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19 Cards in this Set
- Front
- Back
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oxytocin
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-peptide hormone
-OXYR is a g protein receptor |
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properties that regulate movement of substances
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pressure, diffusion due to concentration gradients, electrical charge
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substances that can diffuse
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1,25 (OH)2 vit D, fatty acids, steroids, O2, CO2
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simple diffusion
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lipid soluble substances
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passive transport (protein channel)
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-ion channels (voltage gated, ligand gated, mechanically gated)
-Na, K, Cl, Ca -aquaporins |
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passive transport (uniporter/carrier)
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-conformational change of spanning protein
-no free flow of molecules -glucose transporters |
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primary active transport
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-uses ATP
-substances against concentration gradient -Na/K ATPase -Ca ATPase |
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secondary active transport
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-uses energy from concentration gradient
-co-transporters (Na down/glucose up) -exchangers (Cl/HCO3) |
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Glut4
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-when insulin binds, favors exocytosis of vesicles (and vice versa)
-fat and muscle cells |
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AQP2
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-kidney collecting duct epithelial cells
-when vasopressin binds, favors exocytosis (and vice versa |
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nicotinic acetylcholine receptor (nAChR)
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-skeletal muscle
-causes muscle contraction -messenger is acetylcholine -agonist is nicotine -antagonists are curare an bungarotoxin -ionotropic receptor |
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ionotropic receptor
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ligand gated ion channels where binding site and channel are part of same protein
ex. nAChR |
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metabotropic that functions as enzyme
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-ligand binding activates receptor protein to catalyze some reaction on intracellular surface
ex. insulin receptor |
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metabotropic GPCRs
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-ligand binding activates the G-protein, which then goes on to do various different activities
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right toe corticospinal interneuron
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-cell body in the left motor cortex of the brain
-axon crosses from left to right in brain stem -axon terminal synapses onto dendrites of motor neuron on the right side of the spinal cord |
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right toe motor neuron
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-cell body in spinal cord
-axon exits spinal cord -synapses onto toe muscle which causes movement |
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S4 helix
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confers voltage sensitivity to voltage gated channels
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TTX
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blocks voltage gated Na channels
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TEA
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blocks voltage gated K channels
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