-localized at LOWER STERNAL BORDER
Precordial catch: how long pain last?
secs-mins
Precordial catch: worse w/insp or exp?
Deep insp

(same as costochondritis)
What dz:

Chest pain that pt can BREAK with forced deep insp
Precordial catch
Name for:

Inadeq cerebral BF --> transient LOC & loss of postural tone
Syncope
Syncope: underlying mxn?
Decreased cerebral BF
3 general etios of syncope in child
1. Neurocardiogenic (vasovagal; #1)
2. Neuropsych (szs, orthostatic, drugs)
3. Cardiac (arryth, structure defect)
Syncope 2/2 orthostatic hypotension: classify as NEUROPSYCHIATRIC or CARDIOGENIC?
Neuropsychiatric
What drug class:

S/E prolonged QT --> neuropsychiatric syncope
Antihistamines
Antihistamines: S/E what EKG change?
Prolonged QT
Difference b/w 1' and 2' cardiac syncope
1': structural defect --> obstruct ventricular outflow

2': ventricle DYSFXN or ARRYTH
3 types of arryths that can cause syncope
1. SVT
2. VT
3. Heart block (2/2 Lyme)
Syncope in child: EKG which pts?
ALL
Syncope in child: which is more serious:

Pallor OR warm/flushed skin
WARM/FLUSHED
Syncope during exercise: mandatory refer to cardio?
YES
Are murmurs COMMON in healthy adols?
Yes
Teen physical:

Palp which 2 pulses?
Femoral
Radial

--> assess Ao coarct
HCM: murmur louder supine OR standing?
STANDING
Murmur: evaluate if louder than ___ (what grade?)
III/IV
Teen physical:

How long should orthopedic exam take?
2min
Teen physical:

Require chaperone for GU?
always
What Tanner Stage:

Testes <1.5 mL
1
What Tanner Stage:

No pubes
1
What Tanner Stage:

Testes 1.6 - 6 mL
2
What Tanner Stage:

Red, thin scrotum
2
What Tanner Stage:

Thin pubes at base of penis
2
What Tanner Stage:

Testes 6-12 mL
3
What Tanner Stage:

Curly, coarse hair
3
What Tanner Stage:

Testes 12-20
4
What Tanner Stage:

Darken & increase size of scrotum
4
What Tanner Stage:

Adult pubes but absent on thighs
4
What Tanner Stage:

>20 ml testes
5
What Tanner Stage:

Pubes on medial thighs
5
What is difference and which most common:

1' vs. 2' vs. 3' hypothyroidism
1': thyroid dysfxn (95%)
2: pit
3: hypothal
Congenital hypothyroidism: most common what ethnicities? (2)
Native Am
Hisp
Mxns of congenital 1' hypothyroidism
Thyroid ectopy
A/hypoplasia
Errors of thyroid hormogenesis
1' hypothyroidism: low or high TSH?
HIGH

(HPA intact; prob is thyroid)
1' or 2/3' hypothyroidism:

Low TSH
2/3 (pit/hypothal not producing TSH --> low T4)
Does maternal thyroid hormone cross placenta?
YES

Infant with congenital hypothyroid appears normal at birth due maternal thyroid
Congenital hypothyroidism: when do s/sx present?
6 WEEKS OF AGE
Congenital hypothyroidism:

Constip or diarrhea?
Constip
Congenital hypothyroidism:

How does skin appear?
JAUNDICED, mottling
Congenital hypothyroidism:

Small or large fontanelles
LARGE
Congenital hypothyroidism:

Hypo or hypertonia
HYPO
Congenital hypothyroidism:

Hypo or hyperthermia
Hypo
Congenital hypothyroidism:

What abdominal defect?
Umbilical hernia
Infant hypo or hyperthyroidism:

See umbilical hernia
Hypo
What dz:

Normal neonate --> 6w age p/w feeding probs, jaundice, large fontanelle, hypotonia --> large tongue, puffy myxedematous face & M.R.
congenital hypothyroid
What is next step:

Newborn screen shows low T4, high TSH --> ?
START L-THYROXINE

then resend blood to confirm (do NOT wait to start tx)
Congenital hypothyroid: initiate L-thyroxine --> what is goal TSH? T4?
TSH: 1 mU/ml

T4: upper 1/2 normal
Congen hypothyroid: measure T4/TSH how often?
2w --> 4w --> q1-2 mos until 1yo --> q2-3mos until 3yo --> q3-12 mos until complete growth
#1 etio ambiguous female genitalia
Congen Adrenal Hyperplasia
Congen Adrenal Hyperplasia: how inherit (pattern)?
AR
Congen Adrenal Hyperplasia: defect what hormone?
Cortisol synth
Congen Adrenal Hyperplasia: #1 type
21-OH deficiency

Decrease cortisol, aldo

Increase 17-OH progest --> increase androgens
21-OH deficiency:

-decrease production which hormones? (2)
-increase production which hormone? effect?
Decrease cortisol, aldo

Increase 17-OH progest --> increase androgens --> verilize fems
Difference b/w:

CLASSIC and NONCLASSIC congen adrenal hyperplasia
Classic: complete enz def --> adrenal crisis --> hypoNa, hyperK --> shock at 1-2w

Nonclassic: NON-VIRILIZING; partial enz def --> manifests under stress
Classic CAH: sxs appear what age?
1-2w
CAH: what lyte abns? (2)
HypoNa+

HyperK+
Non-classic CAH: virilizing?
NO

partial enz def --> manifests under stress
See proteinuria with:

-acute glomerulonephritis?
-intersitital nephritis?
YES BOTH - but not as high as nephrotic syndrome
What dz:

1+/2+ protein during FEVER or EXERCISE
Benign proteinuria
Benign proteinuria: how define?
1+/2+ protein during fever or s/p exercise
What dz:

Only excrete protein when standing (1,500mg/d)
Orthostatic proteinuria
Orthostatic proteinuria: indicate renal dz?
NO - common in adols
Orthostatic proteinuria: see in AM?
NO - first AM urine should be negative since lying down --> not spillling protein
Common to see generalized tonic-clonic szs in newborn?
NO - contrast older infants
Neonatal sz: see horizontal or vertical deviation?
Horiz
Suspect what phenomenon:

Neonate w/eye jerking, lip-smacking, tonic limb posturing, APNEA
SEIZURE

(subtle s/sx)
Ankle clonus: what is normal # beats?
<10
Clonus: what is abn # beats in a 1-2mo old?
>3 beats is abnormal
Indicates what process:

-schistocytes
-helmets
Hemolysis (both)
If atopic parent --> what is risk to child? (%)
30% risk
Has rate of asthma increased in recent years?
2x increase in 15 years
#1 chronic dz in peds
asthma
Asthma: how long last & what cells involved:

