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26 Cards in this Set
- Front
- Back
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why are troches considered dry
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b/c very little water content
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what are the types of troches and which one does pits/coring occur
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gelatin
chocolate/peanut butter PEG -CORRING OCCURS |
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what is the max the drug can occupy in a troche
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30%
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what is an example of local Supp effect
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hemorrhoids
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what is an example of systemic Supp effects
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hormones/analgesics
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what are some of the routes of administration of Supp and which is only local
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urethral (ONLY LOCAL)
vaginal rectal |
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how long does the medication in Supp have to release
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6 hrs
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what are the types of Supp bases
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Olegeanous (fatty base)
Water miscible/soluble bases |
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what are examples of Olegeanous bases
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MBK base
Cocoa Butter |
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what are properties of Olegeanous bases
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lower MP than water soluble/miscible
MELT AT BODY TEMP TO RELEASE DRUG FOR RECTAL USE ONLY STORE AT CONTROLLED ROOM TEMP OR REFRIDGERATE |
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what is an example of a suspending agent and what does it do
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silica gel
insures the uniform distribution of the drug throughout the supp |
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what are examples of water miscible/soluble bases
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PEG
Glycerinated Gelatin |
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what are PEG supp for
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vaginal use
many drug incompatabilities DEHYDRATE TISSUE |
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what type of Supp base is more comfortable
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fatty base
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what type of Supp base causes defecating reflex
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PEG
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how is the drug in water miscible/soluble bases released
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they dissolve in mucossal fluids
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which one is less reactive fatty base of PEG
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fatty base
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what type of base is used for retal, urethral, vaginal
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rectal = fatty base
urethral/vaginal = PEG vaginal = glycerinated |
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is the choice of base critical for local effects
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no
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what is the max amount of drug that be incorporated in a supp
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30% of its blank weight
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addition of what can increase bioavailability of penicillin and cephalosporin
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sodium carpate
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how do you check the MP of the final supp
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by using a water bath at 37 degrees to simulate body temp
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what is the double casing technique
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fill all supp 1/4 to 1/2 then top off with base then remelt then repour back into molds resulting in EVEN DISTRIBUTION
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what kind of medication is reserved for an as needed basis and doesn't require precise dosing
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lollipop
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what do lollipops not contain
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antibiotics
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what is the priciple of opposite characteristics/rule of differences
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want drug to be opposite to base its in so you can have rapid release
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