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28 Cards in this Set
- Front
- Back
what is the storage duration for :
whole blood packed RBCs Platelets FFP/cryo frozen FFP/cryo thawed |
whole blood: 35 days
packed RBCs: 42 days (**in AS**) Platelets: 5 days FFP/cryo frozen: one year FFP/cryo thawed: 24 hours |
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what is the crit of RBC with AS added?
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goes from HCT of 70% to Hct of 53-61%
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expected Hct rise for 5ml/kg transfusion of AS RBC
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1.5g/dl
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Two viruses not inactivated in plasma by physical and chemical techniques. Why not?
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parvo b19 and HAV - they are not enveloped
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is DAT positive in allo or auto immune hemolysis
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both
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what is the difference between direct and indirect anti-globulin testing?
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direct: anti human IgG mixed with patient RBC
Indirect: patient serum (with patient IGG) combined with RBC of known specificity |
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development of which alloantibodies are most common in transfused sickle cell patients
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Anti C, anti- kell, anti-lewis
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why wash platelets or RBCs
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remove plasma proteins that cause allergic reaction
washing may remove high levels of extracellular K from RBC (particularly important in older bags of RBCs) |
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what percent RBCs are lost in washing?
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20%
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how long do you have to give washed platetlets or RBCs
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platelets: 4 hours
RBCs: 24 hours |
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what are the published indications for granulocyte transfusion?
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neonate less than 2 weeks old, bacterial sepsis, ANC < 300
bacterial sepsis, no response to antibiotics, ANC < 500 patients with functional neutrophil defect and documented infection, inresponsive to antibodies |
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why leukoreduce platelet tansfusion
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decrease HLA antibody alloimmunization
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how does irradiation prevent Transfusion associated GVHD
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makes T cells in product incapable of proliferating
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should blood from relatives be irradiated
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all blood direct donated from relatives should be irradiated
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when does TA GVHD occur? what are the symptoms?
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4-30 days after transfusion
rash, diarrhea, fever, aplastic anemia |
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what is the effect of irradation of potassium in RBC sample
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accelerated K leak, shortens RBC shelf life to 28 days
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does cryoprecipiate undergo viral inactivation?
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no
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what are the indications for cryo?
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hypofibinogenemia
factor 13 deficiency |
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most common causes (3) of transfusion related death?
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- error in ABO compatibility
- bacterial contamination - transfusion related acute lung injury |
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rate of transmission of parvovirus and t cruzei from transfusion
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1: 40,000-42,000
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who gets CMV "safe" blood
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LBW infants (<1200 gm)
solid organ transplant patients BMT patients other immunodeficienes |
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what causes acute hemolytic transfusion reactions (AHTR)
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complement mediated, intravascular RBC destruction due to presence of preexisting anti A or anti B antibodies
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when does delayed hemolytic transfusion reaction occur
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days to weeks after transfusion
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what causes TRALI?
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transfusion of antibodies to HLA or neutrophil antigens that result in increased capillary permeability
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when do irradiated RBC units need to be discarded?
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28 days
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current risk of HIV infection with RBC transfusion
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1:1.5million
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What is a risk associated with prothrombin complex concentrates
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myocardial infarction
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what is contained in prothrombin complex concentrates
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factors 2,7,9,10
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