-early rxn
-late rxn
Early (0-1h): masts & eosinos --> increase perm/mucus & bronchocon

Late (2-3h later): eosino, PMN, leuko --> epi destruct & remodel SM
Asthma:

-how many hrs until late rxn peaks? resolves?
-how long does aw hyperresponsiveness persist after late rxn?
peaks 4-8h --> resolves 24h

aw hyperresponsive for days-wks
Asthma: wheeze in what part of resp?
End-exp
How do allergies --> chronic cough?
Allergy --> nasal congest --> PND --> noct cough
What dz:

COBBLESTONE post pharyxn
PND --> lymphoid hyperplasia
Allergic rhinitis: what TYPE of hypersens rxn?
Type 1 (immed)
Allergic rhinitis: how tx? (2)
Antihistamine
topical nasal steroids
Sinusitis: req sxs how long?
1week purulent nasal discharge
Sinusitis: see fever?
YES
Sinusitis: nose & throat swabs useful?
No
Sinusitis: 4 most common bact
S pneumo
H flu
M catar
Strep PYOGENES
Sinusitis: tx with what class?
B-LACTAMS
-cefuroxime
-augmentin
When develop:

-ethmoid sinuses
-max sinuses
-frontal
Ethmoid & max: at birth

Frontal: 6-8yo
Bronchitis: s/sx worse day or night?
EQUAL

(no change w/temp,exercise)
Think what dz:

Rhonchi
Bronchitis
Atypical/viral PNA: s/sx change w/temp, exercise?
MAY WORSEN

(contrast viral URI)
Atypical/viral PNA: expect cough for how long?
8-12w
How does GERD --> nasal congestion?
NASAL reflux --> congest
Habitual cough: what is initial trigger?
Viral URI
What dz:

Brassy, short, dry spasmodic cough; no change w/exercise, cold; resolves w/sleep
Habitual cough
Fungal pulm infxn: dry or wet?
DRY
Chlamydia PNA: intermittent or paroxysmal cough?
Parox!
Mycoplasma PNA: intermittent or paroxysmal cough?
Parox
Suspect what dz:

Chronic cough + palpitations
CHF
Suspect what dz:

Chronic cough + abdominal pain
PNA
Insp:Exp ratio:

-normal
-restrictive lung dz
-obstructive
I:E

Norm: 1:2
Restrict: 1:1
Obstruct: 1:3 (due air-trapping)
Due obstruction in small/med/large aw:

Wheeze
Mod
Due obstruction in small/med/large aw:

Rhonchi
Large
Due obstruction in small/med/large aw:

Rales
Small

(contrast rhonchi: large)
Difference between:

Variable & fixed obstruction
Variable: insp or exp ONLY

Fixed: BOTH insp & exp
If immunized child w/chronic cough --> suspect pertussis?
Unlikely
Fungal PNA:

-is cough productive? disturb sleep?
-chest pain?
Non-productive cough not disturb sleep

PLEURITIC chest pain
What type of cancer can present with chronic cough?
Mediastinal lymphoma
Child with 1' TB:

See what changes on CXR?
FEW/NO CHANGES

(little evidence of initial focus)

May see focal hyperinflat, atelect
Suspect what dz:

*Large regional lymphadenitis + non-productive cough + FTT + f/c
1' TB
Pediatric Tb: see small or large regional lymphadenitis?
LARGE
Pediatric TB: which lobar segments at increased risk?
EQUAL RISK

2+ foci in 25% pts
Pediatric TB: see local effusions on CXR?
YES
If suspect TB and pt is symptomatic --> how officially dx?
sputum cx OR 1st AM gastric asp

(positive PPD also useful in ped)
What size:

Positive PPD in low-risk child
>15mm
Asthma: how tx:

Mild intermittent
B-agonist
Asthma: how tx:

Daily persistent asthma
B-agon + inhaled cortico
Inhaled corticosteroid: how long until see improvement?
few weeks
Asthma: if LT inh corticosteroids --> monitor what 4 things?
1. BP (HTN)
2. BG
3. Growth
4. Cataracts
Asthma: does administration of leuko-synth inhibitor affect the req dose of inh steroid?
allows lower dose steroid
Asthma: which more effective:

Inh steroid or leuko-inh
STEROID
Asthma: can you use leuko-inh as monotherapy?
NO
If see CXR with mediastinal/hilar adenopathy --> think what 3 dzs?
1. TB
2. Fungal PNA
3. malig
Cystic fibrosis: restrictive or obstructive
Obstructive (mucus plug traps air)
Obstructive or restrictive:

Decrease FEV1/FVC
Obstruct
Asthma: decrease or normal FEV1/FVC
Decrease
Obstructive or restrictive:

SLE
Restrictive
Obstructive or restrictive:

Normal FEV1/FVC
Restrict
Nephrotic syndrome:

-what age?
-M or F?
1.5-8yo
M >F
Nephrotic syndrome:

#1 etio
MCD
Nephrotic syndrome:

Fluid moves from ___ to ____
Lose albumin in urine --->

Fluid moves from VASC to INTERSTITIUM --> hypovolemia
Nephrotic syndrome:

How affect BP?
NORMAL BP

Retain H2O but fluid moves out of vasc into interstitium
How affect BP:

-Nephrotic syndrome
-Acute glomerulonephritis
Nephrotic: normal BP

Acute GN: HTN
Acute glomerulonephritis: #1 presenting s/sx
Tea colored urine
Nephrotic synd and/or acute glomerulonephritis:

Gross hematuria
acute nephritis
Nephrotic synd and/or acute glomerulonephritis:

preceded by URI
acute nephritis
Nephrotic syndrome: what lyte change? 2 mxns for change
HYPONATREMIA

1. Lose vasc fluid to interstitium --> retain excess H2O & Na in kidney
2. HYPERLIPID --> pseudohyponatremia
Nephrotic syndrome: how affect cholesterol?
Lose albumin in urine --> Liver increases lipid production --> HYPERCHOLESTEROL

(also see decreased lipid clearance from circ)
Nephrotic synd:

Consider what imaging?
Renal U/S
Nephrotic synd: order C3/C4?
Yes - r/o collagen vasc dz
Nephrotic synd:

Order what test to r/o post-strep glomerular dz
Streptozyme
Nephrotic synd:

Tx w/albumin infusion in what 2 scenarios?
1. Ascites/effusion -->resp problems

2. Scrotal edema
Nephrotic synd:

Can you tx with diuretic monotherapy? How admin?
Albumin infusion --> THEN intravenous furesomide

*Never diuretic alone --> hypovol
Nephrotic synd:

Steroids useful?
Yes
Nephrotic synd:

How much salt per day?
restrict 1,500 - 2,000 mg daily
Nephrotic synd:

Admin what ppx vaccine
PCV
Nephrotic synd: what 2 drugs prevent relapse?
cyclophosphamide x 8-12w

