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31 Cards in this Set

  • Front
  • Back
what is diphenylalkylamine
verapamil
what are the propertiets of verapamil
has anti arr effects
arteriolar vasodilator
coronary vasodilator
negative inotropic effects
what drugs will decrease automaticity in SA node
verapamil/dilitizem
what drugs are arteriolar vasodilators
nifidepine
verapamil
diltiazem
what is the MOA of arteriolar vasodilation of verapamil/dilitiazem
decrease Ca entry into vascular smooth muscle leading to decrease in PVR, BP, afterload, and O2 demand
when would a coronary vasodilator be used
if vasospasm is cause of angina
what is the negative inotropic effect of Ca channel blockers
decrease Ca entry into cardiac muscles leading to decreased in contractility and O2 demand
what effect do verapamil and dilitizem have on venous return
none
what is the main effect of both verapamil and dilitiazem
decrease O2 demand by:
decrease afterload
decrease cardiac contractilty
in what case would dilitiazem decrease O2 demand and increase it supply as well
it will increase O2 supply if angina is due to vasospasm
what is an example of a dihydropyridine
nifedipine
what are the properties of nifedipine
PDE inhibitor
increases cAMP
MORE POTENT ARTERIOLAR VASODILATOR THAN VERAPAMIL AND DILITIAZEM
why is DHP not a good choice for angina
may cause reflex tachycardia which would increase O2 demand
what is the mechanism of action in angina of beta blockers
decrease HR and contractility therefore less O2 demand
what class of drug has shown to decrease mortality
Beta blockers
what is a negative effect of Beta blockers
increase LVEDP due to negative inotropic effects
what is a possible negative effect of negative inotropic effects
increase LVEDP
what are the properties of ranolzaine
inhibits late Na current
what is ranolazine indicated for
chronic angina if not adequately controlled by standard therapy
what is the benefit of adding NITRATE PULS BETA BLOCKER
beta blocker blocks reflexogenic increase in HR and contractility which nitrates produce
Nitrates attenuate increase in LVEDP and any vasospasm produced by Beta blockers
what is the benefit of adding CALCIUM CHANNEL BLOCKER PLUS BETA BLOCKER
Beta blocker blocks reflexogenic increase in HR and contractility
what is the benefit of adding NITRATE PLUS CA CHANNEL BLOCKER
decreased preload (NO) and afterload (CCB)
useful in vasospastic angina where beta blcoker not wanted
what is the benefit of adding Beta blocker + CCB + NO
CCB decreases afterload
NO decreases preload
BB decreases reflexogenic incr in HR and contractility that CCB and NO may cause
what drug is used for unstable refractory angina
Neupgen
what drug is indicated for chronic angina if normal treatment doesn't fix it
ranolazine
what does neupogen do
boost white cells
CD34 stem cell injections promote angiogenesis
what is the rank of SE of vasodilation due to CCB
aggrevation of ischemia due to reflex tachycardia increasing O2 demand
N>V=D
what is the rank of SE of myocardial depression
negative inotropy which may worsen CHF b/c of a decrease in contractility
V=D>N
what are the SE of CCB
relaxation of smooth muscle = constipation
vasodilation = reflex tachycardia increasing O2 demand
myocardial depression = negative inotropy may worsen CHF b/c decrease in contractility
nodal effects = heart block can be exacerbated
what drug inhibits If
ivabradine hydrochloride
what if If involved in
modulation of NT induced changes in cardiac pacemaker activity