Pediatrics Brs Chapter 16

Front 1

Leading Cause of death in childhood?

Back 1

Cancer (usually of unknown etiology)

Front 2

Wiskott-Aldrich Syndrome is characterized by (3a)? Associated with (2b)?

Back 2

1a. ImmunoDef: B and T cell dysfx
2a. atopic dermatitis
3a. thrombocytopenia
b. leukemia and lymphoma

Front 3

Immunodeficency disease Characterized by B and T cell dysfx, atopic dermatitis
and thrombocytopenia. Often associated with leukemia and lymphoma.

Back 3

Wiskott-Aldrich Syndrome

Front 4

Immuno-Def disease associated with EBV infection

Back 4

X-linked lymphoproliferative dz

Front 5

T/F - Abdominal mass considered malignant until proven otherwise in children.

Back 5

True

Front 6

Most common childhood cancer

Back 6

ALL

Front 7

ALL
1. peak incidence/Gender/Race
2. Cause?
3. Classification? most common in children?
4. Staging?

Back 7

1. 2-6yoa, M, W
2. unknown cause
3. L1-3, L1 most common
4. no staging, most disseminated

Front 8

T/F - a normal CBC rules out leukemia

Back 8

False - CBC Suggests ALL via anemia, thrombocytopenia, and variable WBC. Confirmed by BM Bx

Front 9

Treatment of ALL (3)

Back 9

1. Induction - Steroids, Vinc, L-asp and Intrathe MTX
2. Consolidation - prevent CNS invol, Intrath. MTX and Cranial Rad for high risk
3. Maintenance - upto 3 years

Front 10

Type of Workup and Rx for neutropenic with Fever

Back 10

Sepsis until proven otherwise and IV empiric Abx post drawing cultures

Front 11

Metabolic Complications of Tumor Lysis Syndrome

Back 11

HyperPUK - phosp, uricemia, kalemia

Front 12

AML
1. Cause
2. CNS involvement?
3. Symptoms

Back 12

1. unknown
2. more common than ALL
3. fever, HSM, gingival hypertrophy

Front 13

T/F - juvenile chronic myelogenous leukemia is not associated with BCR-ABL.

Back 13

true

Front 14

Most common physical exam Lymhoma in children

Back 14

painless lymphadenopathy

Front 15

B symptoms

Back 15

fever, night sweats, or > 10 weight loss

Front 16

Complications of Rx of Hodgkin's Dz (4)

Back 16

1. Growth retard
2. 2/2 malignancy
3. hypothyroid
4. male sterility

Front 17

Lymphoma must be considered as "lead point" for what in any child older than 3?

Back 17

intussception

Front 18

Second most common childhood cancer (most common solid)

Back 18

Brain tumors

Front 19

Brain Tumors in Children by most common (4)

Back 19

1. Glial cell (astrocytomas)
2. PNET (medullobl)
3. ependyomas
4. craniopharyngiomas

Front 20

T/F - Infratentorial tumors are more common than supratentorial btw 1 and 12.

Back 20

True

Front 21

Preferred neuroimaging modality.

Back 21

MRI

Front 22

T/F - Try if possible to reserve radiation for children older than 3.

Back 22

False, older than 5 yoa

Front 23

Poorest prognosis with brain tumors.

Back 23

Brainstem glioma

Front 24

Neuroblastoma
1. incidence
2. anatomical occurence
3. lab findings, definitive?
4. management (2)

Back 24

1. 1st 5y of life
2. 3/4 in abdomen/pelvis
3. excess urine cathecholamines: VMA/HVA, definitive with BM bx + urine, or tissue bx
4. CT/bone scan (tumor spread). Surgery +/- Chemo/RT

Front 25

3 yo with firm abdominal mass that crosses midline showing symptoms of flushing, HTN, HA, sweating, and has excess urine catecholamines. Dz?

Back 25

Neuroblastoma

Front 26

Most common childhood renal tumor

Back 26

Wilms' tumor

Front 27

Wilms' Tumor (nephroblastoma)
1. peak incidence
2. anatomical occurence
3. Congenital Malformations (3)

Back 27

1. 3/4 younger than 5 yoa
2. abdominal mass that rarely crosses the midline
3. G/U mal, Hemihypertrophy, Sporadic aniridia

Front 28

3 year old with abdominal pain and mass that does not cross the midline and concomitant hematuria. Dz?

Back 28

Wilms' Tumor

Front 29

Most common soft tissue sarcoma in childhood

Back 29

Rhabdomyosarcoma

Front 30

Rhabdomyosarcoma
1. incidence
2. initial presentation and involvement
3.

Back 30

1. 2/3 < 10 yoa
2. painless soft tissue mass with most commonly Head and neck involvement in 40%

Front 31

Chemosis?

Back 31

conjunctival edema

Front 32

Most common malignant bone tumor

Back 32

osteogenic sarcoma

Front 33

Osteo Sarcoma
1. peak/gender
2. anatomical occurence

Back 33

1. peaks during rapid growth phase in adolescence, Males
2. 1/2 around knee, located in metaphysis of long bone

Front 34

Which OsteoSarcoma or Ewings is associated with Systemic symptoms? sunburst on XR? oninon skinning on XR? Small Round Blue Cells?

Back 34

Systemic Symptoms - Ewings
Sunburst - OS
Onion - Ewings
SRBCs - Ewings

Front 35

Most common type of liver tumor in childhood

Back 35

hepatoblastoma (usually younger than 3 yoa)

Front 36

Marker of Liver tumors

Back 36

alpha - fetoprotein

Front 37

Most common teratoma in first year of life

Back 37

Sacrococcygeal teratoma (most often in females and benign)

Front 38

Testicular tumors are assocaitated with? % benign?

Back 38

cryptoorchid testes. 1/3 are benign

Front 39

4 year old with solid firm painless testicular mass with elevated serum alpha-fetoprotein? dz?

Back 39

Yolk sac tumor