Pathology_3 10: Cirrhosis

Front 1

3 morphological changes in cirrhosis

Back 1

bridging fibrosis
loss of architecture
regenerative nodules

Front 2

micronodules are <___ in diameter

Back 2

3mm

Front 3

3 main causes of death from cirrhosis

Back 3

hepatic coma
hematemesis from esophageal varices
HCC

Front 4

3 kinds of alcoholic liver disease (ALD)

Back 4

fatty liver
alcoholic hep
alcoholic cirrhosis

Front 5

fatty liver is grossly ___
fatty liver typically weighes ___ kg

Back 5

large
soft
yellow
4--6

Front 6

alcoholic hep is caused by ___. ___ may be seen inside ___.

Back 6

bout of heavy drinking
mallory bodies
damaged hepatocytes

Front 7

T/F: alcoholic hep is always reversible

Back 7

false

Front 8

early in alcoholic cirrhosis liver is grossly ___ (3). later it is ___ (3).

Back 8

large
yellow
fatty
shrunken
brown
non-fatty

Front 9

men/women are more susceptible to alcoholic damage

Back 9

women

Front 10

postnecrotic cirrhosis is ___nodular

Back 10

macro

Front 11

4 causes of postnecrotic cirrhosis

Back 11

HBV/HCV
hepatotoxins/drugs
massive liver necrosis
end stage alcoholic cirrhosis

Front 12

most common cause of postnecrotic cirrhosis

Back 12

chronic viral hep

Front 13

3 kinds of biliary cirrhosis

Back 13

1' (PBC)
2'
1' sclerosing cholangitis (PSC)

Front 14

___ hepatocyte degeneration is present in all biliary cirrhosis

Back 14

feathery

Front 15

PBC is caused by

Back 15

autoimmune attack on intrahepatic bile ducts

Front 16

PBC is more common in men/women

Back 16

women (6:1)

Front 17

auto Ab in PBC

Back 17

antimitochondrial (AMA)

Front 18

3 histopath findings in PBC

Back 18

granulomas
periportal hep with mallory bodies
fibrosis -> cirrhosis

Front 19

SBC is caused by ___. this may happen in ___ or ___.

Back 19

chronic obstruction of biliary tree
CF
tumor

Front 20

___ is a complication of SBC

Back 20

ascending cholangitis

Front 21

macroscopically PBC and SBC have ___ cirrhosis, with ___ (2) liver

Back 21

micronodular
hard
green

Front 22

4% of IBD have ___

Back 22

PSC

Front 23

___% of PSC patients have IBD

Back 23

70

Front 24

PSC is more common in men/women

Back 24

men

Front 25

histopath finding in PSC: ___ followed by ___.

Back 25

cholangitis
onion skin fibrosis of small and large bile ducts

Front 26

PSC is dxed by ___

Back 26

ERCP

Front 27

1' hemochromatosis is a ___ trait. more common in men/women

Back 27

AR
men

Front 28

2' hemochromatosis is caused by ___.

Back 28

hemolysis

Front 29

in 1' hemochromatosis Fe accumulates in ___ (6)

Back 29

liver
pancreas
heart
endocrine glands
joints
skin

Front 30

risk of ___ is dramatically increased in hemochromatosis

Back 30

HCC

Front 31

Wilson's disease damages ___ in brain

Back 31

basal ganglia

Front 32

T/F: liver transplant cures 1' hemochromatosis

Back 32

false

Front 33

T/F: liver transplant cures Wilson's disease

Back 33

true

Front 34

T/F: liver transplant cures A1AT deficiency

Back 34

true

Front 35

___ cells located in ___ produce ___ and cause ___

Back 35

Ito
space of Disse
collagen
fibrosis