Calcineurin inhibitor (tacro, cyclospor) x 2 years
Nephrotic synd:

See what complication (esp if tx with steroids)
Spontaneous peritonitis
Nephrotic synd:

Most common pathogen in spont peritonitis (comp)
Strep Pneumo

(also GNs)
Nephrotic synd:

Do minority or majority kids outgrow?
Majority
PID: what age?
15-19yo F
PID: G&C --> also infect uterus w/what 4 pathogens?
1. E coli
2. Bacteroids
3. Mycoplasma
4. Ureaplasa
What dz:

16yo F with suprapubic pain --> RUQ pain radiating to R shoulder
Fitz-Hugh-Curtis (2/2 PID)
PID: is pain most commonly uni/bilat?
BILAT
PID: order what tests?
Cervical cx
Urine PCR
PID: req to tx partners?
Yes
Low or high fever?:

Appendicitis
Low
Low or high fever?:

Acute cholecystitis
Low
Low or high fever?:

Pneumonia
HIgh
Low or high fever?:

UTI
High
Low or high fever?:

Septic cholangitis
HIgh

(contrast acute cholecystitis: low)
Low or high fever?:

Gyn infxn (e.g. PID)
High
Hypo-, normo- or hyperactive bowel sounds:

Ileus
Hypo
Hypo-, normo- or hyperactive bowel sounds:

Gastroenteritis
Hyper
Hypo-, normo- or hyperactive bowel sounds:

SBO
Hypo <--> high-pitched hyper (peristalsis)
What dz:

Bowel sounds: quiet --> high-pitched and hyper --> quiet
SBO w/peristalsis
Abd exam: what does hyperresonance indicate?
Gaseous distension
What dz:

Involuntary guarding
Peritonitis
Hepatitis:

-see vomit? diarrhea?
-fever?
-mandatory finding?
Vomit; no diarrhea
Fever
Usu see JAUNDICE
Hepatitis: well-localized or vague abd pain?
Vague (sometimes RUQ)
What dz:

Epigastric pain radiating to back
Pancreatitis
Pancreatitis:

-vomit?
-diarrhea?
Vomit yes
Diarrhea no

(same as hepatitis, appenditicits)
Appendicitis:

-vomit?
-diarrhea?
Vomit yes, diarrhea no

(same as hepatitis, pancreatitis)
Does sexual debut affect risk of UTI?
Yes - increased risk at debut
Low or high fever:

Ectopic pregnancy
TRICK - no fever
What dz:

Acute INTERMITTENT sharp abdominal pain radiating down extremitin; n/v
OVARIAN TORSION
Ovarian torsion: is pain intermittent or constant
INTERMITTENT
Ovarian torsion usually idiopathic or 2/2 cyst/neoplasm?
2/2 cyst/neoplasm
Ovarian torsion:

-vomit?
-diarrhea?
Vomit

no diarrhea
Ovarian torsion: see bilateral torsion?
See bilat in INFANT
Testicular torsion: what finding on phys exam?
Lose cremasteric
Testic torsion: irrevers damage after how long?
4h
Crohn's: 1st line drug
Mesalamine (5-ASA)
Mesalamine (5-ASA): 1st line in what dz?
Crohn's
Infliximab: what dz?
IBD
What dz:

Chronic abd pain + bloody stools + failure to grow
IBD
IBD: is pain localized?
YES (red flag)
IBD: does pt p/w urinary sxs?
DYSURIA
IBD: will pain awaken pt from sleep?
Yes
IBD: what % pts have positive FHx?
30%
IBD: what CBC abnormalities? (2)
Anemia
HIGH PLATELETS
IBD: see hypo or hyperalb?
Hypo
IgA tissue transglutinase Ab (TTG): sens? spec?
Sens & spec for celiac
Tissue transglutinase: what CLASS of Ab? (Ig_)
IgA
Celiac: un/common?
Uncommon
What dz:

6mo-2yo with chronic abd pain + ABDOMINAL DISTENSION + vomit/diarrhea + NO GROSS BLOODY STOOLS
Celiac dz
Celiac dz: what is youngest age you may see?
6mo!
Celiac: see gross blood loss? occult?
OCCULT --> anemia

(no gross BRBPR)
Peptic ulcer dz: common in child?
NO
Peptic ulcer: see diarrhea? gross bloody stool?
NO - p/w pain & occult loss
#1 intestinal PARASITE in US
Giardia
Giardia: best dx test?
SPECIFIC ANTIGEN TEST

(NOT O&P)
What dz:

Abdominal pain & palpable mass & bloody streaks on stool & guaic pos
Constipation
HSP:

-diarrhea?
NO

Although most pts p/w collicky pain & bloody stools
What dz:

Collicky abdominal pain + bloody stools + RASH + no diarrhea
HSP
HSP: abd pain is constant or intermittent?
COLLICKY
#1 etio chronic abdominal pain in child
Functional abd pain (dx of exclusion)
Functional abd pain: see bloody stool?
NO - if blood --> cannot be fxnl
Functional abd pain: how tx?
Reassurance
IBD: 1st imaging test to perform? 2nd? risks?
Colo --> THEN barium enema (delays colo)

UC: enema --> increase risk toxic megacolon
#1 intestinal PARASITE in US
Giardia
Giardia: best dx test?
SPECIFIC ANTIGEN TEST

(NOT O&P)
What dz:

Abdominal pain & palpable mass & bloody streaks on stool & guaic pos
Constipation
HSP:

-diarrhea?
NO

Although most pts p/w collicky pain & bloody stools
What dz:

Collicky abdominal pain + bloody stools + RASH + no diarrhea
HSP
HSP: abd pain is constant or intermittent?
COLLICKY
#1 etio chronic abdominal pain in child
Functional abd pain (dx of exclusion)
#1 intestinal PARASITE in US
Giardia
Functional abd pain: see bloody stool?
NO - if blood --> cannot be fxnl
Giardia: best dx test?
SPECIFIC ANTIGEN TEST

(NOT O&P)
Functional abd pain: how tx?
Reassurance
What dz:

Abdominal pain & palpable mass & bloody streaks on stool & guaic pos
Constipation
IBD: 1st imaging test to perform? 2nd? risks?
Colo --> THEN barium enema (delays colo)

UC: enema --> increase risk toxic megacolon
HSP:

-diarrhea?
NO

Although most pts p/w collicky pain & bloody stools
What dz:

Collicky abdominal pain + bloody stools + RASH + no diarrhea
HSP
HSP: abd pain is constant or intermittent?
COLLICKY
#1 etio chronic abdominal pain in child
Functional abd pain (dx of exclusion)
Functional abd pain: see bloody stool?
NO - if blood --> cannot be fxnl
Functional abd pain: how tx?
Reassurance
IBD: 1st imaging test to perform? 2nd? risks?
Colo --> THEN barium enema (delays colo)

