Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
increased production of this w/ IL-12 from macrophages
|
TH1
|
|
|
makes IL-2 and IFN gamma
|
TH1 (In HIV, dysfunction results in decreased production of these)
|
|
|
This type of lymphocyte important for delayed hypersensitivity, macrophage activation and antibody synthesis
|
TH1
|
|
|
helminthes
|
TH2 b/c its IL-5 activates eosinophils
|
|
|
these antibodies on surface of all naive b cells
|
IgM and IgD
|
|
|
has complement receptor, Fc receptor, and EBV receptor
|
B cells
|
|
|
has CD40
|
B cells (ligand on T cells)
|
|
|
phagocytosis and APC via complement or antibodies
|
macrophages
|
|
|
APC, under epithelium so primary immune response role. receptor for Fc and complement too. NOT cytotoxic
|
Dendritic cells
|
|
|
Cytotoxic. Antibody dep killin (via IgG Fc receptor) or antigen independent killing. kills tumor cells, virally infected cells like T lymphocytes, but not MHC class dependent
|
NK cells
|
|
|
self recognition of MHC 1 inhibits killing
|
NK cell
|
|
|
makes IFN gamma and TNF
|
NK cells
|
|
|
make proteolytic enzymes, oxygen metabolites, ARACHIDONIC ACID METABOLITES
IL-1, IL-6, IL-8 TNF CAMP |
macrophages
|
|
|
non antigen dependent phagocytosis, no killing. Granules w/ degradative enzymes, oxidative metabolites and HYPOPHALOUS ACID
also Fc receptor so can do antibody dependent phagocytosis |
PMN
|
|
|
Have Major Basic Protein
Lipid mediators (leukotrienes) oxygen radicals cytokines |
eosinophils. important in helminths and asthma
|
|
|
late phase allergic response
|
basophils
|
|
|
histamine, leukotrienes, PGs, PAF. IgE receptor
|
basophils
|
|
|
important for intracelllular microbes
|
TH1
|
|
|
this IL activates eosinophils
|
IL-5
|
|
|
this IL promotes self proliferation of T cells
|
IL-2
|
