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15 Cards in this Set

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____ can protect AS of ACHesterase from IRReversible cholinesterase inhibitor
reversible cholinesterase inhibitor
Treatment/antidote of IRReversible cholinesterase inhibitors? (2)
1)atropine
2)cholinesterase reactivators
How does ATROPINE work as a treatment/antidote of IRReversible cholinesterase inhibitors?
blocks muscarinic receptors (central and peripheral) to prevent over stimulation via IRReversible cholinesterase inhibitors
What is the 1 cholinesterase reactivator?
2-PAM
How does 2-PAM work as a treatment/antidote of IRReversible cholinesterase inhibitors?
acts against IRReversible cholinesterase inhibitor in PERIPHERY ONLY
What makes 2-PAM ineffective?
"aging"
Cholinolytic drugs
a)1 of em
b)mechanism
a)Atropine
b)muscarinic receptor ANTAgoinst
Atropine
a)sites of axn
b)type of antagonist? meaning...
c)effects on nicotinic receptors?
a)all muscarinic receptors (central and periphery)
b)competitive reversible antagonist; can be overridden by increased [] of muscarinic agonist
c)can block nicotinic in high []s
Order of blockade of muscarinic receptors via atropine (4)
1)salivary, bronchial, sweat glands
2)iris, ciliary muscle, vagus to heart
3)bladder, GI smooth muscle
4)gastric acid secretion
Which muscarinic receptors does atropine effect
ALL, M1-M5
Therapeutic uses of Atropine (muscarinic antagonist) (9)
1)mydriatic
2)cycloplegic (blurred vision)
3)treat acute rhinitis, allergic coryza
4)preanesthetic medication to cause xerostomia (dry mouth)
5)treat CV disorders like vagal-induced heart block
6)treat bronchial asthma
7)treat ulcers of GI tract by blocking contractility or decr acid secretion
8)antidote to poisoning by cholinesterase inhibitors
9)treat Parkinson's
Atropine adverse effects (muscarinic antagonist) (8)
1)xerostomia
2)blurred vision
3)photophobia/mydriasis
4)tachycardia
5)anhidrosis (lack of sweating)
6)heat stroke
7)urinary retention
8)CNS excitation/depression depending on dose
Atropine contraindications (2)
1)narrow glaucoma
2)chronic lung disease
Mydriasis always contraindicates...
narrow angle glaucoma
Atropine contraindicates chronic lung disease via...(3)
1)emphysema
2)asthma
3)excess drying in airways