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25 Cards in this Set

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PCN, MOA?
1) inhibits final stage (of 3 stage process) of cell wall synthesis
2) bacteriocidal
resistance mechanisms for PCN
1) beta-lactimases = plasmid-mediated or chromosomal
2) altered PCN binding proteins
3) porin mutation
4) failure to activate autolytic enzymes in cell wall
natural PCNs
1) Pen G (prototype)
2) Pen V
Pen G and V, DOC for?
1) gram pos. cocci
2) Bacteroides
3) Fusobacterium
4) Pasteurella multocida
Pen V
1) more acid stable
2) better absorbed orally
Procaine PCN
1) Duracillin
2) Wycillin
Benzathine PCN
1) Bicillin
Penicillinase-resistant PCNs
1) Methicillin (Staphcillin)
2) Nafcillin (Unipen)
3) Oxacillin (Prostaphlin)
4) Cloxacillin (Tegopen, Cloxapen)
5) Dicloxacillin (Dynapen)
these PCNs are active vs?
1) Staph. aureus
2) gram + cocci
Aminopenicillins
1) Ampicillin
2) Amoxicillin
Ampicillin is DOC for?
1) Listeria monocytogenes
2) E.coli
3) Proteus mirabilis
4) Eikenella corrodens
Extended spectrum (antipseudomonal ) PCNs
1) Carboxypenicillins
2) Ureidopenicillins
Carboxypenicillins
1) Carbenicillin (Geopen)
2) Ticarcillin (Ticar)
Ticarcillin (Ticar) + Aminoglycoside =
DOC for Pseudomonas aeruginosa
SE of Carboxypenicillins
high Na content can lead to CHF
Ureidopenicillins
1) Piperacillin (Pipracil)
2) Mezlocillin (Mezlin)
Amoxicillin + Clavulanic acid (beta-lactamase inhibitor)=
Augmentin (PO)
Ticarcillin + Clavulanic acid =
Timentin (IV)
PCN + beta-lactamase inhibitors covers?
class 2-6 beta-lactamase-producing bacteria
Ampicillin + Sulbactum =
Unasyn (IV)
Piperacillin + Tazobactam =
Zosyn (IV)
PCN do not freely enter?
CSF but pass through inflamed meninges more rapidly
adverse effects of PCN
1) hypersensitivity
2) Ampicillin rash
3) diarrhea
4) seizure
5) phlebitis or pain upon injection
6) Na load = CHF
7) Jarisch-Herxheimer reaction with secondary syphlis pts
hypersensitivity of PCN
cross sensitization with all PCNs and partial cross-sensitization with cephalosporins
prophylactic use of PCNs
1) rheumatic fever recurrence (Pen G or V)
2) to prevent endocarditis
(Amoxicillin, PO or Ampicillin, IV)