Pb&t Pharma Of Hemostasis & Thrombosis

Front 1

Drug Class?
Inhibit cyclooxygenase thereby blocking thromboxane A2 generation and inhibiting platelet granule release rxn and platelet aggregation.

Back 1

Antiplatelet Agents
Cyclooxygenase inhibitors
(Aspirin)

Front 2

Drug Class?
Inhibit platelet cAMP degradation and thereby decrease platelet aggregability

Back 2

Antiplatelet Agents
Phosphodiesterase Inhibitor
(Dipyridamole)

Front 3

Drug Class?
Covalently modify platelet ADP receptor, thereby preventing receptor signaling and irreversibly inhibiting ADP dependent platelet activation pathway.

Back 3

Antiplatelet Agents
ADP Receptor Pathway Inhibitors
(Ticlopidine)
(Clopidogrel)

Front 4

Drug Class?
Bind to platelet receptor GPIIb-IIIa and thereby prevent binding of fibrinogen and other adhesive ligands.

Back 4

Antiplatelet Agents
GPIIb-IIIa Antagonists
(Eptifibatide)
(Abciximab)
(Tirofiban)

Front 5

Drug Class?
Inhibit hepatic epoxide reductase that catalyzes the regeneration of reduced vitamin K which is required for synthesis of biologically active coagulation factors II, VII, IX and X, and anticoagulant proteins C and S.

Back 5

Anticoagulants
Warfarin
(Warfarin)

Front 6

Drug Class?
Unfractionated heparin combines with antithrombin III and inhibits ssecondary hemostasis via nonselective inactivation of thrombin (factor IIa), factor Xa, factor IXa, Factor XIa and factor XIIa. LMW heparins: combine w/ antithrombin III and inhibits secondary hemostasis via relatively (3-fold) selective inactivation of factor Xa.

Back 6

Anticoagulants
Unfractionated Heparin and Low Molecular Wt Heparins
(Unfractionated Heparin)
(LMW Heparins: Enoxaparin, Dalteparin, Tinzaparin)

Front 7

Drug Class?
Combine w/ antithrombin III and inhibits secondary hemostasis via highly selective inactivation of facto Xa.

Back 7

Anticoagulants
Selective Factor Xa Inhibitors
(Fondaparinux)

Front 8

Drug Class?
Bind directly to thrombin and therby inhibit secondary hemostasis.

Back 8

Anticoagulants
Direct Thrombin Inhibitors
(Hirudin-related agents: Lepiruin, Desirudin, Bivalirudin)

Front 9

Drug Class?
Proteolytically inactivates factors Va and VIIIa; may also exert anti-inflam effects by inhibiting tumor necrosis factor production and blocking leukocyte adhesion to selectins.

Back 9

Anticoagulants
Recombinant Activated Protein C (r-APC)

Front 10

Drug Class?
Proteolytically activate plasminogen to form plasmin, which digests fibrin to fibrin degradation products.

Back 10

Thrombolytic Agents
(Streptokinase)
(Recombinant t-PA)
(Alteplase)
(Tenecteplase)
(Reteplase)

Front 11

Class of Drug?
Inactivates heparin by forming a stable 1:1 protamine: heparin complex.

Back 11

Inhibitors of Anticoagulation and Fibrinolysis
Protamine

Front 12

Class of Drug?
Inhibits serine proteases, including plamin, t-PA, and thrombin

Back 12

Inhibitors of Anticoagulation and Fibrinolysis
Aprotinin

Front 13

Class of Drug?
Analogues of lysine that bind to and inhibit plasminogen and plasmin.

Back 13

Inhibitors of Anticoagulation and Fibrinolysis
Lysine Analogues
(Aminocaproic acid)
(Tranexamic acid)