Pbr Lung Defense 3

Front 1

Which factors contribute to neutrophil chemotaxis?

Back 1

LPS, IL 1,8, TNF alpha; C3, 5 degradation; leukotriene B4

Front 2

Which chemokine is the major cytokine in eosinophil chemotaxis and maturation?

Back 2

IL 5**

Front 3

After immune stimulus, what doe eosinphils degranulate to release?

Back 3

Eosinophil granular proteins (Major basic protein); arachidonic acid metabolites; reactive O2; intermediates, cytokines,peptide mediators (substance P, VIP)

Front 4

What kind of helper cells mediate allergic inflammatory reaction vs non allergic inflammation ?

Back 4

TH 1 – non –allergic; TH2 – allergic: (IL 4,5,6,9,10,13)

Front 5

Which IL does TH2 secresret that leads to allergic rxn?

Back 5

IL 4,5,6,9,10,13

Front 6

Which cells make toxic granules which induce: death of pathogen infected cells esp viruses/pneumonitis) and are the primary effector cells in graft rejection ?

Back 6

Cytotoxic T cells

Front 7

Which cells are part of adaptive immune response rsponseible for humaral immunity relating to antibodies?

Back 7

B cells

Front 8

Which IG is made by plasma B cells and is most abundant IG in circulation and alveoli?

Back 8

IgG

Front 9

Which Ig is major Ig found in mucous secetions and upper airway?

Back 9

sIgA

Front 10

Which Ig deficiency is ~ atopy and airway reactivity?

Back 10

IgA

Front 11

? cells are part of innate immune system and play a major role in defending host from both tumors and virally infected cells

Back 11

NK cells

Front 12

What is pulmonary lung lymph made of ?

Back 12

Lymphocytes, protein, lipids

Front 13

What factors are responsible for abpsortion for lung lymph fluid balance?

Back 13

10% of interstitial fliud enters lymphatic capillaries to become lymph before returning back to blood

Front 14

What factors are responsible for secretion (chylothrorax) for lung lymph fluid balance?

Back 14

Trauma of duct; thrombus of left or right subclavian vein; malformations; malignancy in upper thorax

Front 15

What are immunosuppressive drugs in lung transplant?

Back 15

Steroids, caineruin inhibitors, antiproliferatives; mTOR inhibitors

Front 16

Which diz results from defect in phagocytosis , decreased reactive O2 species made by NADPH oxidase complex

Back 16

CGD: chronic granulomatous diz

Front 17

How dx CGD?

Back 17

Negative netrohpil oxidative burst test

Front 18

Di-George, wiskot-aldrich, Ataxia-telangiectasia; ~ infx include PCP, nocardia, andida, legionella, virsues, parasites, mycobacteria are all associated w/ kind of cellular immunity?

Back 18

Impaired cellular immunity

Front 19

X-linked hypogammaglobulinemia, CVID, IgG deficiency or Ig G subclass 2 or 3 deficiency ~ infx include encapsulated organz: s. pnuemo.; h. influ; neissearia or s. aureus) is what kind of immunity?

Back 19

Humoral

Front 20

Major basic protein is made by which cell? Eoinsohpils, Epithelial cells, Lymphocytes, Neturophils

Back 20

Eosionphils

Front 21

Which inflammatory protine causes vasodilation? Bradykinin, Interleukin-2, Thromboxane, Endothelin

Back 21

Interleukin 2

Front 22

Which mediator reduces the inflammatory response? IL -10, TGF alpha, TNF –alpha, Vasoactive intestinal protein,

Back 22

IL 10

Front 23

Which hcytokine mediates eosinophil chemotaxis and maturation? IL 1,2,5,6

Back 23

IL -5

Front 24

Mycophenolic acid produces immune modulation through which mechanism? Prevents natural killer cell-mediated activation by inhibiting phosphadytilinositol 3 kinase, Inhibits calcinuerin mediated transcription of IL2, Purine analogue which inhibits synthesis of DNA in proliferating lymphocytes, Binds to mammalian target of rapamycin, leading to inhibitionof T cell proliferation,

Back 24

Purine analogue which inhibits synthesis of DNA I nproliferating lymphoctyes

Front 25

What surfactant proteins are ceollecings modulating the innate immune system by binding to microorganisms and facilitating phagocytois? (within in the epithelial cells)

Back 25

A and D

Front 26

The epithelial cells secrete anti-bacterial proteins called what ? 2 of them

Back 26

Beta defensins and lysozyme

Front 27

Which enzyme secreted by epithelial cells hydrolyzes structural components of bacterial cell wall?

Back 27

Lysozyme

Front 28

Why is the endothelium more permeable during an acute inflammatory process?

Back 28

b/c epithelium has tight junctions so it’s less permeable.

Front 29

Which drug (transplant) prevents actitation of NK cells? Prevents IL-2 transcription?

Back 29

calcinuerin inhibitor: Tacrolimus/cyclosprin: (when APC interacts w/ T cells, calcieurin is activated and increases transcription of IL2 and other cytokines which activate NK cells)

Front 30

Which drug (lung transplant) inhibits DNA synthesis, and affects proliferating cells, such as T and B cells)

Back 30

Purine analogue (azathioprine, mycophenolic acid/cellcept)

Front 31

Which drug disrupts IL2 Receptor signaling and inhibits T cell proliferation?

Back 31

mTOR inhibitors (rapamycin, siroliums everolimus)