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13 Cards in this Set
- Front
- Back
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absorption
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variations in peripheral blood flow can occur and may result in unpredictable absorption of parenterally administered drugs
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GI function
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gastric pH and emptying time vary during development
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distribution
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differences in amt of body water, fat, plasma protein= different Vd
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metabolism
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phase I develops earlier than phase II in neonates
generally less effective than adults |
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excretion
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by 1 yo, adult renal function is attained
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youngs rule
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adult dose x (age in years/age+12)
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weight
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adult dose x (weight in lbs/150)
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surface area
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table
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best method to determine how much dug to give child
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published peds dosing
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how do drugs cause kernicterus in kids?
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compete with bilirubin for plasma proteins
BBB is not developed enough to keep bilirubin out |
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tetracycline
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stains teeth
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growth retardation
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amphetamine
methylphenidate |
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aspirin
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reyes
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