UC: enema --> increase risk toxic megacolon
#1 intestinal PARASITE in US
Giardia
Giardia: best dx test?
SPECIFIC ANTIGEN TEST

(NOT O&P)
What dz:

Abdominal pain & palpable mass & bloody streaks on stool & guaic pos
Constipation
HSP:

-diarrhea?
NO

Although most pts p/w collicky pain & bloody stools
What dz:

Collicky abdominal pain + bloody stools + RASH + no diarrhea
HSP
HSP: abd pain is constant or intermittent?
COLLICKY
#1 etio chronic abdominal pain in child
Functional abd pain (dx of exclusion)
Functional abd pain: see bloody stool?
NO - if blood --> cannot be fxnl
Functional abd pain: how tx?
Reassurance
IBD: 1st imaging test to perform? 2nd? risks?
Colo --> THEN barium enema (delays colo)

UC: enema --> increase risk toxic megacolon
What dz:

Cobblestone mucosa of GI tract
Crohn's
What dz:

GI mucosa friable & erythematous
UC

(contrast Crohn's - cobblestone)
What dz:

GI PSEUDOPOLYPS
Ulcerative Collitis
CD or UC:

ALWAYS involves rectum
UC
Sickle cell:

-what AA substitution?
-which Hgb chain?
Switch VAL to GLUTAMIC ACID

Beta chain
Sickle cell:

De/increase retic count?
INCREASE retics
What electrophoresis pattern in:

-fetus --> normal adult
-sickle TRAIT
-SCD
Normal: FF --> AF

Trait: FSC (mild sickling)

Dz: FS
What dz: electrophoresis shows:

FSC
sickle TRAIT

(dz: FS)
What dz: electrophoresis shows:

FS
Sickle DISEASE

(trait: FSC)
Sickle cell:

-what is baseline color of pt?
-what does pallor indicate?
Baseline jaundice (2/2 hemolysis)

Pallor due: spleen sequestor RBCs and/or aplastic crisis
Sickle cell:

Murmur?
Flow murmur 2/2 anemia
Sickle cell:

Is parental monitoring of spleen effective ppx?
YES
Sickle cell:

How evaluate for stroke? (what test)
Transcranial Doppler
Sickle cell:

What UA finding?
Hematuria 2/2 papillary necrosis
#1 death in sickle pts
Acute chest synd
What dz:

Sickle pt with fever, cough, SOB, hypoxia
Acute chest syndrome
Acute chest syndrome:

Single or multiple lobules affected?
Multilobular
Acute chest syndrome:

How appear CXR?
NEW INFILTRATES; effusion, atelectasis
Acute chest syndrome:

Specific etiology identified in what % pts?
40%

Often develops in child hospitalized for painful vasooculsion crisis
What complication:

-Sickle + chest pain + decreased breath sounds
-Sickle + CP + normal bs
Decreased bs: ACS

Normal bs: Rib infarct
What complication:

Sickle + cardiomegaly + lower lobe infiltrates + tachypnea; no chest pain
CHF (2/2 chronic anemia)
Aplastic crisis in sickle: may be due what infxn?
Parvo B19
Sickle: is EVERY fever an emergency?
YES - may be only sign of serious infxn
Sickle: susc to what 3 pathogens?
Strep pneumo
H flu
N mening
Sickle: what gallbladder complication?
Cholelithiasis

(often perform lap chole BEFORE develop gallstones)
Sickle: see precocious puberty?
NO - see delayed sex maturation
Sickle: why do pts snore?
Fxnl asplenia --> hypertrophy WALDEYERS RING
Sickle: what eye dz?
Proliferative retinopathy
Sickle: ppx lap chole?
YES - remove GB before develop G-stones --> infxn
Sickle: cure?
BMT
Sickle: tx w/what drug?
Hydroxyurea
Hydroxyurea: tx what dz?
Sickle (decrease freq & severity)
Sickle: give what vaccines if:

-<2yo
->2yo
Hib ALL pts

<2yo: PCV-23
>2yo: PCV-13 (polysacch)
Sickle:

-if sepsis --> what abx?
-what age initiate ppx?
Penicillin

Start ppx at 5-6yo
0-4mos: infant gains how much wt per day?
20-30 g/d
Malnutrition: decreased HC is early or late finding?
LATE

(brain usu spared)
FTT: definition:

-wt <____%
-wt for height <___%
Wt <3%

Wt for ht <3%
FTT: what % cases are NON-organic?
90%
How present: (what finding)

True milk-protein allergy w/FTT
BLOODY STOOLS
Lead level:

-toxic
-acute encephalopathy (#)
Toxic >10

Encephalo >100-150
Lead: suspect in what 2 types houses
<1950
Renovatd 1978
Lead screen: screen CAP or VENOUS?
CAPILLARY lead level --> confirm w/venous
Lead: universal screen in what 2 scenarios (community scenarios)? Screen what ages?
1. Prevalence >11%
2. >25% houses older than 1950

Screen 9-12mo --> repeat 2yo
What dz:

Microcytic anemia w/stippling
Lead poison
Lead poison: micro/normo/macrocytic anemia?
Micro
Lead poison: how affect:

-BP
-pulse
-rr
Increase ICP --> CUSHING

HTN
bradycardia
resp distress
Lead: see hypo or hyperphosphatemia?
HYPO
What dz:

Hypophosphatemia + urine coproporphyrin + glycosuria
Lead poison
Lead poison: see what molecule in urine?
Coproporphyrin
What dz:

CXR: hyperdense flecks
Lead poison
Tx what dz:

Dimercaprol
Lead poison
Tx what dz:

Calcium EDTA
Lead poison
Tx what dz:

Succimer
Lead poison
Tx what dz:

Penicillinamine
Lead poison
Lead poison: admit to hosp if lead what level?
>100 + sxs
Lead poison: how tx (what drugs):

-inpt (2)
-outpt (2)
Inpt:
1. Dimercaprol
2. INTRAVENOUS Ca2+ EDTA

Outpt:
1. Succimer
2. Penicillinamine
What drug:

Stims vomit center in brain --> vomit w/in 20 minutes
Ipecac
Ipecac:

-mxn
-how long until vomit?
-useful if poison w/in what time frame?
Stims vomit center in brain --> vomit in 20 mins

Useful if poison <30min
Ipecac: need to consult poison center first?
YES
Ipecac: contra-indicated in what age?
<6mo
Ipecac: contraindicated if infant ingests:

-LOW or HIGH viscosity hydrocarbon?
LOW
Ipecac: safe to use in pt w/coagulation disorder?
No - contraindicated
Poisoning:

Perform gastric lavage?
No clinical benefit
Activated charcoal:

