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28 Cards in this Set

  • Front
  • Back
what is the storage duration for :

whole blood
packed RBCs
FFP/cryo frozen
FFP/cryo thawed
whole blood: 35 days
packed RBCs: 42 days (**in AS**)
Platelets: 5 days
FFP/cryo frozen: one year
FFP/cryo thawed: 24 hours
what is the crit of RBC with AS added?
goes from HCT of 70% to Hct of 53-61%
expected Hct rise for 5ml/kg transfusion of AS RBC
Two viruses not inactivated in plasma by physical and chemical techniques. Why not?
parvo b19 and HAV - they are not enveloped
is DAT positive in allo or auto immune hemolysis
what is the difference between direct and indirect anti-globulin testing?
direct: anti human IgG mixed with patient RBC

Indirect: patient serum (with patient IGG) combined with RBC of known specificity
development of which alloantibodies are most common in transfused sickle cell patients
Anti C, anti- kell, anti-lewis
why wash platelets or RBCs
remove plasma proteins that cause allergic reaction

washing may remove high levels of extracellular K from RBC (particularly important in older bags of RBCs)
what percent RBCs are lost in washing?
how long do you have to give washed platetlets or RBCs
platelets: 4 hours
RBCs: 24 hours
what are the published indications for granulocyte transfusion?
neonate less than 2 weeks old, bacterial sepsis, ANC < 300

bacterial sepsis, no response to antibiotics, ANC < 500

patients with functional neutrophil defect and documented infection, inresponsive to antibodies
why leukoreduce platelet tansfusion
decrease HLA antibody alloimmunization
how does irradiation prevent Transfusion associated GVHD
makes T cells in product incapable of proliferating
should blood from relatives be irradiated
all blood direct donated from relatives should be irradiated
when does TA GVHD occur? what are the symptoms?
4-30 days after transfusion

rash, diarrhea, fever, aplastic anemia
what is the effect of irradation of potassium in RBC sample
accelerated K leak, shortens RBC shelf life to 28 days
does cryoprecipiate undergo viral inactivation?
what are the indications for cryo?
factor 13 deficiency
most common causes (3) of transfusion related death?
- error in ABO compatibility
- bacterial contamination
- transfusion related acute lung injury
rate of transmission of parvovirus and t cruzei from transfusion
1: 40,000-42,000
who gets CMV "safe" blood
LBW infants (<1200 gm)
solid organ transplant patients
BMT patients
other immunodeficienes
what causes acute hemolytic transfusion reactions (AHTR)
complement mediated, intravascular RBC destruction due to presence of preexisting anti A or anti B antibodies
when does delayed hemolytic transfusion reaction occur
days to weeks after transfusion
what causes TRALI?
transfusion of antibodies to HLA or neutrophil antigens that result in increased capillary permeability
when do irradiated RBC units need to be discarded?
28 days
current risk of HIV infection with RBC transfusion
What is a risk associated with prothrombin complex concentrates
myocardial infarction
what is contained in prothrombin complex concentrates
factors 2,7,9,10