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20 Cards in this Set
- Front
- Back
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Erythrocyte membrane proteins target antigen for?
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Autoimmune hemolytic anemia (Type II)
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opsonization and phagocytosis. mechanism for which diseases?
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Autoimmune Hemolytic Anemia (of rbcs)
Autoimmune Thrombocytopenic Purpura (of platelets). (Type II) |
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Platelet membrane proteins gpIIb: IIIa and integrin. target antigens for?
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Autoimmune thrombocytopenic Purpura
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Pemphigus vulgaris. hypersensitivity type?
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Type 2
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Proteins in intercellular junctions of epidermal cells (epidermal cadherin). antigen for?
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Pemphigus vulgaris (type 2)
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Antibody mediated activation of proteases. disruption of intercellular adhesions. mechanism for?
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pemphigus vulgaris (type 2)
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Vasculitis by ANCA. hypersensitivity type?
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Type 2
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PMN granule proteins. target antigen for?
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vasculitis caused by ANCA (type 2)
ANCA = anti-neutrophil cytoplasmic antibody. duh. |
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PMN degranulation and inflamm. mechanism of disease for?
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vasculitis by ANCA (type 2)
ANCA = anti-neutrophil cytoplasmic antibody. duh. |
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Noncollagenous protein in BM. target antigen for what disease?
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Goodpasture Syndrome (type 2)
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Complement and Fc receptor mediated inflamm. mechanism for what disease?
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Goodpasture Syndrome (type 2)
(noncallagenous protein in BM of kidney glomeruli and lung alveoli = target antigen) |
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Acute Rheumatic Fever. Hypersensitivity type?
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Type 2. Streptococcal cell wall antigen is actual target antigen. but antibody made to it cross-reacts with myocardial antigen.
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Inflamm and macrophage activation. mech of disease for?
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Acute Rheumatic Fever. (type 2)
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Myasthenia Gravis. hypersensitivity type?
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type 2
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ACh receptor target antigen for? mechanism of disease?
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Myasthenia Gravis (type 2). inhibits ACh binding, down modulating receptors.
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Graves disease - hypersensitivity type?
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Type 2
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TSH receptor. target antigen for? mechanism of disease?
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Graves disease. antibody stimulates TSH receptor (hyperthyroidism)
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Insulin Resistant diabetes. Hypersensitivity type?
mechanism of disease? |
Type 2.
Insulin receptor is target antigen. Antibody binding inhibits binding of insulin. HYPERGLYCEMIA AND KETOACIDOSIS result!!!! met acidosis (bring it back) |
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Pernicious anemia. hypersensitivity type?
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Type 2.
antigen = IF (from gastric parietal cells). Neutralizes IF, decreasing Vit B12 reab subsequently |
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Skin bullae/vesicles seen in which disease?
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Pemphigus vulgaris (type 2)
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