Useful w/in how long from poison ingestion?
<1hr
Toxin ingestion: see fever?
Usu not
Reye's syndrome: affect ICP?
Increase ICP --> papilledema, change mental status --> diffuse encephalopathy
Metabolic dzs: p/w fever? Focal neuro findings?
No fever or focal neuro

P/w diffuse encephalo
ICH: focal or diffuse neuro?
FOCAL
Meningitis: see papilledema? focal neuro s/sx?
NO
Seizure disorder: see what lyte abns? (2)
Low Ca
Low Mg
Infant with mental status change: if high suspicion of etiology --> is head CT mandatory?
YES - GET HEAD CT
Cystic fibrosis:

How inherit? How many mutations?
AR
1,500 mutation
Cystic fibrosis:

Deficiency in what enzyme responsible for malabsorption?
Defic lipase
Cystic fibrosis:

Admin what % daily recommended cals?
120-150%
Recommended daily calories (kcal/kg/d):

-9w normal
-9w cystic fibrosis
normal: 100 kcal/kg/d

CF: 130-160
Cystic fibrosis:

What % calories should be fat?
40%

(contrast normal: 30%)
Cystic fibrosis:

Do minority or majority of teens develop CHRONIC PNA?
MAJORITY
Cystic fibrosis:

Replace what 3 enzymes? 4 vitamins?
Lipase
Amylase
Protease (Creon)
vitamin ADEK
Cystic fibrosis:

Sweat test --> how long until results?
DAYS
Cystic fibrosis:

MAIN dx test
Sweat test
(genotype is adjunctive)
(>60 is diagnostic)
Sweat chloride test:

-normal
-CF
Normal <60

>60 diagnostic
Cystic fibrosis:

Is genetic test diagnostic?
NO - req further testing (preferably sweat test)
Cystic fibrosis:

Vitamin E deficiency --> what complication?
HEMOLYSIS
Cystic fibrosis:

Hemolysis due to what deficiency?
Vitamin E deficiency
Cystic fibrosis:

In/decreased haptoglobin?
DECREASE (due hemolysis 2/2 vit E def)
Cystic fibrosis:

-in/decrease plts?
-retics?
Hemolysis (2/2 vit E def)-->

-increase plts
-increase retics
#1 bowel obstruction in 6mo-6yo
Intusseption
Intussception: what ages?

80% <___yo?
6mo - 6yo

80% <2yo
Intussception: M or F?
M>F
Intussception: which invaginates into other - prox vs. distal
Prox ALWAYS invaginates into distal
Intussception: intermittent or constant pain?
PAROXYSMS of pain
What dz:

paroxysmal abd pain + inconsolable + sausage in R abd
Intussception
Intussception: vomit? diarrhea?
Vomit: YES

Stool is CURRANT (blood & mucus)
Intussception: most common location
Ileocecal jxn
Intussception: underlying mxn (what stimulates telescope)?
Hypertrophied lymph tissue
Intussception: what dx imaging (2)?
Air or contrast enema
Name for:

Mid ear fluid + s/sx ear infxn (bulg, drainage)
ACUTE OM

(contrast OME - no s/sx)
How different:

AOM vs. chronic OME
AOM: fluid + s/sx

Chronic OME: fluid - s/sx
AOM: 4 most common bact pathogens
Strep pneumo
H flu
M cattarhalis
STREP PYOGENES
AOM: 3 common VIRAL pathogens
Influ
RSV
Rhino
AOM: higher bottle or breast? Assoc w/pacifier? genetic component?
Bottle
Increase risk if pacifier
FHx
AOM: M or F?
M > F
AOM: assoc w/SES?
Increased in LOW SES
AOM: highest what ethnicity?
Native American
What dz:

TMs retracted & amber & decreased mobility
Chronic OME
Ear exam to r/o AOM: which is more reliable:

TM color OR position/mobility
Position/mobility
Ear exam:

Is RED TM alone a good predictor of AOM?
NO
What test:

Objective eval TM mobility
Tympanogram
What test:

Audio thresholds via EARPHONES
Conventional audiometry
What test:

Audio threshold via SPEAKERS
Visual Reinforcement audiometry (VRA)
How different:

Conventional audiometry vs. Visual Reinforcement Audiometry
Conventional: earphones; >4yo

Visual: speakers; 6mo - 2.5yo
Conventional audiometry: can perform in what ages?
>4yo
Visual Reinforcement Audiometry: perform in what ages?
Speakers

6mo - 2.5yo
What test:

PHYSIOLOGIC test of COCHLEAR response to stimulation
Otoacoustic Emissions (OAE)
What test:

Use in newborn to assess hearing
Otoacoustic Emissions (OAE)

-physio test of cochlear response
AOM: what % resolve spontan?
50-80%
AOM: how tx DEFINITE dx in:

-0-2yo
->2yo
0-2: abx
>2: abx if SEVERE (39', pain)
UNCERTAIN AOM: must give abx if <___ (age)
<6mo

If 6mo -2yo --> you can observe (abx if 39', severe pain)
Chronic OME: assoc w/hearing loss?
YES --> lang delay
Chronic OME: how tx? (2 options)
watch & wait

if hearing loss --> TUBES
Name for:

Edges of optic disc blurred; narrow BVs
Papilledema
TTH or Migraine:

LATE in day
TTH
TTH: occur AM or PM?
PM
TTH or Migraine:

Triggered by stress
BOTH
TTH or Migraine:

Occipital
TTH
TTH or Migraine:

Tender neck muscles
TTH
TTH or Migraine:

BILATERAL
TTH
TTH or Migraine:

Any time of day
Migraine
Migraine: AM or PM?
Any time of day
TTH or Migraine:

Unilateral
Migraine
TTH or Migraine:

Can be triggered by foods
Migraine
TTH or Migraine:

Relieved with sleep
Migraine
What type of HA:

Bilateral vision changes + parasthesias + mental status changes
BASILAR migraine
Basilar migraine: how present?
Bilateral vision loss
Parasthesias
Mental status change
Suspect what type of pathology:

HA + developmental delay
Intracranial process
Febrile szs:

Occur EARLY or LATER in course of fever?
EARLY (1st day)
Febrile szs:

See with temp >___ C
>38C
Febrile szs:

Consider LP if <___ (age)
1st sz <12yo

(OR atypical sz w/slow return to baseline)
SIMPLE or COMPLEX febrile sz:

More common
Simple
SIMPLE or COMPLEX febrile sz:

GENERALIZED
SIMPLE!!!

