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13 Cards in this Set

  • Front
  • Back
what medication is associated with causing pulmonary hypertension
anorexignes (aminorex fumarate of fenluramine) used for weight loss
what is the normal function of bone morphogenic protein
normally necessary for apoptosis for precapillary pulmonary arterioles
*decreased results in pulmonary hypertension
an over-expression of what receptors trigger VSM hypertrophy and are associated with pulmonary HTN
serotonin receptors
down regulation of what receptors leads to pulmonary HTN
voltage-gated potassium channels
three genetic mutations associated with development pulmonary HTN
1. decreased BMPR2
2. over-expression of 5-HT receptors
3. down-regulation of potassium channel
how could idiopathic pulmonary HTN lead to decreased PaO2
increased (A-a)O2 gradient due to decreased number of patent pulmonary vessels
differentiate central and peripheral cyanosis
central - arterial oxygen desaturation or abnormal Hb
peripheral - slow transit of blood or excessive oxygen utilization
is cyanosis more likely to develop in severe polycythemia of anemia
polycythemia
differentiate what warm and cold recpetors activate
warm stimulate the anterior hypothalamus to increase cholinergic discharge
cold stimulate the posterior hypothalamus to increase sympathetic discharge
activation of which part of the hypothalamus leads to increased body temperature
posterior hypothalamus
what are some physiologic events that cause the body's temperature to rise
1. induce fever via PGE2
2. increased cutaneous vasoconstriction
3. nonshivering thermogenesis - uncouple oxidative phosphorylation
4. shivering thermogenesis
how does PGE2 induce fever
increases the release of cAMP which decreases the discharge rate of warm-sensitive neurons in the anterior hypothalamus
which medication can normalize the body's temperature even in the presence of systemic infection
glucocorticoids
*decreases synthesis pyrogens and indirectly decrease synthesis of PGE2 by inhibiting phosphlipase A2