Pbt Pharmacology Of The Autonomic Nervous System - What Drugs Do What

Front 1

Uses: GI or urinary bladder paralysis (postoperative, neurogenic bladder)?

cholinergic agonist used primarily to stimulate smooth muscle cells in the GI tract or urinary bladder

Back 1

BETHANECHOL

Front 2

Treatment of glaucoma

Cholinergic agonist used primarily to stimulate M3 receptors on smooth muscle cells in the iris causing miosis and on ciliary muscle increasing outflow of aqueous humor?

Back 2

PILOCARPINE

Front 3

The only depolarizing neuromuscular blocking drug used clinically in the U.S. to induce paralysis during surgery

It stimulates the nicotinic receptor, opening the channel and depolarizing the motor end-plate

This results in a brief period of excitation that manifests itself by widespread fasciculations in muscle cells

Because ____ is not metabolized effectively at the synapse, the depolarized membranes remain depolarized and unresponsive to subsequent impulses, resulting in a flaccid paralysis?

Back 3

Succinylcholine

Front 4

Treatment of myasthenia gravis

Indirect cholinomimetic: stimulates acetylcholine receptors by increasing the concentration of endogenous Ach at the synapse?

Back 4

Neostigmine

Front 5

used to treat CNS toxicity from atropine overdose?

Back 5

Physostigmine

Front 6

used as a short-acting (2-10 minutes) cholinesterase inhibitor?

Back 6

Edrophonium

Front 7

used to combat the inhibitory effects of Organophosphates on acetylcholinesterase which used as insecticides or nerve gases in chemical warfare?

Back 7

Pralidoxime

Front 8

Uses: Cardiovascular disorders (diseases with cardiac slowing), Respiratory disorders (asthma, preoperative treatment to prevent increased airway secretion induced by anesthetics), Urinary and GI disorders (spastic bowel disorder, inflammatory bowel disorders)

blocks muscarinic receptors preventing their activation by
agonists like acetylcholine?

Back 8

Atropine

Front 9

used to prevent motion sickness?

Back 9

Scopolamine

Front 10

used to treat peptic ulcers?

Back 10

Pirenzepine

Front 11

used in the treatment of chronic obstructive pulmonary disease?

Back 11

Ipratropium

Front 12

What class of drug?

Produces nondepolarizing (competitive) neuromuscular blockade during surgical procedures
Acts by preventing endogenous Ach from binding to nicotinic receptors and causing muscle cell depolarization without excitatory fasciculations.

Results in flaccid paralysis similar to myasthenia gravis

Back 12

Nicotinic NM Receptor Antagonist at Skeletal Neuromuscular End-plates

Front 13

Used to treat hypertension in patients with acute dissecting aortic aneurysms

Back 13

triimethophan or mecamylamine

Front 14

type of adrenergic drug used to treat: Mydriasis (retina examination)

Back 14

Alpha-1

Front 15

type of adrenergic drug used to treat: Glaucoma
(decrease aqueous humor secretion)

Back 15

Beta

Front 16

type of adrenergic drug used to treat: Hypotension (shock)
Heart Failure

Back 16

nonselective alpha

Front 17

type of adrenergic drug used to treat: Hypertension

Back 17

alpha

Front 18

type of adrenergic drug used to treat: Cardiac arrhythmias

Back 18

beta

Front 19

type of adrenergic drug used to treat: Suppression of premature labor

Back 19

beta-2 selective

Front 20

type of adrenergic drug used to treat: Bronchial asthma

Back 20

beta-2 selective

Front 21

used to treat shock

Back 21

Norepinephrine (NE)

Front 22

used to treat acute asthma and anaphylaxis

Back 22

Epinephrine (EPI)

Front 23

used to treat low cardiac output shock accompanied by compromised renal function leading to oliguria

Back 23

Dopamine (DA)

Front 24

Uses: Generally used to increase blood pressure in certain hypotensive conditions (shock). It is also an effective mydriatic and decongestant

Back 24

phenylephrine

Front 25

treatment of hypertension also used to treat symptoms associated with drug withdrawal

Back 25

clonidine

Front 26

drug of choice for treatment of hypertension during pregnancy

Back 26

methyldopa

Front 27

Uses
To relieve broncho-constriction (B2 effect)

To lower peripheral vascular resistance and diastolic BP (B2 effect)

To maintain or increase systolic BP (B1 effect)

To increase cardiac output by increasing cardiac contractility (positive inotropic effect) and increasing heart rate (positive chronotropic effect)

Back 27

Isoproterenol

Front 28

Uses: Heart failure, cardiogenic shock

Back 28

Dobutamine

Front 29

Used to treat obstructive airway disease and acute broncho spasm

Back 29

Metoproterenol

Front 30

Most widely used drug for the treatment of asthma

Back 30

Albuterol