(complex is focal)
SIMPLE or COMPLEX febrile sz:

<15mins
Simple
What is difference:

Simple vs. Complex febrile sz
Simple: <15min x 1; generalized

Complex: >15min x multi; focal
Febrile sz: what is % recurrence if 1st sz:

-<12mo
->12mo
<12mo: 50% recurrence

>12mo: 30% recurrence
Febrile sz:

increase risk epilepsy?
SLIGHT increase (esp if early & recurrent)
Febrile sz:

FHx?
Yes
True seizure: see PINTPOINT or DILATED pupils?
Pinpoint
What % infants w/meningitis p/w szs?
30%
Can a BENIGN VIRAL SYNDROME be responsible for fever without source?
YES

(may be indisting from occult bacteremia)
#1 pathogen in OCCULT BACTEREMIA
Strep pneumo
Infant with fever of unknown source: catheterize if:

-M <__(age)
-F <__(age)
M<6mo (after 6mos start to think less about occult UTI)

F<12mo
What % infants w/bacterial meningitis have fever?
95%
Infant w/bact meningitis: top 2 pathogens in IMMUNIZED:

-<2mo
-2mo - 12yo
<2mo: E coli & GBS

2mo-12yo: Strep pneumo + N mening
Bact meningitis: suspect GBS if under what age?
<2mo
Bact meningitis: initiate what abx?
IV cephalo + vanco
Bacterial meningitis: may lead to what HORMONAL complication?
SIADH
Bact meningitis: is it RARE or COMMON for txed mening to be fatal?
RARE
#1 VIRAL meningitis
Enterovirus
Viral meningitis: what cells predom CSF:

-0-48h
->48h
0-48h: PMNs

>48h: lymphocytes
Viral meningitis: see predom LYMPHOS in CSF after how many hours?
>48h
Viral meningitis: what VIRUS --> RBCs in CSF?
HSV
HSV meningitis: what CSF feature?
See RBCs
Shock: initial bolus (size & fluid)
20 cc ISOTONIC NS
Shock:

When initiate INTRAOSSEOUS access?
Fail periph: 90 seconds or 3 attempts
IV access in SHOCK:

What TYPE of central line is an approp alternative to periph line in older child
FEMORAL

(NOT subclavian or arterial)
Meningococcemia: 1st choice abx
IV PENICILLIN
Meningococcus: how prophylx:

-adult contacts
-children
Adult: cipro

Children: rifampin
Meningococcemia: admin what abx at discharge to elim carrier state?
CEFTRIAX
MCV4: safe what ages?
11-18yo
Meningococcemia:

-what % adols die? total die?
-what % have comps?
Fatal 25% adols, 10% total

10-20% comps
Hypernatremia: slow or rapid replace fluid?
SLOW!

Decrease Na 1 mEq / 2h

(10 mEq/d)
Leads to what lyte abn:

Drink boiled milk
Hypernatremia
Leads to what lyte abn:

Drink free H2O
Hyponatremia
How calculate:

Degree of dehydration (#)
Previous wt - current wt

(assumes all wt loss is free H2O)
Expect hypo/iso/hypernatremic loss:

Gastroenteritis
ISOnatremia

(not req to meas lytes)
Gastroenteritis: required to measure lytes?
No - only if mod/severe dehydr

(assume isonatremic loss)
Dehyrdation: give what SIZE BOLUS over what AMT TIME? repeat boluses how often?
20 cc NS over 20-60min

Repeat until normal UOP & HR
How calculate:

Fluid deficit (cc) =
wt (g) x % dehydration
Dehydration: if replace fluids ORALLY --> how many CCs per how much TIME?
5-10cc q 1-5min
Give how much maintenance fluid?:

8kg
8x100 = 800cc/d
Give how much maintenance fluid?:

14 kg
10x100=1,000
4x50=200

1,200
Give how much maintenance fluid?:

25 kg
10x100=1,000
10x50=500
5x20=100

1,600
Fluid balance:

Need to replace HOW MUCH fluid for stool loss? What type of fluid?
>5g per 4h

Use 1/2NS + 20KCl (no dextrose)
Normal saline: how much Na+? Cl?
154 each
Oral replacement therapy: able to use in MODERATE dehydration w/out vomit?
YES
Dehydration: when reintroduce breastmilk/full formula?
If no vomit & tolerates 1-2 ozs of ORT per feed
Give how much maintenance fluid?:

8kg
8x100 = 800cc/d
Give how much maintenance fluid?:

14 kg
10x100=1,000
4x50=200

1,200
Give how much maintenance fluid?:

25 kg
10x100=1,000
10x50=500
5x20=100

1,600
Fluid balance:

Need to replace HOW MUCH fluid for stool loss? What type of fluid?
>5g per 4h

Use 1/2NS + 20KCl (no dextrose)
Normal saline: how much Na+? Cl?
154 each
Oral replacement therapy: able to use in MODERATE dehydration w/out vomit?
YES
Dehydration: when reintroduce breastmilk/full formula?
If no vomit & tolerates 1-2 ozs of ORT per feed
Where is pathology:

BILLIOUS vomit
POST-AMPULLA
Where is pathology:

Bloody vomit
Above ligament of Treitz
#1 etio gastroenteritis
Rotavirus
Pyloric stenosis:

When present?
3w (1w - 5mo)
Pyloric stenosis:

Bilious?
No - immed vomit
Pyloric stenosis:

Where palpate olive?
Above & right umbilius
Pyloric stenosis:

See skin changes?
Often see jaundice
Pyloric stenosis:

What lyte abn?
Hypochloremic metabolic alkalosis
Pyloric stenosis:

What imaging? (2)
Abd U/S --> (if not avail) --> upper GI WITH CONTRAST
What dz:

Upper GI: STRING SIGN
Pyloric stenosis
Pyloric stenosis:

Does LACK of palpable olive --> affect suspicion?
YES --- speaks strongly AGAINST P.S.
Pyloric stenosis:

See diarrhea?
No
UTI:

see vomit? diarrhea?
Vomit yes,

no diarrhea -- may see loose stools
Gastroesoph reflux: see poor wt gain?
Baby can develop food aversion --> FTT
Baby w/normal growth --> acute vomit:

Suspect metabolic disorder?
Not if previously normal growth
HSP:

-peaks what age?
-M or F?
4-6yo (range 2-17)

2x M > F
HSP: underlying mxn?
viral/bact URI (50% pts )---> IgA-mediated
HSP: how affects platelts?
NORMAL PLATELETS!!!!
What dz:

URI --> IgA deposition --> leukocytic vasculitis
HSP
What dz:

erythematous macules/wheals --> petechiae --> purpura
HSP
HSP: where see purpura? (distrib)
Gravity-dependent & pressure-sensitive areas

ELBOWS, LOWER EXTREMS
HSP: what % pts have skin s/sx?
100%
HSP: order what 2 labs?
UA: ALWAYS; assess renal involve
(if see blood/protein --> order BUN, CR)

CBC: see NORMAL PLATELETS
HSP: see splenomeg?
No
HSP: req PT? PTT? Blood cx?
NO
HSP:

