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35 Cards in this Set

  • Front
  • Back

Clinical signs and symptoms of anaphylaxis usually occur within _ time of exposure to offending agent.

30 minutes

Dz that is an IgE mediated inflammatory response in the nasal mucosa to inhaled antigen?

Allergic Rhinitis

2 most common causes of perennial rhinitis

dust mites, animal dander

Most effective method to diagnose allergic rhinitis? What must be stopped 4-7 days prior to testing?

skin test with purified antigen. Must stop antihistamines!

Most effective class of drugs for controlling rhinitis symptoms? Other agents (4)?

intranasal steroids most effective, than antihistamines, intranasal cromolyn Na, decongestants (beware rebound), immunotherapy

Chronic inflammatory skin condition characterized by dry skin, pruritus and lichenification

Atopic Dermatitis (eczema)

T/F - Eczema typically begins in early infancy

True

Describe the Acute and Chronic Changes of Eczema

Acute - erythema, weeping/crusting, often 2ndry infection;
Chronic - lichenification, pigment changes (hyper > hypo)

Diagnostic Criteria of Atopic Dermatitis

3/4 Major Criteria
1. pruritus, 2. FH, 3. typical morphology & distrib
4. relapsing/chronic drmatitis

T/F - Exclusive breastfeeding for 6 months may decrease food allergies and eczema in an infant

True

The Test for Food Allergies?

Radioallergosorbent Test (serum IgE for food antigens)

Definitive Test for Food hypersensitivity

Double blind placebo controlled food challenge

What is circumscribed, raised, evanexcent areas of edema that are almost always pruritic?

Urticaria (hives)

2 groups at specific risk for latex allergy

health care worksers and myelomingocele

Time frame btw Acute and Chronic Urticaria

> 6 months = chronic

Selective IgA deficiency is characterized by serum IgA? Treatment?

serum < 7 mg/dL, IgA cannot be replaced so management is ia treating infections and other complications

Most common immune deficiency

IgA deficiency

How can you determine diminished antibody funciton?

measure titers in response to childhood immunizations

What is Common Variable Immunodeficiency? Treatment?

heterogenous group of disorders of hypogammaglobulinemia;
Treatment - Monthly IVIG replacement, Aggressive ABX management, chronic diarrhea management

Increased susceptibility to infection with the first few months of life with common and opportunistic infection is common with?

SCID

Management of SCID (4)?

1. irradiated blood products
2. Monthly IVIG replaced
3. PCP Prophylaxis (TM-SMX)
4. BMT can be curative

Describe Ataxia Telanctasia (5)? Should Avoid What?

1. Auto Recessive Chr. 11
2. Combined ImmDef
3. Cerebellar Ataxia (wheelchair by adolesc)
4. Oculocut. Telangiectasisa
5. Predisposition to Malignancy so Avoid Ionizing Radiation

Describe the features of Digeorge Syndrome?

CATCH-22;
Cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, microdelection on 22q11

Describe the features of Wiskott-Aldrich Syndrome (4)?

X linked disorder of Combined ImDef, Eczema, and Thrombocytopenia

What organisms are Wiskott-Aldrich patients susceptible to specifically?

encapsulated organisms

Diagnostic Tests in W-A syndrome(2)? Therapy?

CBC (thrombocytop), IgM decreased; Therapy of choice is HLA-matched BMT with IVIG and splenectomy + prophylactic abx

X-Linked Bruton's Agammaglobulinemia is characterized by ? Treatment?

severe B cell deficiency with normal T cells; Treatment IVIG

Chronic Granulomatous Disease is predominately inherited by ?

X-linked

Diagnositic Test for CGD (2).

nitroblue tetrazolium or flow cytommetric assay

Treatment of CGD (5)

1. drain abscesses
2. prophy. TM-SMX
3. prophy. itraconazole
4. IFN-gamma
5. BMT is curative

AutoRec condition characterized by decreased neutrophil chemotaxis, cyclic neutropenia, and pancreatic exocrine insuf. Patient often presents recurrent soft tissue infections, chronic diarrhea, and FTT.

Schwachman-Diamond Syndrome

Syndrome of variable neutropenia and thrombocytopenia with gian lysosomal granules in PMNs. Also with partial oculocutaneous albinism.

Chediak-Higashi Syndrome

Defiecienices of early components of complement are associated with _.

A/I dz

Defiecienices of late components of complement are associated with _.

meningococcal and gonococcal infections

T/F - A total serum hemolytic CH50 complement indicates fully functional pathway.

True