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15 Cards in this Set
- Front
- Back
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what is on the surface of Influenza virus
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hemagglutinin
Neuraminidase |
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what allows the influenza virus to enter and exit the cell
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neuraminidase
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what is the primary attachment to sialic acid residues on the surface of the cell
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Hemagglutinin
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what occurs in an infleunza virus infection
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endocytosis
once inside endolysosome due to acidity it causes the ribonuclear part of the capside to come apart releasing its genome which goes directly to the nucleus virus needs acidification to break down the ribonuclear proteins |
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what is very important to the release of ribonuclear protein once acidification occurs
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M2 protein type A
NB protein type B |
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what is the MOA of Amantadine
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inhibits M2 protein
TYPE A ONLY |
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what is the MOA of Rimantadine
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inhibits M2 protein
TYPE A ONLY |
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what is the MOA of Zanamivir
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inhibits influenza neuraminidase
TYPE A AND B |
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what is the MOA of oseltamivir
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inhibits influenza neuraminidase
TYPE A AND B |
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what does inhibiting neuraminidase do to the infleunza virus
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prevents any new viruses from entering cell and any viruses in the process of being put together can't leave the cell
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tamiflu
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oseltamivir
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what is the ADME of Amantadine
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oral dosage form
excreted mostly unchanged |
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what is are the therapeutic utilities of M2 inhibitors
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prophylaxis for type A infection only
reduces severity and duration of disease |
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what are the properties of Oseltamivir
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prodrug
inhibits both type A and B renally excreted, probenacid increases blood levels oral dosage form |
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what are the properties of Zanamivir
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same MOA as oseltamivir
AEROSAL/DRY POWDER INHALER |