-resolves how long? what % recur?
-how tx?
-risk what GI comp?
4-6w; 30% recur

NSAIDs; STEROIDS FOR ABD PAIN

risk GI bleed & ileoilial intuss
ITP: more or less common than HSP?
LESS COMMON

(5:100k compared to 10:100k)
ITP:

-age?
-M or F?
2-5yo (younger than HSP)

M=F
What dz:

non-specific viral infxn --> anti-plt Abs that bind plt surface --> liver & spleen destroy plts
ITP
HSP or ITP:

YOUNGER
ITP (2-5yo)

(contrast HSP 4-6)
HSP or ITP:

M > F
HSP
HSP or ITP:

M = F
ITP
HSP or ITP:

IgA deposits
HSP

(contrast ITP: anti-plt Abs)
HSP or ITP:

Anti-platelet Abs
ITP

(contrast HSP: IgA deposits)
HSP or ITP:

Usually preceded by viral infxn
BOTH

HSP: viral/bact URI

ITP: non-specific viral infxn
ITP: presents with petech/bruising and what OTHER sxs?
NONE

(may see epistax, ICH)
ITP:

-hepatosplenomeg?
-arthralgia?
NO
ITP is intracranial hemorrhage common?
NO - 0.5%
ITP: plts <___?
<20k
ITP: do most pts develop significant bleed?
NO
What dz:

viral infxn --> PETECHIA, BRUISING --> normal WBC, platelets <20k
ITP
ITP: how tx? (3)
Steroid
IVIg
Rhogham (anti-D)
Leukemia: see change in platelets?
Decrease (<100k)

(BM infiltrate --> see other cytopenias)
What dz:

Petech/purp + bone pain + hepatosplenomeg
Leukemia
To percuss liver:

Child in what position?
Supine w/knees bent
Normal liver size:

-neonate
-child
Neonate: 3.5cm

Child: 2.0cm
Leukemia: see hepatomeg?
YES - due infiltration
Glycogen storage dz: see small or large liver?
Hepatomeg
Spleen palpable in what %:

-neonates
-children
-adols
Neonate: 33%

Child: 10%

Adol: 2%
Spleen: what size is ABNORMAL?
>2cm
See splenomegaly?:

Endocarditis
Yes
See splenomegaly?:

SLE
Yes
Which storage disease:

See splenomegaly
GAUCHER
LNs: abn if what size?
>2cm
Palpable LNs are considered NORMAL in what 3 areas?
Cervical
Ax
Inguinal

--> anywhere else is abn
DKA: see OSMOTIC DIURESES once BG is above what #?
180
T1DM: comprises what % total DM?
5-10%
T2DM: insulin level is low, normal or high?
Normal-high

(tissues are insulin-resistant --> need higher levels of insulin)
DM: screen if overweight (WHAT BMI %) and HOW MANY SXS?
BMI >85% and 2 s/sx

(FHx 1-2', race, HTN, dyslipid,etc)
DM: screen beginning what age? how often?
puberty --> q3 yrs
Pediatric insulin: how many injections per day? how distribute doses?
3-4 injxns/day

2/3 total in AM (1/3 rapid + 2/3 intermed) --> 1/6 dinner (rapid) --> 1/6 bed (intermed)
DKA: follow what LAB to monitor response to insulin?
SERUM ketones
What dz:

Increased beta-hydroxybutyrate
DKA
DKA: monitor URINE KETONES how often?
Every void until no ketones
DKA: how decide when to switch from IV to SQ insulin?
Switch once NO KETONES In serum or urine
DKA: how affect BUN, CR?
Usually normal

Increase if severely dehydrated
DKA: how affect:

-serum Na+?
-K?
HYPONATREMIA: due renal loss & osmotic movement of H2O into extracell

K+ low/normal/high (despite total body hypoK) --> provide K in IVF
DKA: admin K+ in IVF?
YES - give K+
DKA: cont insulin drip until:

-pH > #
-bicarb > #
pH > 7.3

Bicarb > 15
DKA: add DEXTROSE to IVF if BG <___
<300
DKA: what is tx goal:

-RATE of BG drop
-Target BG
Decrease 80-100 mg/dl per HOUR

Goal: 120-250
DKA: #1 reason of death
Cerebral edema 2/2 overrapid glucose correction
What dz:

Child w/DKA --> give insulin drip --> HA & mental status change --> death
Cerebral edema 2/2 overrapid correction
Cerebral edema 2/2 overrapid correct DKA:

-admin what drug to prevent?
MANNITOL IV 0.25-1mg/kgDue
Do children have lower or higher % total body H2O?
HIGHER

(increases risk of dehydration)
Dehydration: low or high sensitivity?:

Decreased UOP
HIGH
Dehydration: low or high sensitivity?:

Dry mucus membranes
HIGH
Dehydration: low or high sensitivity?:

Absent tearing
HIGH
Hypo/iso/hypernatremic dehydration:

Gastroenteritis
ISO
Dehydration: correct over how many hours?:

-hyponatremic
-iso
-hyper
Hypo: 24h
Iso: 12h
Hyper: 24h
How define (what seurm Na+):

-hyponatremic
-hyper
Hypo: <130

Hyper: >150
If severe hyponatremia (<120): think what 3 etios?
1. Free H2O
2. Dilute formula
3. Adrenal insuff
Hypo/iso/hypernatremic dehydration:

D.I.
Hyper (>150)
Insensible losses account for what % daily H2O req?
40%

(other 60% is UOP)
DKA: do you replace ongoing urine loss?
NO - mobilizing extracellular fluid

(you do replace stool losses)
How distinguish:

Trans synovitis of hip VS septic hip
DEGREE of inflamm (based WBC, ESR, CRP)
Transient synovitis of hip:

Common?
YES
Transient synovitis of hip:

LT sequela?
None
Transient synovitis of hip:

Low or high fever?
Low
Transient synovitis of hip:

Affect ROM?
DECREASED ROM
Transient synovitis of hip:

How long until resolve?
3-4d
Transient synovitis of hip:

How tx?
rest + ibuprofen --> f/u 2d to recheck CBC (r/o leukemia)
Can septic arthritis lead to avasc necrosis?
Yes - accum pus --> pressure --> decrease BF fem head
Septic arthritis: which pathogen common in neonate?
GBS
Septic arthritis: which pathogen in adol?
N gonorr
Septic arthritis: which species of strep?
Strep pyogenes
Strep pneumo
Septic arthritis: see joint warmth? redness?
Not always (since deep infxn)
Septic arthritis: joint asp has DECREASED or INCREASED viscosity?
DECREASED viscosity indicates infxn
Septic arthritis: how tx?
I & D! --> IV abx --> repeat asp
JRA: difference between:

Pauci & polyarticular
Pauci: <4 (usu large)

