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34 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Beta 1
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Heart
Kidneys |
Gs
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Beta 1
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Heart
Kidney |
Gs
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M1
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Enteric Nervous system & Nn
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Gq
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Nm
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Neuromuscular Junction
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Ion channel
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Nn
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ganglion of PNS, SNS and Adrenal Medulla
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Ion channel
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Beta 2
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Vasculature & Bronchial
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Gs - PKA - Increase Vasodilation, Decrease TPR
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Alpha 1
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Vasculature smooth muscle
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Gq
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Alpha 2
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Pre-synaptic neuron, vasculature
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Gi
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M2
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Heart
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Gi
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M3
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GI, Lungs, Bladder, Vasculature
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Gq - smooth muscle contraction
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Isoproterenol
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Non-selective direct adrenergic AGONIST
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Beta 1 & Beta 2 Systolic goes up, Diastolic goes down
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Epinephrine
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Non-selective direct adrenergic AGONIST
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Low doses - Beta 1 & 2 High doses - Beta 1 & 2 & Alpha1&2
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Norepinephrine
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Non-selective Alpha 1,2 & Beta 2 adrenergic AGONIST
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Increase TPR, HR & Contractility
Decrease blood flow to organs |
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Clonidine
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Selective Alpha 2 Adrenergic AGONIST
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Decrease - HR, MAP, NT release
- Vasodilation Exception - small blood vessels |
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Phenoxbenzamine
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Non-selective Alpha 1&2 Adrenergic ANTAGONIST
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Binds Irreversibly
Tachycardia, arrhythmia, NE release |
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Prazosin
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Selective Alpha 1 Adrenergic ANTAGONIST
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Decreases - contraction and ventricular filling pressure
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Metoprolol
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Selective (at small doses) Beta 1 Adrenergic ANTAGONIST
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Decreases HR, rate of relax, SA firing, Strength
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Dobutamine
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Selective Beta 1 Adrenergic AGONIST
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Heart - Increase HR, Force, Relax
Kidney - Increase Renin, AngII, ALD |
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Propranolol
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Non-selective Beta 2 Adrendergic ANTAGONIST
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Reduce HR, Contractility, BP
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Terbutaline
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Selective Beta 2 Adrenergic AGONIST
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CNS/SNS excitation, bronchial dilation, vasodilation
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Phenylephrine
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Selective Alpha 1 Adrenergic AGONIST
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Increased Afterload/Preload, VR, CO and vasoconstriction
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Cocain
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Indirect Adrenergic Agonist (CNS)
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Blocks the re-uptake of NE at the synapse
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Nitrous Oxide (NO)
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Endogenous compound made from M3 activation in endothelia of vasculature
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Causes Vasodilation in the smooth muscle of the vasculature
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Succinylcholine
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Depolarizing - Nicotinic & Muscarinic AGONIST
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Opens Ion channels at Ganglia, NMJ, and end organs - paralysis
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Neostigmine
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Indirect AGONIST Cholinesterase inhibitor
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Cannot cross BBB, Long duration of action, paralyzes due to increased Ach levels
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Organophosphates
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Irreversible Cholinesterase Inhibitor
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Lipophilic and treated with 2-PAM immediately
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Pilocarpine
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Non-selective Muscarinic AGONIST M1,2,3
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Crosses BBB, affects Heart & Endothelium SLUDE
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Acetylcholine
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Non-selective Muscarinic and Nicotinic AGONIST
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used to dilate the eyes
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Trimethaphan
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Nicotinic (Nn) Antagonist
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Ganglionic Blockade - for Aortic Dissection, decreases SNS, reduces BP & Reflex
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Atropine
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Non-selective Muscarinic ANTAGONIST
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Increases HR, Dilation, Hallucination, dry mouth, cannot pee (manages organophosphate exposures)
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Tubocurarine
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Direct Non-depolarizing Nicotinic (Nm) ANTAGONIST
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Doesn't allow Ach to do it's job, paralytic agent
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Isoproterenol
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Non-selective Beta 1,2 Adrenergic AGONIST
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Increased - Contraction, HR
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Oxymetazoline
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Non-selective Alpha 1,2 Adrenergic AGONIST
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Vasoconstriction, Increase HR, BP, Sympathetic
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Labetalol
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Beta 1 & Alpha 2 Antagonist
Beta 2 Partial Agonist |
lowers BP
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