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39 Cards in this Set

  • Front
  • Back
Leading Cause of death in childhood?
Cancer (usually of unknown etiology)
Wiskott-Aldrich Syndrome is characterized by (3a)? Associated with (2b)?
1a. ImmunoDef: B and T cell dysfx
2a. atopic dermatitis
3a. thrombocytopenia
b. leukemia and lymphoma
Immunodeficency disease Characterized by B and T cell dysfx, atopic dermatitis
and thrombocytopenia. Often associated with leukemia and lymphoma.
Wiskott-Aldrich Syndrome
Immuno-Def disease associated with EBV infection
X-linked lymphoproliferative dz
T/F - Abdominal mass considered malignant until proven otherwise in children.
Most common childhood cancer
1. peak incidence/Gender/Race
2. Cause?
3. Classification? most common in children?
4. Staging?
1. 2-6yoa, M, W
2. unknown cause
3. L1-3, L1 most common
4. no staging, most disseminated
T/F - a normal CBC rules out leukemia
False - CBC Suggests ALL via anemia, thrombocytopenia, and variable WBC. Confirmed by BM Bx
Treatment of ALL (3)
1. Induction - Steroids, Vinc, L-asp and Intrathe MTX
2. Consolidation - prevent CNS invol, Intrath. MTX and Cranial Rad for high risk
3. Maintenance - upto 3 years
Type of Workup and Rx for neutropenic with Fever
Sepsis until proven otherwise and IV empiric Abx post drawing cultures
Metabolic Complications of Tumor Lysis Syndrome
HyperPUK - phosp, uricemia, kalemia
1. Cause
2. CNS involvement?
3. Symptoms
1. unknown
2. more common than ALL
3. fever, HSM, gingival hypertrophy
T/F - juvenile chronic myelogenous leukemia is not associated with BCR-ABL.
Most common physical exam Lymhoma in children
painless lymphadenopathy
B symptoms
fever, night sweats, or > 10 weight loss
Complications of Rx of Hodgkin's Dz (4)
1. Growth retard
2. 2/2 malignancy
3. hypothyroid
4. male sterility
Lymphoma must be considered as "lead point" for what in any child older than 3?
Second most common childhood cancer (most common solid)
Brain tumors
Brain Tumors in Children by most common (4)
1. Glial cell (astrocytomas)
2. PNET (medullobl)
3. ependyomas
4. craniopharyngiomas
T/F - Infratentorial tumors are more common than supratentorial btw 1 and 12.
Preferred neuroimaging modality.
T/F - Try if possible to reserve radiation for children older than 3.
False, older than 5 yoa
Poorest prognosis with brain tumors.
Brainstem glioma
1. incidence
2. anatomical occurence
3. lab findings, definitive?
4. management (2)
1. 1st 5y of life
2. 3/4 in abdomen/pelvis
3. excess urine cathecholamines: VMA/HVA, definitive with BM bx + urine, or tissue bx
4. CT/bone scan (tumor spread). Surgery +/- Chemo/RT
3 yo with firm abdominal mass that crosses midline showing symptoms of flushing, HTN, HA, sweating, and has excess urine catecholamines. Dz?
Most common childhood renal tumor
Wilms' tumor
Wilms' Tumor (nephroblastoma)
1. peak incidence
2. anatomical occurence
3. Congenital Malformations (3)
1. 3/4 younger than 5 yoa
2. abdominal mass that rarely crosses the midline
3. G/U mal, Hemihypertrophy, Sporadic aniridia
3 year old with abdominal pain and mass that does not cross the midline and concomitant hematuria. Dz?
Wilms' Tumor
Most common soft tissue sarcoma in childhood
1. incidence
2. initial presentation and involvement
1. 2/3 < 10 yoa
2. painless soft tissue mass with most commonly Head and neck involvement in 40%
conjunctival edema
Most common malignant bone tumor
osteogenic sarcoma
Osteo Sarcoma
1. peak/gender
2. anatomical occurence
1. peaks during rapid growth phase in adolescence, Males
2. 1/2 around knee, located in metaphysis of long bone
Which OsteoSarcoma or Ewings is associated with Systemic symptoms? sunburst on XR? oninon skinning on XR? Small Round Blue Cells?
Systemic Symptoms - Ewings
Sunburst - OS
Onion - Ewings
SRBCs - Ewings
Most common type of liver tumor in childhood
hepatoblastoma (usually younger than 3 yoa)
Marker of Liver tumors
alpha - fetoprotein
Most common teratoma in first year of life
Sacrococcygeal teratoma (most often in females and benign)
Testicular tumors are assocaitated with? % benign?
cryptoorchid testes. 1/3 are benign
4 year old with solid firm painless testicular mass with elevated serum alpha-fetoprotein? dz?
Yolk sac tumor