Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
What is extraceleeular matrix composed of?
|
Of fibrous structural proteins and interstitial matrix, the latter being composed of adhesive glycoproteins embedded within a ground substance.
|
|
|
What are some structural proteins of ECM?
|
Collagen fibers, reticular fibers and elastic fibers.
|
|
|
What is collagen?
|
It is a triple helix of 3 polypeptide alpha chains that is secreted by fibroblasts and has a high content of glycine and hydroxyproline.
|
|
|
Collagens can be fibrillar and non-fibrillar. TRUE/FALSE
|
TRUE. The fibrillar(interstitial tissue) types of collagen(types 1, 3 and 5 are found within the ECM(interstitial tissue), while the non fibrillar type 4 collagen is found within the basement membranes, which are special organizations of the interstitial matrix found around epithelial, endothelial and smooth muscle cells.
|
|
|
Where is type 1 collagen found?
|
It is found in skin, tendon, bone, dentin and fascia.
|
|
|
Where is type 2 collagen found?
|
It is found only in cartilage.
|
|
|
Where is type 3 collagen found?
|
Type 3 (reticulin) appears in the skin, blood vessels, uterus and embryonic dermis.
|
|
|
What are the adhesive proteins?
|
These include fibronectin and laminin.
|
|
|
What is laminin?
|
This is the most abundant glycoprotein that is capable of binding multiple matrix components, such as type 4 collagen and heparan sulfate. It also binds to specific receptors on the surface of some cells.
|
|
|
What is fibronectin?
|
It is secreted by fibroblasts, monocytes, and endothelial cells. It is also capable of binding many substances, such as collagen, fibrin, proteoglycans and integrins.
|
|
|
What does fibronectin link?
|
It links the ECM component and macromolecules to integrins and is chemotactic for fibroblasts and endothellial cells.
|
|
|
Is fibronectin cross shaped like laminin?
|
No. It is a large glycoprotein composed of 2 chains held together by disulfide bonds.
|
|
|
Where is albumin secreted from?
|
It is secreted by hepatocytes and is mainly responsible for intravascular oncotic pressure, while immunoglobulins are secreted by plasma cells and are important in mediating humoral immunity.
|