Poly >4 (usu small)
JRA: are all subtypes assoc w/fever?
No, only some
JRA: common to see rash?
YEs
JRA: dx requires s/sx to be present for how long?
6+ weeks
What dz:

Infxn --> Abs against joint
REACTIVE (post-infectious) arthritis

(NOT transient syno: inflamm of lining - no actual Abs)
Reactive arthritis:

Presents how long after initial infxn?
Few weeks
Reactive arthritis: due to what PATHOGENS:

-GI infxn (2)
-GU infxn
-Pharyngitis
GI: Yersinia, Shigella
GU: Chlam
Strep
What dz:

Joint pain + asp w/inflammatory cells + NEGATIVE asp cx
Reactive arthritis

(contrast septic: pos asp cx)
Reactive arthritis:

How tx?
ABX IF INFXN STILL PRESENT

otherwise NSAIDs for few wekes
Reactive arthritis:

More common lower or upper extrems? small or large joints?
Lower
Small
Sprain: what anatomic injury?
Tear ligament
See SPRAIN after fall?
NO

Req tearing motion
Occult fx: see how long s/p injury?
3-4w
Osteomyelitis: #1 pathogen
Staph aureus
Osteomyelitis: ACUTE or INDOLENT pain?
INDOLENT!!!

Delays abx 5-10d
Osteomyelitis: what % pts present with fever but no pain?
50%
Suspect what dz:

Limp + jaw pain
Leukemia w/BM infil
VSD: why not present in neonate?
High pulm vasc R in neonate --> no reason for blood to shunt to pulm vasc rather than systemic
VSD: how result in poor feeding?
LV overload --> CHF --> increased RR --> difficult feeding
What dz:

Sweat during feed; tire during feed
CHF (e.g. 2/2 VSD)
CHF: #1 phys finding
TACHYPNEA
What dz:

Tachycardia w/gallop rhythm
CHF
VSD: is murmur intensity correl with size of defect?
NO
What MURMUR:

Loud, blowing holosystolic at LLSB
VSD
VSD: when present?
Few days s/p birth
VSD: where best ausc?
Lower left sternal border
VSD: does magnitude of shunt affect the age of presentation?
YES

larger defect --> earlier CHF
VSD: defect becomes smaller or larger with time?
SMALLER

(75% small & 50% total will close)
VSD: what % total close?
50%

(75% small VSDs)
VSD: expect abn EKG?
YES - see RV dominance
4 defects that cause murmur AND CHF
1. VSD
2. Ao stenosis
3. Ao coarct
4. large PDA
Lead to CHF?:

PDA
Yes (if large)
Lead to CHF?:

ASD
No
Lead to CHF?:

TOF
No
Infant CHF: req inpatient tx?
YES
How tx:

-CHF due VSD
-CHF due cardiomyopathy
VSD: digoxin + furesomide

Cardiomyo: ACE-I
VSD: decide surgery at what age?
6mo
Shaken Baby Syndrome:

-what % die? what % poor neuro outcome?
-account what % child abuse death?
25% die, 40% poor neuro outcome

10% child abuse death
Shaken Baby Syndrome:

Pinpoint OR dilated pupils?
DILATED
Shaken Baby Syndrome:

Stiff or limp?
STIFF
Shaken Baby Syndrome:

Higher mortality if <1yo or >1yo?
<1yo
Shaken Baby Syndrome:

What TYPE of brain bleed?
Subdural
Subdural bleed in neonate: 2 main etios?
1. Shaken baby
2. Vacuum

NOT szs
Increased ICP in neonate: how affect breathing?
See APNEA
Bacterial mening in neonate: what % have hearing loss?
20%
Arrythmia: common to see apnea?
NO

See: decreased feed, irritable, lethargic
Suspect increased ICP if:

SLOW or RAPID rr?
SLOW
R/o subdural bleed: what imaging 1st?
CT --> serial CT to monitor
Which brain imaging best for:

Shearing injury
MRI
Shaken Baby Syndrome:

-Administer what ppx meds?
-what imaging (aside from brain)?
Anti-epileptics

Skeletal survey
Apnea: definition (2)
1. No breathe >20s

2. No breath (<20s) plus brady (<100) or pallor-cyanosis
#1 problem in prematures
Apnea
Gallop: common in peds?
No
What murmur:

Continuous diastolic murmur
PDA

(PATHOLOGIC)
Common or rare?:

Endocarditis
Rare
Common or rare?:

Cardiomyopathy
Rare
Innocent murmurs: common what age? due to defect?
3-7yo

NOT defect (due vibration)
#1 innocent murmur
Still's
What murmur:

musical, vibratory murmur in LSB while supine
Still's (innocent)
Still's murmur: best heard standing or supine?
SUPINE
What murmur?:

Widely split, fixed S2
ASD
ASD: presents what ages?
3-5yo

(contrast VSD: few days s/p birth)
What murmur:

Presents 3-5yo
ASD
What murmur?:

Initially syst ejection murmur --> early diast murmur
Ao stenosis

(leads to Ao insuff)
What murmur?:

S1 --> systolic ejection click --> harsh systolic murmur
Pulmonic stenosis
PDA: louder in dias or syst?
SYST loudest
(although continuous)
What murmur?:

Holosystolic, blowing
VSD
What murmur?:

PROGRESSIVE; detect any age; p/w HTN in upper extrems
Ao coarct
Detect what age:

Bicuspid Ao valve
Adol/adult
1st & most subtle sign of inadequate circulation
tachycardia
Femoral pulse: represents periph or central pulse?
Central

(sim carotid)
What type of shock:

WARM EXTREMS
Septic
Can viral infection lead to septic shock?
Yes (via toxin production)
What type of shock:

ADEQUATE UOP
Septic
What type of shock:

Bounding pulse
Septic
Septic shock:

How tx? (2 immed management steps)
Boluses --> Vasopressors (E/NE/DA)
Leads to what type of shock?:

Cardiomyopathy
Cardiogenic
Leads to what type of shock?:

Tamponade
Cardiogenic
Cardiogenic shock:

Cool or warm extrems?
Cool
Cardiogenic shock: how affect UOP?
Decrease UOP
Leads to what type of shock?:

Anaphylaxis
Distributive shock
Leads to what type of shock?:

SIRS
Distributive shock
Hypoglycemia: see fever?
No
Encephalitis: how affect resp rate?
NORMAL --- tachypnea uncommon!

(contrast meningitis)
PNA in infant: expect mental status change?
No
Toxic shock syndrome: how does rash appear?
Sunburn-like sandpaper
What dz:

Pastia's Sign
Scarlet Fever

(linear petechia in body folds)
Scarlet Fever: see desquam?
Yes (5d after rash)
Name for:

Scarlet Fever --> linear petechia in body folds
Pastia's sign