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31 Cards in this Set
- Front
- Back
what is diphenylalkylamine
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verapamil
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what are the propertiets of verapamil
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has anti arr effects
arteriolar vasodilator coronary vasodilator negative inotropic effects |
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what drugs will decrease automaticity in SA node
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verapamil/dilitizem
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what drugs are arteriolar vasodilators
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nifidepine
verapamil diltiazem |
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what is the MOA of arteriolar vasodilation of verapamil/dilitiazem
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decrease Ca entry into vascular smooth muscle leading to decrease in PVR, BP, afterload, and O2 demand
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when would a coronary vasodilator be used
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if vasospasm is cause of angina
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what is the negative inotropic effect of Ca channel blockers
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decrease Ca entry into cardiac muscles leading to decreased in contractility and O2 demand
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what effect do verapamil and dilitizem have on venous return
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none
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what is the main effect of both verapamil and dilitiazem
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decrease O2 demand by:
decrease afterload decrease cardiac contractilty |
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in what case would dilitiazem decrease O2 demand and increase it supply as well
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it will increase O2 supply if angina is due to vasospasm
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what is an example of a dihydropyridine
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nifedipine
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what are the properties of nifedipine
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PDE inhibitor
increases cAMP MORE POTENT ARTERIOLAR VASODILATOR THAN VERAPAMIL AND DILITIAZEM |
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why is DHP not a good choice for angina
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may cause reflex tachycardia which would increase O2 demand
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what is the mechanism of action in angina of beta blockers
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decrease HR and contractility therefore less O2 demand
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what class of drug has shown to decrease mortality
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Beta blockers
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what is a negative effect of Beta blockers
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increase LVEDP due to negative inotropic effects
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what is a possible negative effect of negative inotropic effects
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increase LVEDP
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what are the properties of ranolzaine
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inhibits late Na current
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what is ranolazine indicated for
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chronic angina if not adequately controlled by standard therapy
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what is the benefit of adding NITRATE PULS BETA BLOCKER
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beta blocker blocks reflexogenic increase in HR and contractility which nitrates produce
Nitrates attenuate increase in LVEDP and any vasospasm produced by Beta blockers |
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what is the benefit of adding CALCIUM CHANNEL BLOCKER PLUS BETA BLOCKER
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Beta blocker blocks reflexogenic increase in HR and contractility
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what is the benefit of adding NITRATE PLUS CA CHANNEL BLOCKER
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decreased preload (NO) and afterload (CCB)
useful in vasospastic angina where beta blcoker not wanted |
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what is the benefit of adding Beta blocker + CCB + NO
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CCB decreases afterload
NO decreases preload BB decreases reflexogenic incr in HR and contractility that CCB and NO may cause |
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what drug is used for unstable refractory angina
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Neupgen
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what drug is indicated for chronic angina if normal treatment doesn't fix it
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ranolazine
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what does neupogen do
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boost white cells
CD34 stem cell injections promote angiogenesis |
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what is the rank of SE of vasodilation due to CCB
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aggrevation of ischemia due to reflex tachycardia increasing O2 demand
N>V=D |
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what is the rank of SE of myocardial depression
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negative inotropy which may worsen CHF b/c of a decrease in contractility
V=D>N |
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what are the SE of CCB
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relaxation of smooth muscle = constipation
vasodilation = reflex tachycardia increasing O2 demand myocardial depression = negative inotropy may worsen CHF b/c decrease in contractility nodal effects = heart block can be exacerbated |
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what drug inhibits If
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ivabradine hydrochloride
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what if If involved in
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modulation of NT induced changes in cardiac pacemaker activity
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