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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What do lysosomes degrade?
-What can sometimes remain undigested in lysosomes? |
Proteins and Carbohydrates
-Lipids can remain undigested |
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A lysosome w/ undigested debris (lipid)
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Residual Body
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Lipofusion Pigment Granule
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Undigested material from intracellular lipid peroxidation
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Rhemotoid Arthritis
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Autoimmune Disease
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Myopathy
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Disease of the Muscle or Muscle tissue
-Can result for glycogen and phospholipid accumulation in lysosomes |
Myo= Muscle
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If a drug interrupts lysosome function, what is the consequence?
-Name a drug that can do this |
Aquired or Drug Induced (Iatrogenic) Lysosomal Disease
-chloroquine= anti-malarial agent that raises the pH of a lysosome (inactivates its enzymes) |
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Induced by a patient's physician for therapy against infection or complicated treatment
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Iatrogenic
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Barbiturates
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Used to depress the central nervous system
Used as sedatives or hypnotics |
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What is the funtion of the Smooth ER?
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metabolizes various chemicals and cells exposed to the chemicals
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What is the adaptive response of the Smooth ER when exposed to chemicals?
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Hypertrophy (Increased size of cells)
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Protracted
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Prolonged// Continued
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Extended (Protracted) use of Barbituates leads to a state of tolerance and decrease effect of the drug.
-Physician will increase dosage -Pts are said to have adapted to the drug Explain what happed? |
Hypertrophy of the Smooth ER of hepatocytes, which metabolize the drug
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Name a site of Mitochondrial Myopathies (increased mitochondria)
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-Skeletal Muscle
(Metabolic Disease) |
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Certain benign tumors found in the kidney, PT, Thyroid, and Salivary Gland contain cells called ____.
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Oncocytes w/ abundantly large mitochondria
-cell has a Eosinophilic Apperance |
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T or F. Hypertrohy of the Liver can result from alterations in the mitochondria (large//small)
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T
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What is the result of defects in the cytoskeleton
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Defects in cell function
-cell movement -Intracellular organelle movement -Intracellular accumulation of fibrillar material |
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Thin filaments have actin and myosin and assoc. proteins. Some drugs target these components. Name them
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-Cytochalasin B prevents polymerization of actin filaments
-Phalloidin toxin of mushroom (amanatin phalloides)also binds actin filaments |
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Defect in microtubles can result in what cells being effected
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Sperm cells>> male sterility
Immobilize cilia in respiratory tract |
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